Jobin Varkey • USC Profiles (original) (raw)

  1. TDP43 and huntingtin Exon-1 undergo a conformationally specific interaction that strongly alters the fibril formation of both proteins. J Biol Chem. 2024 09; 300(9):107660. George G, Ajayan A, Varkey J, Pandey NK, Chen J, Langen R. PMID: 39128727; PMCID: PMC11408864.
    View in: PubMed Mentions: 2 Fields:
    Translation:HumansCells
  2. Retraction Note: Pericyte degeneration causes white matter dysfunction in the mouse central nervous system. Nat Med. 2024 Apr; 30(4):1215. Montagne A, Nikolakopoulou AM, Zhao Z, Sagare AP, Si G, Lazic D, Barnes SR, Daianu M, Ramanathan A, Go A, Lawson EJ, Wang Y, Mack WJ, Thompson PM, Schneider JA, Varkey J, Langen R, Mullins E, Jacobs RE, Zlokovic BV. PMID: 38580816; PMCID: PMC11036445.
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  3. Fluorescent protein tagging promotes phase separation and alters the aggregation pathway of huntingtin exon-1. J Biol Chem. 2024 01; 300(1):105585. Pandey NK, Varkey J, Ajayan A, George G, Chen J, Langen R. PMID: 38141760; PMCID: PMC10825056.
    View in: PubMed Mentions: 16 Fields:
    Translation:Humans
  4. Molecular basis of Q-length selectivity for the MW1 antibody-huntingtin interaction. J Biol Chem. 2023 04; 299(4):104616. Bravo-Arredondo JM, Venkataraman R, Varkey J, Isas JM, Situ AJ, Xu H, Chen J, Ulmer TS, Langen R. PMID: 36931390; PMCID: PMC10124945.
    View in: PubMed Mentions: 3 Fields:
    Translation:HumansCells
  5. An Amphipathic Alpha-Helix Domain from Poliovirus 2C Protein Tubulate Lipid Vesicles. Viruses. 2020 12 18; 12(12). Varkey J, Zhang J, Kim J, George G, He G, Belov G, Langen R, Wang X. PMID: 33353144; PMCID: PMC7766222.
    View in: PubMed Mentions: 7 Fields:
    Translation:HumansCells
  6. Structural Model of the Proline-Rich Domain of Huntingtin Exon-1 Fibrils. Biophys J. 2020 11 17; 119(10):2019-2028. Falk AS, Bravo-Arredondo JM, Varkey J, Pacheco S, Langen R, Siemer AB. PMID: 33096080; PMCID: PMC7732765.
    View in: PubMed Mentions: 10 Fields:
    Translation:Humans
  7. E46K-like α-synuclein mutants increase lipid interactions and disrupt membrane selectivity. J Biol Chem. 2019 06 21; 294(25):9799-9812. Rovere M, Powers AE, Jiang H, Pitino JC, Fonseca-Ornelas L, Patel DS, Achille A, Langen R, Varkey J, Bartels T. PMID: 31048377; PMCID: PMC6597829.
    View in: PubMed Mentions: 30 Fields:
    Translation:HumansCells
  8. Construction of Parkinson's disease marker-based weighted protein-protein interaction network for prioritization of co-expressed genes. Gene. 2019 May 20; 697:67-77. George G, Valiya Parambath S, Lokappa SB, Varkey J. PMID: 30776463.
    View in: PubMed Mentions: 12 Fields:
    Translation:HumansCells
  9. Gene co-expression network analysis for identifying genetic markers in Parkinson's disease - a three-way comparative approach. Genomics. 2019 07; 111(4):819-830. George G, Singh S, Lokappa SB, Varkey J. PMID: 29852216.
    View in: PubMed Mentions: 28 Fields:
    Translation:HumansCells
  10. Membranes as modulators of amyloid protein misfolding and target of toxicity. Biochim Biophys Acta Biomembr. 2018 Sep; 1860(9):1863-1875. Rawat A, Langen R, Varkey J. PMID: 29702073; PMCID: PMC6203680.
    View in: PubMed Mentions: 20 Fields:
  11. Pericyte degeneration causes white matter dysfunction in the mouse central nervous system. Nat Med. 2018 03; 24(3):326-337. Montagne A, Nikolakopoulou AM, Zhao Z, Sagare AP, Si G, Lazic D, Barnes SR, Daianu M, Ramanathan A, Go A, Lawson EJ, Wang Y, Mack WJ, Thompson PM, Schneider JA, Varkey J, Langen R, Mullins E, Jacobs RE, Zlokovic BV. PMID: 29400711; PMCID: PMC5840035.
    View in: PubMed Mentions: 214 Fields:
    Translation:HumansAnimalsCells
  12. Membrane remodeling by amyloidogenic and non-amyloidogenic proteins studied by EPR. J Magn Reson. 2017 07; 280:127-139. Varkey J, Langen R. PMID: 28579098; PMCID: PMC5461824.
    View in: PubMed Mentions: 5 Fields:
    Translation:HumansAnimals
  13. α-Synuclein Amyloid Fibrils with Two Entwined, Asymmetrically Associated Protofibrils. J Biol Chem. 2016 Jan 29; 291(5):2310-8. Dearborn AD, Wall JS, Cheng N, Heymann JB, Kajava AV, Varkey J, Langen R, Steven AC. PMID: 26644467; PMCID: PMC4732214.
    View in: PubMed Mentions: 28 Fields:
    Translation:HumansCells
  14. Early sodium dodecyl sulfate induced collapse of α-synuclein correlates with its amyloid formation. ACS Chem Neurosci. 2015 Feb 18; 6(2):239-46. Basak S, Prasad GV, Varkey J, Chattopadhyay K. PMID: 25369246.
    View in: PubMed Mentions: 4 Fields:
    Translation:Cells
  15. Nonaggregated α-synuclein influences SNARE-dependent vesicle docking via membrane binding. Biochemistry. 2014 Jun 24; 53(24):3889-96. Lai Y, Kim S, Varkey J, Lou X, Song JK, Diao J, Langen R, Shin YK. PMID: 24884175; PMCID: PMC4075992.
    View in: PubMed Mentions: 48 Fields:
    Translation:Cells
  16. Hydration dynamics as an intrinsic ruler for refining protein structure at lipid membrane interfaces. Proc Natl Acad Sci U S A. 2013 Oct 15; 110(42):16838-43. Cheng CY, Varkey J, Ambroso MR, Langen R, Han S. PMID: 24082088; PMCID: PMC3800990.
    View in: PubMed Mentions: 36 Fields:
    Translation:HumansCells
  17. α-Synuclein oligomers with broken helical conformation form lipoprotein nanoparticles. J Biol Chem. 2013 Jun 14; 288(24):17620-30. Varkey J, Mizuno N, Hegde BG, Cheng N, Steven AC, Langen R. PMID: 23609437; PMCID: PMC3682563.
    View in: PubMed Mentions: 43 Fields:
    Translation:HumansCells
  18. Rational design of potent domain antibody inhibitors of amyloid fibril assembly. Proc Natl Acad Sci U S A. 2012 Dec 04; 109(49):19965-70. Ladiwala AR, Bhattacharya M, Perchiacca JM, Cao P, Raleigh DP, Abedini A, Schmidt AM, Varkey J, Langen R, Tessier PM. PMID: 23161913; PMCID: PMC3523860.
    View in: PubMed Mentions: 44 Fields:
    Translation:HumansCells
  19. Remodeling of lipid vesicles into cylindrical micelles by α-synuclein in an extended α-helical conformation. J Biol Chem. 2012 Aug 24; 287(35):29301-11. Mizuno N, Varkey J, Kegulian NC, Hegde BG, Cheng N, Langen R, Steven AC. PMID: 22767608; PMCID: PMC3436199.
    View in: PubMed Mentions: 58 Fields:
    Translation:HumansCells
  20. Semisynthetic, site-specific ubiquitin modification of α-synuclein reveals differential effects on aggregation. J Am Chem Soc. 2012 Mar 28; 134(12):5468-71. Meier F, Abeywardana T, Dhall A, Marotta NP, Varkey J, Langen R, Chatterjee C, Pratt MR. PMID: 22404520; PMCID: PMC3315850.
    View in: PubMed Mentions: 64 Fields:
    Translation:HumansCells
  21. Membrane curvature induction and tubulation are common features of synucleins and apolipoproteins. J Biol Chem. 2010 Oct 15; 285(42):32486-93. Varkey J, Isas JM, Mizuno N, Jensen MB, Bhatia VK, Jao CC, Petrlova J, Voss JC, Stamou DG, Steven AC, Langen R. PMID: 20693280; PMCID: PMC2952250.
    View in: PubMed Mentions: 178 Fields:
    Translation:HumansAnimalsCells
  22. Antibacterial activity of linear peptides spanning the carboxy-terminal beta-sheet domain of arthropod defensins. Peptides. 2006 Nov; 27(11):2614-23. Varkey J, Singh S, Nagaraj R. PMID: 16914230.
    View in: PubMed Mentions: 7 Fields:
    Translation:AnimalsCells
  23. Antibacterial activity of human neutrophil defensin HNP-1 analogs without cysteines. Antimicrob Agents Chemother. 2005 Nov; 49(11):4561-6. Varkey J, Nagaraj R. PMID: 16251296; PMCID: PMC1280114.
    View in: PubMed Mentions: 37 Fields:
    Translation:HumansCells

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This graph shows the number and percent of publications by field. Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications. Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written. To see the data as text, click here.

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