Aleksandar Djordjevic | University of Novi Sad, Faculty of Sciences (original) (raw)

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Papers by Aleksandar Djordjevic

Scientific Reports, 2020

The impact of fullerene C60 water soluble daughter molecules - fullerols C60(OH)24 nanoparticles ... more The impact of fullerene C60 water soluble daughter molecules - fullerols C60(OH)24 nanoparticles (FNP) on emerging (non-aflatoxin biosynthetic pathway) toxins production in mycelia and yeast extract sucrose (YES) media of A. flavus was investigated under growth conditions of 29 °C in the dark for a 168 h period. The FNP solution (10, 100 and 1000 ng mL−1) contained predominantly nanoparticles of 8 nm diameter and with zeta potential mean value of −33 mV. Ten emerging metabolites were produced at concentrations reaching 1,745,035 ng 50 mL−1 YES medium. Seven of the metabolites were found in mycelia and media, while three were only in mycelia. Majority of the metabolites were detected in higher quantity in mycelia than in media, at a ratio of 99:1 (m/m). However, higher metabolite quantities were found in media following FNP application, while FNP caused a decrease of total metabolite quantities in mycelia. The concentrations of the metabolites in media increased in the presence of 10...

Nanomaterials, 2020

Being a member of the nanofamily, carbon nanomaterials exhibit specific properties that mostly ar... more Being a member of the nanofamily, carbon nanomaterials exhibit specific properties that mostly arise from their small size. They have proved to be very promising for application in the technical and biomedical field. A wide spectrum of use implies the inevitable presence of carbon nanomaterials in the environment, thus potentially endangering their whole nature. Although scientists worldwide have conducted research investigating the impact of these materials, it is evident that there are still significant gaps concerning the knowledge of their mechanisms, as well as the prolonged and chronic exposure and effects. This manuscript summarizes the most prominent representatives of carbon nanomaterial groups, giving a brief review of their general physico-chemical properties, the most common use, and toxicity profiles. Toxicity was presented through genotoxicity and the activation of the cell signaling pathways, both including in vitro and in vivo models, mechanisms, and the consequentia...

Phys. Chem. Chem. Phys., 2016

Fullerenol nanoparticles show intriguing behaviour concerning their self-assembling at different ... more Fullerenol nanoparticles show intriguing behaviour concerning their self-assembling at different temperatures and concentrations and as such are promising potential agents for nanodrug delivery.

Pharmacological Reports, 2010

Polyhydroxylated fullerenes, named fullerenols (C 60 (OH) n ; n = 12-26) are excellent antioxidan... more Polyhydroxylated fullerenes, named fullerenols (C 60 (OH) n ; n = 12-26) are excellent antioxidants. Harmful effects of ionizing radiation on living organism are mainly mediated by free radical species and fullerenols attract an attention as a potential radioprotectors. Our preliminary investigations on mice and rats subjected to radiation injury show that fullerenol C 60 (OH) 24 provides high survival rate of irradiated small rodents. Radioprotective effect was comparable to that of the standard radioprotector amifostine.

Journal of Nanoscience and Nanotechnology, 2013

Recent data established the prospective applications for fullerenol (C 60 (OH) 24 nanoparticle (F... more Recent data established the prospective applications for fullerenol (C 60 (OH) 24 nanoparticle (FNP) in many fields, such as antioxidants, neuroprotective agents, and potential anti-radiation drugs. Leukemia cell sensitization to apoptosis induced by ionizing radiation is achieved by upregulation of ROS production and/or downregulation of antioxidative enzymes. Therefore, our aim was to analyze the potential role of fullerenol nanoparticle in modulation of the leukemic cellular response to irradiation. We used the qRT-PCR to analyze the expression level of mRNA for 11 genes in irradiated and FNP pre-treated irradiated K562 cells, and compared the gene expression level with the overall cell survival. Our results of the improved cell survival in FNP-treated irradiated cells and significant overexpression of anti-apoptotic Bcl-2 and Bcl-xL and cytoprotective genes such as GSTA4, MnSOD, NOS, CAT and HO-1 genes, may indicate that FNP exerts cytoprotective function in K562 leukemic cells, rendering K562 cells more tolerant to radiotherapy.

Novel nanocomposite containing fullerenol nanoparticles (FNP) and porous silica nanoparticles (PS... more Novel nanocomposite containing fullerenol nanoparticles (FNP) and porous silica nanoparticles (PSNs) was constructed and characterized. The capability of FNP to serve as a pore-capping agent and for entrapping 9-aminoacridine (9-AA) inside the pores of the PSN material was also demonstrated. Nitrogen sorption measurements evidence the successful capping of the silica pores while thermogravimetric analysis of FNP loaded PSN indicates the existence of pore-loaded fullerenol molecules. Higher amount of the drug release was noted by exposing the material to weakly acidic conditions in comparison to physiological pH, which may find application in targeted treatment of weakly acidic tumor tissues.

This review describes the chemical synthesis of polar polyhydroxylated fullerene C 60 derivatives... more This review describes the chemical synthesis of polar polyhydroxylated fullerene C 60 derivatives, fullerenols C 60 (OH) í µí± , 2 ≤ í µí± ≤ 44, C 60 H í µí± § O í µí±¥ (OH) í µí±¦ , and polyanion fullerenols C 60 (OH) 15 (ONa) 9 , ranging from the very first synthetic methods up to some contemporary approaches to synthesis and separation. It also provides some basic information about physical characteristics of fullerenols. With the increasing number of hydroxyl groups, water solubility of fullerenols increases as well. Fullerenols both in water and biological media build nanoparticles of different dimensions and stability. In different chemical and biological model systems a large number of various polyhydroxylated fullerene derivatives were tested and they showed both their antioxidative and prooxidative characteristics. Several mechanisms have been proposed for the antioxidant activity of fullerenol. In addition, this paper also provides insight into patents referring to the antioxidant properties of fullerenol.

A comprehensive comparative analysis of antifungal potential of benzalkonium chloride and newly s... more A comprehensive comparative analysis of antifungal potential of benzalkonium chloride and newly synthesized fullerenol/benzalkonium
chloride nanocomposite was conducted to assess the possible impact of carbon-based nanocarrier on antimicrobial
properties of the commonly used biocide. Physical characterization of synthesized nanocomposite showed zeta potential of
+37.4mV and inhomogeneous particles size distribution, with nanocomposite particles’ dimensions within 30–143nm and
maximum number of particles at 44 nm. The effect of pure and fullerenol nanocarrier-bound biocide was evaluated in eight
Aspergillus species. Inmycelial growth assay, nanocomposite was more potent, as fungicidal effect of 1.04/0.6 𝜇gmL−1 was obtained
in all but one of the isolates (A. niger), while proportional concentration of pure biocide (0.6 𝜇gmL−1) completely inhibitedmycelial
growth of only three Aspergillus species. However, conidia appear to be less susceptible to nanocomposite treatment, as lower
fungistatic (MIC) and fungicidal (MFC) concentrations were obtained with biocide alone (MIC in range from 0.03 to 0.15 𝜇gmL−1
and MFC from 0.075 to 0.45 𝜇gmL−1). To a different degree, both substances stimulated aflatoxin B1 production and inhibited
ochratoxin A synthesis. Very low mycelium biomass yield, in range from1.0 to 3.0mg dry weight, was documented in both biocide
and nanocomposite enriched medium.

Carbon nanomaterials have been the subject of extensive research over the past decade because of ... more Carbon nanomaterials have been the subject of extensive research over the past decade because of their use in many commercial products as well as their vast application in agriculture, medicine, electronic industry, cosmetics and others [1]. The molecules of fulleren C60 are by their nature hydrophobic and in water they tend to form nano aggregates (nC60). The high adsorptive capacity of nC60 can have an impact on transformation and transport of other hydrophobic organic compounds such as naphthalene, phenanthrene, pyrene, pesticides and others [2]. According to US National Toxicology Program’s twelfth report, chloroform is classified as carcinogen and is formed together with other disinfection by-products during water chlorination [3]. Suspended nano particles can either increase or decrease bioaccumulation of disinfection by-products [4]. Digestive tract of Daphnia magna is well known model system for toxicity evaluation of many diverse nano particles. Considering that nC60 can ch...

Books by Aleksandar Djordjevic

The unique size-dependent properties of carbon nanomaterials (CNMs)— graphene, nanotubes (CNTs) a... more The unique size-dependent properties of carbon nanomaterials (CNMs)— graphene, nanotubes (CNTs) and fullerenes— make them very attractive for diagnostic and therapeutic application. This chapter presents possible application of CNMs. Graphene with extraordinary chemical and physical properties has already revealed a great number of potential applications such as environmental toxic material removal, drug delivery, tissue engineering , and fl uorescence-based biomolecular sensing. The CNT derivatives have many interesting properties which make them potentially useful in a living system as biosensors, bioelectronic devices based on enzyme–nanotube or antibody–nanotube conjugates, chemotherapeutic agents, hyperthermia therapy and immunotherapy agents, agent in treatment of central nervous system disorders, and tissue engineering agent. Fullerene C 60 derivatives have been used as: drug and gene delivery vectors , magnetic resonance imaging agents, radio protectors, antioxidants, HIV-1 protease inhibitors, antigenotoxic agents, and phototherapy agents. Fullerenols are polyhydroxylated derivatives of fullerene (C 60 (OH)n) with remarkable antioxidant, xenobiotic-protective, radioprotective, nanodrug and endohedral gadolinium carrier properties.