Emerging and reemerging helminthiases and the public health of China (original) (raw)

Abstract

Despite great strides in their control throughout the People's Republic of China, helminth infections remain an important public health problem. The Institute of Parasitic Diseases of the Chinese Academy of Preventive Medicine, under the guidance of the Chinese Ministry of Health, completed a nationwide survey of more than 1 million people that showed the high prevalence and intensity of intestinal nematode infections; prevalence can sometimes exceed 50% in the Yangtze River valley provinces. Schistosoma japonicum is also a major cause of illness in this region. Attempts to control Chinese helminthic diseases with conventional anthelminthic drugs have been partially thwarted by high posttreatment rates of reinfection. Recently, several new human trematode pathogens have been identified. Novel approaches to chemoprophylaxis and vaccination may alleviate the public health problem caused by Chinese helminths. However, recombinant helminth vaccine development will depend on first cataloguing the extensive genetic diversity of Chinese helminths and candidate vaccine antigens. Evidence from biogeography, genetics, and systematics suggests that the genetic diversification of Chinese helminths and their vectors is an ongoing evolutionary process that began 12 million years ago near the convergence of major Asian river systems. Construction of the Three Gorges Super Dam on the Yangtze River may promote the emergence and reemergence of new helminths and their snail vectors

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Selected References

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  1. Albonico M., Smith P. G., Ercole E., Hall A., Chwaya H. M., Alawi K. S., Savioli L. Rate of reinfection with intestinal nematodes after treatment of children with mebendazole or albendazole in a highly endemic area. Trans R Soc Trop Med Hyg. 1995 Sep-Oct;89(5):538–541. doi: 10.1016/0035-9203(95)90101-9. [DOI] [PubMed] [Google Scholar]
  2. Chen M. Control and research on schistosomiasis in China. Chin Med J (Engl) 1995 Sep;108(9):643–646. [PubMed] [Google Scholar]
  3. Davis G. M., Chen C. E., Kang Z. B., Liu Y. Y. Snail hosts of Paragonimus in Asia and the Americas. Biomed Environ Sci. 1994 Dec;7(4):369–382. [PubMed] [Google Scholar]
  4. Davis G. M. Evolution of prosobranch snails transmitting Asian Schistosoma; coevolution with Schistosoma: a review. Prog Clin Parasitol. 1993;3:145–204. doi: 10.1007/978-1-4612-2732-8_6. [DOI] [PubMed] [Google Scholar]
  5. Davis G. M., Kitikoon V., Temcharoen P. Monograph on "Lithoglyphopsis" aperta, the snail host of Mekong River schistosomiasis. Malacologia. 1976;15(2):241–287. [PubMed] [Google Scholar]
  6. Ghosh K., Hawdon J., Hotez P. Vaccination with alum-precipitated recombinant Ancylostoma-secreted protein 1 protects mice against challenge infections with infective hookworm (Ancylostoma caninum) larvae. J Infect Dis. 1996 Dec;174(6):1380–1383. doi: 10.1093/infdis/174.6.1380. [DOI] [PubMed] [Google Scholar]
  7. He Y. X., Hu Y. Q., Yu Q. F., Tang Z. J. Characteristics of different isolates of Schistosoma japonicum from China in the final hosts. Southeast Asian J Trop Med Public Health. 1991 Jun;22(2):240–244. [PubMed] [Google Scholar]
  8. Hotez P. J., Hawdon J. M., Cappello M., Jones B. F., Ghosh K., Volvovitz F., Xiao S. H. Molecular approaches to vaccinating against hookworm disease. Pediatr Res. 1996 Oct;40(4):515–521. doi: 10.1203/00006450-199610000-00001. [DOI] [PubMed] [Google Scholar]
  9. Hsiao W. C., Liu Y. Economic reform and health--lessons from China. N Engl J Med. 1996 Aug 8;335(6):430–432. doi: 10.1056/NEJM199608083350611. [DOI] [PubMed] [Google Scholar]
  10. Liu S., Song G., Xu Y., Yang W., McManus D. P. Immunization of mice with recombinant Sjc26GST induces a pronounced anti-fecundity effect after experimental infection with Chinese Schistosoma japonicum. Vaccine. 1995 Apr;13(6):603–607. doi: 10.1016/0264-410x(94)00045-o. [DOI] [PubMed] [Google Scholar]
  11. Xiao S. H., You J. Q., Yang Y. Q., Wang C. Z. Experimental studies on early treatment of schistosomal infection with artemether. Southeast Asian J Trop Med Public Health. 1995 Jun;26(2):306–318. [PubMed] [Google Scholar]
  12. Xiao S., Shi Z., Zhuo S., Wang C., Zhang Z., Chu B., Zhen J., Chen M. Field studies on the preventive effect of oral artemether against schistosomal infection. Chin Med J (Engl) 1996 Apr;109(4):272–275. [PubMed] [Google Scholar]
  13. Xu L. Q., Yu S. H., Jiang Z. X., Yang J. L., Lai L. Q., Zhang X. J., Zheng C. Q. Soil-transmitted helminthiases: nationwide survey in China. Bull World Health Organ. 1995;73(4):507–513. [PMC free article] [PubMed] [Google Scholar]
  14. Xu L., Jiang Z., Yu S., Xu S., Chang J., Wu Z., Xu J., Zhang X., Chen Z., Zhang B. [Characteristics and recent trends in endemicity of human parasitic diseases in China]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 1995;13(3):214–217. [PubMed] [Google Scholar]
  15. Xu L., Jiang Z., Yu S., Xu S., Chen S., Lin J., Xu F., Li B., Lei C., Wang J. [Status and strategy of parasitosis control in preventive health care in China]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 1995;13(4):264–268. [PubMed] [Google Scholar]
  16. Xu L., Jiang Z., Yu S., Xu S., Meng N., Gan Y., Wang W., Li Y., Yang J., Ma W. [Nationwide survey of the distribution of parasites in China--the characteristics and rules of geographic distribution of human helminth infection]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 1995;13(2):99–103. [PubMed] [Google Scholar]
  17. Xu Z. B. Studies on clinical manifestations, diagnosis and control of paragonimiasis in China. Southeast Asian J Trop Med Public Health. 1991 Dec;22 (Suppl):345–348. [PubMed] [Google Scholar]
  18. Yu S. H., Jiang Z. X., Xu L. Q. Infantile hookworm disease in China. A review. Acta Trop. 1995 Aug;59(4):265–270. doi: 10.1016/0001-706x(95)00089-w. [DOI] [PubMed] [Google Scholar]
  19. Yu S. H., Xu L. Q., Jiang Z. X., Xu S. H., Han J. J., Zhu Y. G., Chang J., Lin J. X., Xu F. N. Nationwide survey of human parasite in China. Southeast Asian J Trop Med Public Health. 1994 Mar;25(1):4–10. [PubMed] [Google Scholar]
  20. Yu S. Control of parasitic diseases in China. Current status and prospects. Chin Med J (Engl) 1996 Apr;109(4):259–265. [PubMed] [Google Scholar]
  21. Yu S., Xu L., Jiang Z., Xu S., Han J., Zhu Y., Chang J., Lin J., Xu F. [Report on the first nationwide survey of the distribution of human parasites in China. 1. Regional distribution of parasite species]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 1994;12(4):241–247. [PubMed] [Google Scholar]