Retraction Notice to: RhoE Is a Pro-Survival p53 Target Gene that Inhibits ROCK I-Mediated Apoptosis in Response to Genotoxic Stress (original) (raw)

. Author manuscript; available in PMC: 2019 Jul 22.

Published in final edited form as: Curr Biol. 2019 Jun 17;29(12):2107. doi: 10.1016/j.cub.2019.05.065

Current Biology is retracting this paper, which reports that p53-mediated induction of RhoE in response to genotoxic stress promotes cell survival in part via inhibition of ROCK I-mediated apoptosis. Several years after publication of this work, two corrections to this paper were published in this journal in response to reader concerns regarding apparent duplication of western blots and irregularity of FACS plots in Figures 2 and 4 (https://doi.org/10.1016/j.cub.2012.11.007; https://doi.org/10.1016/j.cub.2016.07.072). A review conducted by Harvard Medical School and Massachusetts General Hospital has now identified further issues involving data within Figure 2. In light of the cumulative issues, we have concluded that the most responsible course of action is therefore to retract the paper. The corresponding author, Sam W. Lee, does not agree with _Current Biology_’s decision to retract the paper.