Riccardo Sacco | Politecnico di Milano (original) (raw)

Uploads

Papers by Riccardo Sacco

Research paper thumbnail of Electro-fluid dynamics of aqueous humor production: simulations and new directions

Journal for modeling in ophthalmology, Dec 15, 2016

Research paper thumbnail of A Comprehensive Physically Based Approach to Modeling in Bioengineering and Life Sciences

A Comprehensive Physically Based Approach to Modeling in Bioengineering and Life Sciences, 2019

Research paper thumbnail of Multiscale modeling and simulation of neurovascular coupling in the retina

Modeling and Artificial Intelligence in Ophthalmology

The role of nitric oxide (NO), usually considered as a potent vasodilator, in regulating retinal ... more The role of nitric oxide (NO), usually considered as a potent vasodilator, in regulating retinal neurovascular coupling is still elusive. Measurements of flicker light-induced functional hyperemia (FH) in humans show that an increase of NO levels reduces vasodilation. This evidence has led to conjecture that such an increase may be responsible for suppressing flicker-evoked vasodilation in diabetic retinopathy. In this paper, we propose a mathematical model to theoretically investigate the effect of an increase in neural NO (nNO) on the vasodilation of retinal arterioles. Simulation results indicate that nNO increase may:1. significantly aff ect vasoconstrictive agent production by glial cells; and2. elicit vasoconstriction rather than vasodilation in retinal arterioles.Model predictions seem therefore to support the conjecture that NO increase may be responsible for suppressing flicker-evoked vasodilation in diabetic retinopathy.

Research paper thumbnail of A poroelastic model for the perfusion of the lamina cribrosa in the optic nerve head

Mathematical Biosciences, 2014

Research paper thumbnail of Nanoparticle-Based Retinal Prostheses: The Effect of Shape and Size on Neuronal Coupling

Photonics

The use of organic semiconductor nanoparticles (NPs) as retinal prostheses is attracting attentio... more The use of organic semiconductor nanoparticles (NPs) as retinal prostheses is attracting attention due to the possibility of injecting them directly into the desired tissue, with a minimally invasive surgical treatment. Polythiophene NPs localize in close proximity to the bipolar cell plasma membrane, which engulfs them, creating an intimate contact between the NP and the neuron. The intimate contact coupled with NP photoactivity are hypothesized to be the main guarantors of the electrostatic functioning of the bio-hybrid device. Since they may both be strongly affected by the geometric features of the NP, in this work, we use mathematical modeling to study the electrostatic polarization induced by light onto the NP and analyze how its spatial distribution is modified by varying the radius of the NP and its shape. Simulation results support the efficacy of the theoretical approach as a complementary virtual laboratory in the optimization of the current device and in the development ...

Research paper thumbnail of Exponentially fitted mixed finite volumes for energy balance models in semiconductor device simulation

Research paper thumbnail of A theoretical study of aqueous humor secretion based on a continuum model coupling electrochemical and fluid-dynamical transmembrane mechanisms

Communications in Applied Mathematics and Computational Science, 2019

Research paper thumbnail of A Stabilized Dual Mixed Hybrid Finite Element Method with Lagrange Multipliers for Three-Dimensional Elliptic Problems with Internal Interfaces

Journal of Scientific Computing, 2020

Research paper thumbnail of The role of structural viscoelasticity in deformable porous media with incompressible constituents: Applications in biomechanics

Mathematical Biosciences & Engineering, 2018

Research paper thumbnail of A poroelastic mixture model of mechanobiological processes in biomass growth: theory and application to tissue engineering

Research paper thumbnail of Analysis of Nonlinear Poro-Elastic and Poro-Visco-Elastic Models

Archive for Rational Mechanics and Analysis, 2016

Research paper thumbnail of A multiscale formulation of the Discontinuous Petrov–Galerkin method for advective–diffusive problems

Computer Methods in Applied Mechanics and Engineering, 2005

We consider the Discontinuous Petrov–Galerkin method for the advection–diffusion model problem, a... more We consider the Discontinuous Petrov–Galerkin method for the advection–diffusion model problem, and we investigate the application of the variational multiscale method to this formulation. We show the exact modeling of the fine scale modes at the element level for the linear case, and we discuss the approximate modeling both in the linear and in the non-linear cases. Furthermore, we highlight

Research paper thumbnail of Solution map analysis of a multiscale Drift–Diffusion model for organic solar cells

Computer Methods in Applied Mechanics and Engineering

Research paper thumbnail of Analytical and numerical study of photocurrent transients in organic polymer solar cells

Computer Methods in Applied Mechanics and Engineering, 2010

Research paper thumbnail of AN UPWIND-MIXED METHOD FOR ADVECTION-DIFFUSION PROBLEMS WITH STATIC CONDENSATION

Applied and Industrial Mathematics in Italy - Proceedings of the 7th Conference, 2005

Research paper thumbnail of On a viscous-hydrodynamic model for semiconductors: numerical simulation and stability analysis

Computing and Visualization in Science, 2001

. We deal with a hydrodynamic model for semiconductors with a physical viscosity in the momentu... more . We deal with a hydrodynamic model for semiconductors with a physical viscosity in the momentum/energy equations. The discretization uses a first-order finite difference scheme with upwinding based on the characteristic variables. We perform a stability analysis of the numerical method applied to a linearized incompletely parabolic system assuming vanishing viscosity in one space dimension although the analysis can be

Research paper thumbnail of Numerical Simulation of Resonant Tunneling Diodes with a Quantum-Drift-Diffusion Model

Mathematics in Industry, 2004

ABSTRACT The paper deals with the solution of the equations of a quantum-drift-diffusion (QDD) mo... more ABSTRACT The paper deals with the solution of the equations of a quantum-drift-diffusion (QDD) model for the description of transport in semiconductors. After providing these equations, one uses a linearization technique to get an approximation, and then one uses an iterative map and numerical algorithms to get the solution.

Research paper thumbnail of Multiscale simulation of organic heterojunction light harvesting devices

COMPEL - The international journal for computation and mathematics in electrical and electronic engineering, 2014

Research paper thumbnail of Multiscale Modeling of Heterojunction Organic Photovoltaic Devices

Mathematics in Industry, 2014

Research paper thumbnail of Stabilized mixed finite elements for fluid models in semiconductors

Computing and Visualization in Science, 1999

Research paper thumbnail of Electro-fluid dynamics of aqueous humor production: simulations and new directions

Journal for modeling in ophthalmology, Dec 15, 2016

Research paper thumbnail of A Comprehensive Physically Based Approach to Modeling in Bioengineering and Life Sciences

A Comprehensive Physically Based Approach to Modeling in Bioengineering and Life Sciences, 2019

Research paper thumbnail of Multiscale modeling and simulation of neurovascular coupling in the retina

Modeling and Artificial Intelligence in Ophthalmology

The role of nitric oxide (NO), usually considered as a potent vasodilator, in regulating retinal ... more The role of nitric oxide (NO), usually considered as a potent vasodilator, in regulating retinal neurovascular coupling is still elusive. Measurements of flicker light-induced functional hyperemia (FH) in humans show that an increase of NO levels reduces vasodilation. This evidence has led to conjecture that such an increase may be responsible for suppressing flicker-evoked vasodilation in diabetic retinopathy. In this paper, we propose a mathematical model to theoretically investigate the effect of an increase in neural NO (nNO) on the vasodilation of retinal arterioles. Simulation results indicate that nNO increase may:1. significantly aff ect vasoconstrictive agent production by glial cells; and2. elicit vasoconstriction rather than vasodilation in retinal arterioles.Model predictions seem therefore to support the conjecture that NO increase may be responsible for suppressing flicker-evoked vasodilation in diabetic retinopathy.

Research paper thumbnail of A poroelastic model for the perfusion of the lamina cribrosa in the optic nerve head

Mathematical Biosciences, 2014

Research paper thumbnail of Nanoparticle-Based Retinal Prostheses: The Effect of Shape and Size on Neuronal Coupling

Photonics

The use of organic semiconductor nanoparticles (NPs) as retinal prostheses is attracting attentio... more The use of organic semiconductor nanoparticles (NPs) as retinal prostheses is attracting attention due to the possibility of injecting them directly into the desired tissue, with a minimally invasive surgical treatment. Polythiophene NPs localize in close proximity to the bipolar cell plasma membrane, which engulfs them, creating an intimate contact between the NP and the neuron. The intimate contact coupled with NP photoactivity are hypothesized to be the main guarantors of the electrostatic functioning of the bio-hybrid device. Since they may both be strongly affected by the geometric features of the NP, in this work, we use mathematical modeling to study the electrostatic polarization induced by light onto the NP and analyze how its spatial distribution is modified by varying the radius of the NP and its shape. Simulation results support the efficacy of the theoretical approach as a complementary virtual laboratory in the optimization of the current device and in the development ...

Research paper thumbnail of Exponentially fitted mixed finite volumes for energy balance models in semiconductor device simulation

Research paper thumbnail of A theoretical study of aqueous humor secretion based on a continuum model coupling electrochemical and fluid-dynamical transmembrane mechanisms

Communications in Applied Mathematics and Computational Science, 2019

Research paper thumbnail of A Stabilized Dual Mixed Hybrid Finite Element Method with Lagrange Multipliers for Three-Dimensional Elliptic Problems with Internal Interfaces

Journal of Scientific Computing, 2020

Research paper thumbnail of The role of structural viscoelasticity in deformable porous media with incompressible constituents: Applications in biomechanics

Mathematical Biosciences & Engineering, 2018

Research paper thumbnail of A poroelastic mixture model of mechanobiological processes in biomass growth: theory and application to tissue engineering

Research paper thumbnail of Analysis of Nonlinear Poro-Elastic and Poro-Visco-Elastic Models

Archive for Rational Mechanics and Analysis, 2016

Research paper thumbnail of A multiscale formulation of the Discontinuous Petrov–Galerkin method for advective–diffusive problems

Computer Methods in Applied Mechanics and Engineering, 2005

We consider the Discontinuous Petrov–Galerkin method for the advection–diffusion model problem, a... more We consider the Discontinuous Petrov–Galerkin method for the advection–diffusion model problem, and we investigate the application of the variational multiscale method to this formulation. We show the exact modeling of the fine scale modes at the element level for the linear case, and we discuss the approximate modeling both in the linear and in the non-linear cases. Furthermore, we highlight

Research paper thumbnail of Solution map analysis of a multiscale Drift–Diffusion model for organic solar cells

Computer Methods in Applied Mechanics and Engineering

Research paper thumbnail of Analytical and numerical study of photocurrent transients in organic polymer solar cells

Computer Methods in Applied Mechanics and Engineering, 2010

Research paper thumbnail of AN UPWIND-MIXED METHOD FOR ADVECTION-DIFFUSION PROBLEMS WITH STATIC CONDENSATION

Applied and Industrial Mathematics in Italy - Proceedings of the 7th Conference, 2005

Research paper thumbnail of On a viscous-hydrodynamic model for semiconductors: numerical simulation and stability analysis

Computing and Visualization in Science, 2001

. We deal with a hydrodynamic model for semiconductors with a physical viscosity in the momentu... more . We deal with a hydrodynamic model for semiconductors with a physical viscosity in the momentum/energy equations. The discretization uses a first-order finite difference scheme with upwinding based on the characteristic variables. We perform a stability analysis of the numerical method applied to a linearized incompletely parabolic system assuming vanishing viscosity in one space dimension although the analysis can be

Research paper thumbnail of Numerical Simulation of Resonant Tunneling Diodes with a Quantum-Drift-Diffusion Model

Mathematics in Industry, 2004

ABSTRACT The paper deals with the solution of the equations of a quantum-drift-diffusion (QDD) mo... more ABSTRACT The paper deals with the solution of the equations of a quantum-drift-diffusion (QDD) model for the description of transport in semiconductors. After providing these equations, one uses a linearization technique to get an approximation, and then one uses an iterative map and numerical algorithms to get the solution.

Research paper thumbnail of Multiscale simulation of organic heterojunction light harvesting devices

COMPEL - The international journal for computation and mathematics in electrical and electronic engineering, 2014

Research paper thumbnail of Multiscale Modeling of Heterojunction Organic Photovoltaic Devices

Mathematics in Industry, 2014

Research paper thumbnail of Stabilized mixed finite elements for fluid models in semiconductors

Computing and Visualization in Science, 1999

Log In