Katarzyna Krukiewicz | Silesian University of Technology (original) (raw)

Uploads

Papers by Katarzyna Krukiewicz

The effect of oxygen conditioning on the performance of polyaniline (PANI) membranes is presented... more The effect of oxygen conditioning on the performance of polyaniline (PANI) membranes is presented and discussed. The presence of the conditioning effect in such kind of polymer matrix was confirmed by measuring a variation in spin concentration using EPR spectroscopy. The observed decrease in spin 10 concentration indicates the presence of the dissolved oxygen incompletely removed from PANI matrix. After the prolonged contact between oxygen and PANI membrane, a pronounced decrease in membrane’s selectivity was observed, which may be explained by the firm and permanent interaction between oxygen molecules and nitrogen paramagnetic centers of PANI and could be considered as a kind of PANI irreversible doping process.

Journal of Polymer Engineering, 2015

Materials Science and Engineering: C, 2016

Since the majority of anticancer pharmacological agents affect not only cancer tissue but also no... more Since the majority of anticancer pharmacological agents affect not only cancer tissue but also normal cells, chemotherapy is usually accompanied with severe side effects. Regional chemotherapy, as the alternative version of conventional treatment, leads to the enhancement of the therapeutic efficiency of anticancer drugs and, simultaneously, reduction of toxic effects to healthy tissues. This paper provides an insight into different approaches of local delivery of chemotherapeutics, such as the injection of anticancer agents directly into tumor tissue, the use of injectable in situ forming drug carriers or injectable platforms in a form of implants. The wide range of biomaterials used as reservoirs of anticancer drugs is described, i.e. poly(ethylene glycol) and its copolymers, polyurethanes, poly(lactic acid) and its copolymers, poly(ɛ-caprolactone), polyanhydrides, chitosan, cellulose, cyclodextrins, silk, conducting polymers, modified titanium surfaces, calcium phosphate based biomaterials, silicone and silica implants, as well as carbon nanotubes and graphene. To emphasize the applicability of regional chemotherapy in cancer treatment, the commercially available products approved by the relevant health agencies are presented.

Separation Science and Technology, 2016

The effect of oxygen conditioning on the performance of polyaniline (PANI) membranes is presented... more The effect of oxygen conditioning on the performance of polyaniline (PANI) membranes is presented and discussed. The presence of the conditioning effect in such kind of polymer matrix was confirmed by measuring a variation in spin concentration using EPR spectroscopy. The observed decrease in spin 10 concentration indicates the presence of the dissolved oxygen incompletely removed from PANI matrix. After the prolonged contact between oxygen and PANI membrane, a pronounced decrease in membrane’s selectivity was observed, which may be explained by the firm and permanent interaction between oxygen molecules and nitrogen paramagnetic centers of PANI and could be considered as a kind of PANI irreversible doping process.

Applied Surface Science, 2016

Bioelectrochemistry, 2016

As numerous therapeutic agents are not well tolerated when administrated systemically, localized ... more As numerous therapeutic agents are not well tolerated when administrated systemically, localized and controlled delivery can help to decrease their toxicity by applying an optimized drug concentration at extended exposure time. Among different types of drug delivery systems, conjugated polymers are considered as promising materials due to their biocompatibility, electrical conductivity and ability to undergo controllable redox reactions. In this work poly(3,4-ethylenedioxypyrrole), PEDOP, matrix is described for the first time as a reservoir of a model drug, ibuprofen (IBU). Drug immobilization process is performed in situ, during the electrochemical polymerization of 10 mM EDOP in the presence of 5-50 mM IBU. The loading efficiency of polymer matrix is dependent on IBU concentration and reaches 25.0±1.3 μg/cm2. The analysis of PEDOP-IBU chemical structure based on Raman spectroscopy, energy dispersive spectroscopy and surface morphology data provided by scanning electron microscopy shows that IBU is accumulated in the structure of matrix and evidently influences its morphology. IBU is then released in a controlled way under the influence of applied potential (-0.7 V vs. Ag/AgCl). It is demonstrated that the judicious choice of the synthesis conditions leads to a tailored loading efficiency of PEDOP matrix and to a tunable drug release.

Electrochemistry Communications, 2016

Związki zawierające ugrupowanie C-nitroazolowe są elementem struktury wielu leków o szerokim spek... more Związki zawierające ugrupowanie C-nitroazolowe są elementem struktury wielu leków o szerokim spektrum działania. Duża część z nich to związki o aktywności antypierwotniakowej i antybakteryjnej. Ta aktywność biologiczna wynika z zachodzącego w układach biologicznych procesu redukcji grupy nitrowej. Produkty pośrednie redukcji oddziałują na mikroorganizmy, powodując uszkodzenie ich DNA i zapobiegając ich dalszemu rozwojowi [1].

Chemioterapia jest jedną z najczęściej stosowanych metod leczenia chorób nowotworowych. Największ... more Chemioterapia jest jedną z najczęściej stosowanych metod leczenia chorób nowotworowych. Największą jej wadą są jednak skutki uboczne, tj. toksyczność względem zdrowych tkanek. Można tego uniknąć poprzez wykorzystanie miejscowych systemów dostarczania leków przeciwnowotworowych opartych na polimerach przewodzących. Związki te charakteryzują się zdolnościami jonowymiennymi, co jest szczególnie istotne przy immobilizacji i uwalnianiu związków o budowie jonowej. Triterpenoidy, to związki pochodzenia roślinnego o udowodnionym działaniu przeciwnowotworowym. Należący do tej grupy związków kwas oleanolowy wykazuje aktywność przeciwnowotworową w stosunku do linii komórkowych HeLa [5], L1210, K562 i HL-60, w różnych stadiach rozwoju nowotworu. W niniejszej pracy przedstawiono wyniki badań nad przewodzącymi matrycami polimerowymi zbudowanymi z poli(3,4-etylenodioksytiofenu), w których unieruchomione zostały cząsteczki kwasu oleanolowego. Immobilizacja przeprowadzona została z wykorzystaniem wo...

Following the interdisciplinary of the investigated phenomenon of self-heating it is necessary to... more Following the interdisciplinary of the investigated phenomenon of self-heating it is necessary to analyze the processes of structural modifications occurring in composites subjected to cyclic loading both from mechanical and chemical point of view for better understanding its degradation mechanisms. The paper presents experimental research results and analysis of structural degradation of polymer composites during occurrence of self-heating effect and thermal fatigue. Some characteristic aspects of the process were analyzed and discussed, i.e. structural changes in the polymer during occurrence of the selfheating effect, its connection with dynamic mechanical properties and thermokinetic laws and behaviour of the polymer when the glasstransition temperature is reached. Particularly, the process of residual cross-linking occurred during self-heating was analyzed; the results of experimental test were presented and interpreted following the chemical reactions, which occurred and have ...

One of the greatest challenges in neuroprosthetics is the specific design of the surface of neura... more One of the greatest challenges in neuroprosthetics is the specific design of the surface of neural implant [1]. Apart from exhibiting desired electrical properties and electrochemical stability, it should also be biocompatible. Numerous studies have shown that some conjugated polymers, mainly polypyrrole and poly(3,4-ethylenedioxythiophene), do not cause adverse effects, such as inflammation or immunological reaction, when introduced into tissues [2]. Because of the fact that conjugated polymers exhibit ion-exchangeable properties, it is possible to immobilize biologically active compounds of ionic nature in a conducting polymer matrix [3]. The ability to release biomolecules in a controlled manner realizes the concept of smart drug delivery systems [4]. The aim of this work was to design biologically active and conducting coating that may be utilized in neuroprosthetics. Poly(3,4-ethylenedioxythiophene), PEDOT, was chosen as a matrix, while sodium iso-butyl-propanoic-phenolate, IBU...

The discovery of intrinsically conducting polymers in 1977 by Shirakawa was a breakthrough in ele... more The discovery of intrinsically conducting polymers in 1977 by Shirakawa was a breakthrough in electrochemistry. Nowadays, conjugated polymers are widely known for their electrical properties and have found numerous applications in areas such as: organic solar cells, organic light-emitting diodes, supercapacitors, actuators, etc. Beside a great success of conducting polymers in electronics, they have been considered as materials for biomedical engineering. For the latest decade, numerous issues were proposed on this field like biosensors, artificial muscles, coatings for neuroprosthetics, drug delivery systems – all of them based on conducting polymers. It turned out that the choice of these materials was an unquestionable success. Selected conducting polymers, among them polypyrrole and poly(3,4-ethylenedioxythiophene), were proven as biocompatible and therefore neutral when introduced into a human body. The ability of these structures to conduct electricity is their additional adva...

The effect of oxygen conditioning on the performance of polyaniline (PANI) membranes is presented... more The effect of oxygen conditioning on the performance of polyaniline (PANI) membranes is presented and discussed. The presence of the conditioning effect in such kind of polymer matrix was confirmed by measuring a variation in spin concentration using EPR spectroscopy. The observed decrease in spin 10 concentration indicates the presence of the dissolved oxygen incompletely removed from PANI matrix. After the prolonged contact between oxygen and PANI membrane, a pronounced decrease in membrane’s selectivity was observed, which may be explained by the firm and permanent interaction between oxygen molecules and nitrogen paramagnetic centers of PANI and could be considered as a kind of PANI irreversible doping process.

Journal of Polymer Engineering, 2015

Materials Science and Engineering: C, 2016

Since the majority of anticancer pharmacological agents affect not only cancer tissue but also no... more Since the majority of anticancer pharmacological agents affect not only cancer tissue but also normal cells, chemotherapy is usually accompanied with severe side effects. Regional chemotherapy, as the alternative version of conventional treatment, leads to the enhancement of the therapeutic efficiency of anticancer drugs and, simultaneously, reduction of toxic effects to healthy tissues. This paper provides an insight into different approaches of local delivery of chemotherapeutics, such as the injection of anticancer agents directly into tumor tissue, the use of injectable in situ forming drug carriers or injectable platforms in a form of implants. The wide range of biomaterials used as reservoirs of anticancer drugs is described, i.e. poly(ethylene glycol) and its copolymers, polyurethanes, poly(lactic acid) and its copolymers, poly(ɛ-caprolactone), polyanhydrides, chitosan, cellulose, cyclodextrins, silk, conducting polymers, modified titanium surfaces, calcium phosphate based biomaterials, silicone and silica implants, as well as carbon nanotubes and graphene. To emphasize the applicability of regional chemotherapy in cancer treatment, the commercially available products approved by the relevant health agencies are presented.

Separation Science and Technology, 2016

The effect of oxygen conditioning on the performance of polyaniline (PANI) membranes is presented... more The effect of oxygen conditioning on the performance of polyaniline (PANI) membranes is presented and discussed. The presence of the conditioning effect in such kind of polymer matrix was confirmed by measuring a variation in spin concentration using EPR spectroscopy. The observed decrease in spin 10 concentration indicates the presence of the dissolved oxygen incompletely removed from PANI matrix. After the prolonged contact between oxygen and PANI membrane, a pronounced decrease in membrane’s selectivity was observed, which may be explained by the firm and permanent interaction between oxygen molecules and nitrogen paramagnetic centers of PANI and could be considered as a kind of PANI irreversible doping process.

Applied Surface Science, 2016

Bioelectrochemistry, 2016

As numerous therapeutic agents are not well tolerated when administrated systemically, localized ... more As numerous therapeutic agents are not well tolerated when administrated systemically, localized and controlled delivery can help to decrease their toxicity by applying an optimized drug concentration at extended exposure time. Among different types of drug delivery systems, conjugated polymers are considered as promising materials due to their biocompatibility, electrical conductivity and ability to undergo controllable redox reactions. In this work poly(3,4-ethylenedioxypyrrole), PEDOP, matrix is described for the first time as a reservoir of a model drug, ibuprofen (IBU). Drug immobilization process is performed in situ, during the electrochemical polymerization of 10 mM EDOP in the presence of 5-50 mM IBU. The loading efficiency of polymer matrix is dependent on IBU concentration and reaches 25.0±1.3 μg/cm2. The analysis of PEDOP-IBU chemical structure based on Raman spectroscopy, energy dispersive spectroscopy and surface morphology data provided by scanning electron microscopy shows that IBU is accumulated in the structure of matrix and evidently influences its morphology. IBU is then released in a controlled way under the influence of applied potential (-0.7 V vs. Ag/AgCl). It is demonstrated that the judicious choice of the synthesis conditions leads to a tailored loading efficiency of PEDOP matrix and to a tunable drug release.

Electrochemistry Communications, 2016

Związki zawierające ugrupowanie C-nitroazolowe są elementem struktury wielu leków o szerokim spek... more Związki zawierające ugrupowanie C-nitroazolowe są elementem struktury wielu leków o szerokim spektrum działania. Duża część z nich to związki o aktywności antypierwotniakowej i antybakteryjnej. Ta aktywność biologiczna wynika z zachodzącego w układach biologicznych procesu redukcji grupy nitrowej. Produkty pośrednie redukcji oddziałują na mikroorganizmy, powodując uszkodzenie ich DNA i zapobiegając ich dalszemu rozwojowi [1].

Chemioterapia jest jedną z najczęściej stosowanych metod leczenia chorób nowotworowych. Największ... more Chemioterapia jest jedną z najczęściej stosowanych metod leczenia chorób nowotworowych. Największą jej wadą są jednak skutki uboczne, tj. toksyczność względem zdrowych tkanek. Można tego uniknąć poprzez wykorzystanie miejscowych systemów dostarczania leków przeciwnowotworowych opartych na polimerach przewodzących. Związki te charakteryzują się zdolnościami jonowymiennymi, co jest szczególnie istotne przy immobilizacji i uwalnianiu związków o budowie jonowej. Triterpenoidy, to związki pochodzenia roślinnego o udowodnionym działaniu przeciwnowotworowym. Należący do tej grupy związków kwas oleanolowy wykazuje aktywność przeciwnowotworową w stosunku do linii komórkowych HeLa [5], L1210, K562 i HL-60, w różnych stadiach rozwoju nowotworu. W niniejszej pracy przedstawiono wyniki badań nad przewodzącymi matrycami polimerowymi zbudowanymi z poli(3,4-etylenodioksytiofenu), w których unieruchomione zostały cząsteczki kwasu oleanolowego. Immobilizacja przeprowadzona została z wykorzystaniem wo...

Following the interdisciplinary of the investigated phenomenon of self-heating it is necessary to... more Following the interdisciplinary of the investigated phenomenon of self-heating it is necessary to analyze the processes of structural modifications occurring in composites subjected to cyclic loading both from mechanical and chemical point of view for better understanding its degradation mechanisms. The paper presents experimental research results and analysis of structural degradation of polymer composites during occurrence of self-heating effect and thermal fatigue. Some characteristic aspects of the process were analyzed and discussed, i.e. structural changes in the polymer during occurrence of the selfheating effect, its connection with dynamic mechanical properties and thermokinetic laws and behaviour of the polymer when the glasstransition temperature is reached. Particularly, the process of residual cross-linking occurred during self-heating was analyzed; the results of experimental test were presented and interpreted following the chemical reactions, which occurred and have ...

One of the greatest challenges in neuroprosthetics is the specific design of the surface of neura... more One of the greatest challenges in neuroprosthetics is the specific design of the surface of neural implant [1]. Apart from exhibiting desired electrical properties and electrochemical stability, it should also be biocompatible. Numerous studies have shown that some conjugated polymers, mainly polypyrrole and poly(3,4-ethylenedioxythiophene), do not cause adverse effects, such as inflammation or immunological reaction, when introduced into tissues [2]. Because of the fact that conjugated polymers exhibit ion-exchangeable properties, it is possible to immobilize biologically active compounds of ionic nature in a conducting polymer matrix [3]. The ability to release biomolecules in a controlled manner realizes the concept of smart drug delivery systems [4]. The aim of this work was to design biologically active and conducting coating that may be utilized in neuroprosthetics. Poly(3,4-ethylenedioxythiophene), PEDOT, was chosen as a matrix, while sodium iso-butyl-propanoic-phenolate, IBU...

The discovery of intrinsically conducting polymers in 1977 by Shirakawa was a breakthrough in ele... more The discovery of intrinsically conducting polymers in 1977 by Shirakawa was a breakthrough in electrochemistry. Nowadays, conjugated polymers are widely known for their electrical properties and have found numerous applications in areas such as: organic solar cells, organic light-emitting diodes, supercapacitors, actuators, etc. Beside a great success of conducting polymers in electronics, they have been considered as materials for biomedical engineering. For the latest decade, numerous issues were proposed on this field like biosensors, artificial muscles, coatings for neuroprosthetics, drug delivery systems – all of them based on conducting polymers. It turned out that the choice of these materials was an unquestionable success. Selected conducting polymers, among them polypyrrole and poly(3,4-ethylenedioxythiophene), were proven as biocompatible and therefore neutral when introduced into a human body. The ability of these structures to conduct electricity is their additional adva...