fabio fin | Universidade Positivo (original) (raw)

Uploads

Papers by fabio fin

Journal of Clinical Oncology

e17587 Background: PARP inhibitors (PARPi) have been approved for maintenance therapy in newly di... more e17587 Background: PARP inhibitors (PARPi) have been approved for maintenance therapy in newly diagnosed ovarian cancer patients with or without homologous recombination deficiency (HRD). In this meta-analysis, the latest clinical data to assess the efficacy and safety of this approach across different subgroups were synthesized. Methods: PubMed, Scopus, and Cochrane databases were searched for randomized controlled trials that compared maintenance PARPi with placebo in newly diagnosed ovarian cancer. The outcomes of interest included progression-free survival (PFS) according to HRD status, overall survival (OS), second PFS (PFS2), and time-to-first subsequent treatment (TFST). Heterogeneity was examined with I2 statistics. A random-effects model was used for outcomes with high heterogeneity. Results: A total of 6 Randomized clinical trials with 3609 patients were included, of whom 2348 (65%) received maintenance PARPi. PFS was significantly longer for HRD-positive patients receivin...

Journal of Surgical Oncology, Jul 1, 2022

Os paragangliomas sao tumores originarios de celulas provenientes do sistema neuroendocrino. Assi... more Os paragangliomas sao tumores originarios de celulas provenientes do sistema neuroendocrino. Assim como o feocromocitoma, sao produtores de catecolaminas, entretanto diferem na sua localizacao que e extra-adrenal. O relato de caso presente e de uma paciente do sexo feminino, 25 anos, com quadro de dor abdominal, astenia e, ao exame fisico, lesao fixa e palpavel em mesogastrio de 4 cm. A investigacao diagnostica constatou, atraves da tomografia, uma imagem de massa retroperitonial junto aos gânglios de zuckerlandl. O tratamento cirurgico foi indicado. Durante a cirurgia apresentou sintomas adrenergicos com baixa resposta a drogas vasoativas. Apos a retirada por completo da lesao, cessaram os sintomas. A biopsia mostrou se tratar de paraganglioma maligno. O feocromocitoma apresenta grande espectro de sintomatologia clinicas, principalmente relacionados a liberacao de catecolaminas, repercutindo em alteracoes cardiovasculares, como crises hipertensivas. A unica forma de tratamento pote...

Journal of Minimally Invasive Gynecology

Journal of Surgical Oncology

BJOG : an international journal of obstetrics and gynaecology, Jan 14, 2018

Surgical management in epithelial ovarian cancer (EOC) has a significant impact in overall surviv... more Surgical management in epithelial ovarian cancer (EOC) has a significant impact in overall survival (OS) and progression free survival (PFS). Brazilian Society of Surgical Oncology (BSSO) supported a taskforce with experts for consensus: experienced and specialized trained surgeons, in cancer centers, provide the best EOC surgery. Laparoscopic and/or radiological staging prognosticate the possibility of complete cytoreduction (CC0) and help to reduce unnecessary laparotomies. Surgical techniques were reviewed. Multidisciplinary input is essential for treatment planning. Quality assurance criteria are proposed and need national consensus. Genetic testing is mandatory. This consensus states the final recommendations from BSSO for management of EOC. This article is protected by copyright. All rights reserved.

Revista Do Medico Residente, Jan 3, 2010

Revista Do Medico Residente, Jan 6, 2013