Liana Asatryan • USC Profiles (original) (raw)

  1. Preclinical Evaluation of Sodium Butyrate's Potential to Reduce Alcohol Consumption: A Dose-Escalation Study in C57BL/6J Mice in Antibiotic-Enhanced Binge-Like Drinking Model. Pharmacology. 2025; 110(1):36-48. Havton GC, Tai ATC, Vasisht S, Davies DL, Asatryan L. PMID: 39134007; PMCID: PMC11794028.
    View in: PubMed Mentions: 1 Fields:
    Translation:Animals
  2. Dihydromyricetin supplementation improves ethanol-induced lipid accumulation and inflammation. Front Nutr. 2023; 10:1201007. Janilkarn-Urena I, Idrissova A, Zhang M, VanDreal M, Sanghavi N, Skinner SG, Cheng S, Zhang Z, Watanabe J, Asatryan L, Cadenas E, Davies DL. PMID: 37680900; PMCID: PMC10481966.
    View in: PubMed Mentions: 7
  3. Sodium Butyrate Supplementation Modulates Neuroinflammatory Response Aggravated by Antibiotic Treatment in a Mouse Model of Binge-like Ethanol Drinking. Int J Mol Sci. 2022 Dec 10; 23(24). Gao L, Davies DL, Asatryan L. PMID: 36555338; PMCID: PMC9778941.
    View in: PubMed Mentions: 12 Fields:
    Translation:Animals
  4. Supplementation with sodium butyrate protects against antibiotic-induced increases in ethanol consumption behavior in mice. Alcohol. 2022 05; 100:1-9. Reyes RE, Gao L, Zhang Z, Davies DL, Asatryan L. PMID: 34999234; PMCID: PMC8983552.
    View in: PubMed Mentions: 11 Fields:
    Translation:Animals
  5. Cross-Talk between P2X and NMDA Receptors. Int J Mol Sci. 2020 Sep 29; 21(19). Rodriguez L, Yi C, Chu C, Duriez Q, Watanabe S, Ryu M, Reyes B, Asatryan L, Boué-Grabot E, Davies D. PMID: 33003406; PMCID: PMC7582700.
    View in: PubMed Mentions: 12 Fields:
    Translation:AnimalsCells
  6. Antibiotic-induced disruption of commensal microbiome linked to increases in binge-like ethanol consumption behavior. Brain Res. 2020 11 15; 1747:147067. Reyes REN, Al Omran AJ, Davies DL, Asatryan L. PMID: 32827548; PMCID: PMC8480222.
    View in: PubMed Mentions: 17 Fields:
    Translation:Animals
  7. A novel pharmacotherapy approach using P-glycoprotein (PGP/ABCB1) efflux inhibitor combined with ivermectin to reduce alcohol drinking and preference in mice. Alcohol. 2020 08; 86:1-8. Silva J, Khoja S, Asatryan L, Pacifici E, Davies DL. PMID: 32278067; PMCID: PMC7292774.
    View in: PubMed Mentions: 2 Fields:
    Translation:Animals
  8. Residues in Transmembrane Segments of the P2X4 Receptor Contribute to Channel Function and Ethanol Sensitivity. Int J Mol Sci. 2020 Apr 02; 21(7). Popova M, Rodriguez L, Trudell JR, Nguyen S, Bloomfield M, Davies DL, Asatryan L. PMID: 32252459; PMCID: PMC7178174.
    View in: PubMed Mentions: 5 Fields:
    Translation:Cells
  9. Dopamine Receptor Blockade Attenuates Purinergic P2X4 Receptor-Mediated Prepulse Inhibition Deficits and Underlying Molecular Mechanisms. Front Cell Neurosci. 2019; 13:331. Khoja S, Asatryan L, Jakowec MW, Davies DL. PMID: 31396053; PMCID: PMC6664007.
    View in: PubMed Mentions: 12
  10. Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice. J Vis Exp. 2019 01 07; (143). Huynh N, Arabian NM, Asatryan L, Davies DL. PMID: 30663649; PMCID: PMC6524528.
    View in: PubMed Mentions: 10 Fields:
    Translation:HumansAnimals
  11. Similarities in Blood Mononuclear Cell Membrane Phospholipid Profiles During Malignancy. Med Sci (Basel). 2018 Nov 23; 6(4). Hakobyan G, Davtyan H, Harutyunyan K, Alexanyan K, Amirkhanyan Y, Gharibyan AL, Asatryan L, Tadevosyan Y. PMID: 30477187; PMCID: PMC6313534.
    View in: PubMed Mentions: Fields:
  12. P2X7 Receptor Antagonist A804598 Inhibits Inflammation in Brain and Liver in C57BL/6J Mice Exposed to Chronic Ethanol and High Fat Diet. J Neuroimmune Pharmacol. 2019 06; 14(2):263-277. Freire D, Reyes RE, Baghram A, Davies DL, Asatryan L. PMID: 30353422; PMCID: PMC6494709.
    View in: PubMed Mentions: 18 Fields:
    Translation:AnimalsCells
  13. Preclinical evaluation of avermectins as novel therapeutic agents for alcohol use disorders. Psychopharmacology (Berl). 2018 06; 235(6):1697-1709. Khoja S, Huynh N, Warnecke AMP, Asatryan L, Jakowec MW, Davies DL. PMID: 29500584; PMCID: PMC5949264.
    View in: PubMed Mentions: 11 Fields:
    Translation:HumansAnimals
  14. Reduced expression of purinergic P2X4 receptors increases voluntary ethanol intake in C57BL/6J mice. Alcohol. 2018 05; 68:63-70. Khoja S, Huynh N, Asatryan L, Jakowec MW, Davies DL. PMID: 29477921; PMCID: PMC5878121.
    View in: PubMed Mentions: 9 Fields:
    Translation:Animals
  15. Ethanol differentially modulates P2X4 and P2X7 receptor activity and function in BV2 microglial cells. Neuropharmacology. 2018 Jan; 128:11-21. Asatryan L, Ostrovskaya O, Lieu D, Davies DL. PMID: 28943285; PMCID: PMC6492934.
    View in: PubMed Mentions: 30 Fields:
    Translation:AnimalsCells
  16. Preclinical development of moxidectin as a novel therapeutic for alcohol use disorder. Neuropharmacology. 2017 02; 113(Pt A):60-70. Huynh N, Arabian N, Naito A, Louie S, Jakowec MW, Asatryan L, Davies DL. PMID: 27641072; PMCID: PMC5148646.
    View in: PubMed Mentions: 15 Fields:
    Translation:Animals
  17. Role of purinergic P2X4 receptors in regulating striatal dopamine homeostasis and dependent behaviors. J Neurochem. 2016 10; 139(1):134-48. Khoja S, Shah V, Garcia D, Asatryan L, Jakowec MW, Davies DL. PMID: 27402173; PMCID: PMC5037001.
    View in: PubMed Mentions: 29 Fields:
    Translation:AnimalsCells
  18. Utilizing an Orally Dissolving Strip for Pharmacological and Toxicological Studies: A Simple and Humane Alternative to Oral Gavage for Animals. J Vis Exp. 2016 Mar 23; (109):e53770. Huynh N, Arabian N, Lieu D, Asatryan L, Davies DL. PMID: 27078261; PMCID: PMC4841306.
    View in: PubMed Mentions: 1 Fields:
    Translation:Animals
  19. Epigenetic control of group V phospholipase A2 expression in human malignant cells. Tumour Biol. 2016 Jun; 37(6):8097-105. Menschikowski M, Hagelgans A, Nacke B, Jandeck C, Mareninova OA, Asatryan L, Siegert G. PMID: 26715269.
    View in: PubMed Mentions: 7 Fields:
    Translation:HumansCells
  20. Chronic ethanol exposure combined with high fat diet up-regulates P2X7 receptors that parallels neuroinflammation and neuronal loss in C57BL/6J mice. J Neuroimmunol. 2015 Aug 15; 285:169-79. Asatryan L, Khoja S, Rodgers KE, Alkana RL, Tsukamoto H, Davies DL. PMID: 26198936; PMCID: PMC4512299.
    View in: PubMed Mentions: 15 Fields:
    Translation:AnimalsCells
  21. Manipulations of extracellular Loop 2 in α1 GlyR ultra-sensitive ethanol receptors (USERs) enhance receptor sensitivity to isoflurane, ethanol, and lidocaine, but not propofol. Neuroscience. 2015 Jun 25; 297:68-77. Naito A, Muchhala KH, Trang J, Asatryan L, Trudell JR, Homanics GE, Alkana RL, Davies DL. PMID: 25827497; PMCID: PMC4428915.
    View in: PubMed Mentions: 4 Fields:
    Translation:AnimalsCells
  22. Glycine and GABA(A) ultra-sensitive ethanol receptors as novel tools for alcohol and brain research. Mol Pharmacol. 2014 Dec; 86(6):635-46. Naito A, Muchhala KH, Asatryan L, Trudell JR, Homanics GE, Perkins DI, Davies DL, Alkana RL. PMID: 25245406; PMCID: PMC4244596.
    View in: PubMed Mentions: 10 Fields:
    Translation:Animals
  23. Multiday administration of ivermectin is effective in reducing alcohol intake in mice at doses shown to be safe in humans. Neuroreport. 2014 Sep 10; 25(13):1018-23. Yardley MM, Neely M, Huynh N, Asatryan L, Louie SG, Alkana RL, Davies DL. PMID: 25004078; PMCID: PMC4126080.
    View in: PubMed Mentions: 10 Fields:
    Translation:Animals
  24. P2X4 receptors (P2X4Rs) represent a novel target for the development of drugs to prevent and/or treat alcohol use disorders. Front Neurosci. 2014; 8:176. Franklin KM, Asatryan L, Jakowec MW, Trudell JR, Bell RL, Davies DL. PMID: 25009459; PMCID: PMC4068020.
    View in: PubMed Mentions: 37
  25. Contribution of P2X4 receptors to ethanol intake in male C57BL/6 mice. Neurochem Res. 2014 Jun; 39(6):1127-39. Wyatt LR, Finn DA, Khoja S, Yardley MM, Asatryan L, Alkana RL, Davies DL. PMID: 24671605; PMCID: PMC4031031.
    View in: PubMed Mentions: 31 Fields:
    Translation:Animals
  26. Avermectins differentially affect ethanol intake and receptor function: implications for developing new therapeutics for alcohol use disorders. Int J Neuropsychopharmacol. 2014 Jun; 17(6):907-16. Asatryan L, Yardley MM, Khoja S, Trudell JR, Hyunh N, Louie SG, Petasis NA, Alkana RL, Davies DL. PMID: 24451653; PMCID: PMC4209915.
    View in: PubMed Mentions: 19 Fields:
    Translation:Animals
  27. Serum amyloid A, phospholipase A₂-IIA and C-reactive protein as inflammatory biomarkers for prostate diseases. Inflamm Res. 2013 Dec; 62(12):1063-72. Menschikowski M, Hagelgans A, Fuessel S, Mareninova OA, Asatryan L, Wirth MP, Siegert G. PMID: 24061501.
    View in: PubMed Mentions: 8 Fields:
    Translation:HumansCells
  28. Tryptophan 46 is a site for ethanol and ivermectin action in P2X4 receptors. Purinergic Signal. 2013 Dec; 9(4):621-32. Popova M, Trudell J, Li K, Alkana R, Davies D, Asatryan L. PMID: 23817978; PMCID: PMC3889384.
    View in: PubMed Mentions: 23 Fields:
    Translation:AnimalsCells
  29. Pharmacological insights into the role of P2X4 receptors in behavioural regulation: lessons from ivermectin. Int J Neuropsychopharmacol. 2013 Jun; 16(5):1059-70. Bortolato M, Yardley MM, Khoja S, Godar SC, Asatryan L, Finn DA, Alkana RL, Louie SG, Davies DL. PMID: 23174033; PMCID: PMC3593990.
    View in: PubMed Mentions: 33 Fields:
    Translation:Animals
  30. Ivermectin reduces alcohol intake and preference in mice. Neuropharmacology. 2012 Aug; 63(2):190-201. Yardley MM, Wyatt L, Khoja S, Asatryan L, Ramaker MJ, Finn DA, Alkana RL, Huynh N, Louie SG, Petasis NA, Bortolato M, Davies DL. PMID: 22465817; PMCID: PMC3372603.
    View in: PubMed Mentions: 44 Fields:
    Translation:Animals
  31. Charge and geometry of residues in the loop 2 β hairpin differentially affect agonist and ethanol sensitivity in glycine receptors. J Pharmacol Exp Ther. 2012 May; 341(2):543-51. Perkins DI, Trudell JR, Asatryan L, Davies DL, Alkana RL. PMID: 22357974; PMCID: PMC3336819.
    View in: PubMed Mentions: 12 Fields:
    Translation:HumansAnimalsCells
  32. Implication of the purinergic system in alcohol use disorders. Alcohol Clin Exp Res. 2011 Apr; 35(4):584-94. Asatryan L, Nam HW, Lee MR, Thakkar MM, Saeed Dar M, Davies DL, Choi DS. PMID: 21223299; PMCID: PMC3076125.
    View in: PubMed Mentions: 40 Fields:
    Translation:HumansAnimalsCells
  33. Ethanol is a fast channel inhibitor of P2X4 receptors. J Pharmacol Exp Ther. 2011 Apr; 337(1):171-9. Ostrovskaya O, Asatryan L, Wyatt L, Popova M, Li K, Peoples RW, Alkana RL, Davies DL. PMID: 21212160; PMCID: PMC3063738.
    View in: PubMed Mentions: 27 Fields:
    Translation:HumansAnimalsCells
  34. Ivermectin antagonizes ethanol inhibition in purinergic P2X4 receptors. J Pharmacol Exp Ther. 2010 Sep 01; 334(3):720-8. Asatryan L, Popova M, Perkins D, Trudell JR, Alkana RL, Davies DL. PMID: 20543096; PMCID: PMC2939657.
    View in: PubMed Mentions: 38 Fields:
    Translation:AnimalsCells
  35. A point mutation in the ectodomain-transmembrane 2 interface eliminates the inhibitory effects of ethanol in P2X4 receptors. J Neurochem. 2010 Jan; 112(1):307-17. Popova M, Asatryan L, Ostrovskaya O, Wyatt LR, Li K, Alkana RL, Davies DL. PMID: 19878433; PMCID: PMC2809143.
    View in: PubMed Mentions: 28 Fields:
    Translation:AnimalsCells
  36. Loop 2 structure in glycine and GABA(A) receptors plays a key role in determining ethanol sensitivity. J Biol Chem. 2009 Oct 02; 284(40):27304-14. Perkins DI, Trudell JR, Crawford DK, Asatryan L, Alkana RL, Davies DL. PMID: 19656948; PMCID: PMC2785658.
    View in: PubMed Mentions: 32 Fields:
    Translation:HumansAnimalsCells
  37. LDL protein nitration: implication for LDL protein unfolding. Arch Biochem Biophys. 2008 Nov 01; 479(1):1-14. Hamilton RT, Asatryan L, Nilsen JT, Isas JM, Gallaher TK, Sawamura T, Hsiai TK. PMID: 18713619; PMCID: PMC2649963.
    View in: PubMed Mentions: 17 Fields:
    Translation:HumansAnimalsCells
  38. Roles of ectodomain and transmembrane regions in ethanol and agonist action in purinergic P2X2 and P2X3 receptors. Neuropharmacology. 2008 Oct; 55(5):835-43. Asatryan L, Popova M, Woodward JJ, King BF, Alkana RL, Davies DL. PMID: 18639563; PMCID: PMC2629788.
    View in: PubMed Mentions: 17 Fields:
    Translation:AnimalsCells
  39. Effects of ethanol on adenosine 5'-triphosphate-gated purinergic and 5-hydroxytryptamine receptors. Alcohol Clin Exp Res. 2006 Feb; 30(2):349-58. Davies DL, Asatryan L, Kuo ST, Woodward JJ, King BF, Alkana RL, Xiao C, Ye JH, Sun H, Zhang L, Hu XQ, Hayrapetyan V, Lovinger DM, Machu TK. PMID: 16441284; PMCID: PMC1448702.
    View in: PubMed Mentions: 12 Fields:
    Translation:HumansAnimalsCells
  40. High-density lipoprotein hydrolysis by endothelial lipase activates PPARalpha: a candidate mechanism for high-density lipoprotein-mediated repression of leukocyte adhesion. Circ Res. 2006 Mar 03; 98(4):490-8. Ahmed W, Orasanu G, Nehra V, Asatryan L, Rader DJ, Ziouzenkova O, Plutzky J. PMID: 16439686; PMCID: PMC4231787.
    View in: PubMed Mentions: 31 Fields:
    Translation:HumansAnimalsCells
  41. Role of annexin II in estrogen-induced macrophage matrix metalloproteinase-9 activity: the modulating effect of statins. Atherosclerosis. 2006 Nov; 189(1):76-82. Hwang J, Hodis HN, Hsiai TK, Asatryan L, Sevanian A. PMID: 16386257.
    View in: PubMed Mentions: 13 Fields:
    Translation:HumansCells
  42. LDL phospholipid hydrolysis produces modified electronegative particles with an unfolded apoB-100 protein. J Lipid Res. 2005 Jan; 46(1):115-22. Asatryan L, Hamilton RT, Isas JM, Hwang J, Kayed R, Sevanian A. PMID: 15489541; PMCID: PMC3383313.
    View in: PubMed Mentions: 13 Fields:
    Translation:HumansCells
  43. Dual roles for lipolysis and oxidation in peroxisome proliferation-activator receptor responses to electronegative low density lipoprotein. J Biol Chem. 2003 Oct 10; 278(41):39874-81. Ziouzenkova O, Asatryan L, Sahady D, Orasanu G, Perrey S, Cutak B, Hassell T, Akiyama TE, Berger JP, Sevanian A, Plutzky J. PMID: 12878589; PMCID: PMC4231711.
    View in: PubMed Mentions: 14 Fields:
    Translation:HumansAnimalsCells
  44. Heme and lipid peroxides in hemoglobin-modified low-density lipoprotein mediate cell survival and adaptation to oxidative stress. Blood. 2003 Sep 01; 102(5):1732-9. Asatryan L, Ziouzenkova O, Duncan R, Sevanian A. PMID: 12750169.
    View in: PubMed Mentions: 6 Fields:
    Translation:HumansAnimalsCells
  45. Lipolysis of triglyceride-rich lipoproteins generates PPAR ligands: evidence for an antiinflammatory role for lipoprotein lipase. Proc Natl Acad Sci U S A. 2003 Mar 04; 100(5):2730-5. Ziouzenkova O, Perrey S, Asatryan L, Hwang J, MacNaul KL, Moller DE, Rader DJ, Sevanian A, Zechner R, Hoefler G, Plutzky J. PMID: 12606719; PMCID: PMC151409.
    View in: PubMed Mentions: 81 Fields:
    Translation:HumansAnimalsCells
  46. Oxidative stress during ex vivo hemodialysis of blood is decreased by a novel hemolipodialysis procedure utilizing antioxidants. Free Radic Biol Med. 2002 Jul 15; 33(2):248-58. Ziouzenkova O, Asatryan L, Tetta C, Wratten ML, Hwang J, Sevanian A. PMID: 12106820.
    View in: PubMed Mentions: 2 Fields:
    Translation:HumansCells
  47. LDL modification during hemodialysis. Markers for oxidative stress. Contrib Nephrol. 2002; (137):386-95. Sevanian A, Asatryan L. PMID: 12101983.
    View in: PubMed Mentions: 1 Fields:
    Translation:HumansCells
  48. Differential role of cytosolic phospholipase A2 in the invasion of brain microvascular endothelial cells by Escherichia coli and Listeria monocytogenes. J Infect Dis. 2001 Sep 15; 184(6):732-7. Das A, Asatryan L, Reddy MA, Wass CA, Stins MF, Joshi S, Bonventre JV, Kim KS. PMID: 11517434.
    View in: PubMed Mentions: 22 Fields:
    Translation:HumansCells
  49. Oxidative cross-linking of ApoB100 and hemoglobin results in low density lipoprotein modification in blood. Relevance to atherogenesis caused by hemodialysis. J Biol Chem. 1999 Jul 02; 274(27):18916-24. Ziouzenkova O, Asatryan L, Akmal M, Tetta C, Wratten ML, Loseto-Wich G, Jürgens G, Heinecke J, Sevanian A. PMID: 10383389.
    View in: PubMed Mentions: 16 Fields:
    Translation:HumansCells
  50. Oxidative stress resulting from hemolysis and formation of catalytically active hemoglobin: protective strategies. Int J Clin Pharmacol Ther. 1999 Mar; 37(3):125-32. Ziouzenkova O, Asatryan L, Sevanian A. PMID: 10190760.
    View in: PubMed Mentions: 3 Fields:
    Translation:Humans
  51. Low density lipoprotein (LDL) modification: basic concepts and relationship to atherosclerosis. Blood Purif. 1999; 17(2-3):66-78. Sevanian A, Asatryan L, Ziouzenkova O. PMID: 10449864.
    View in: PubMed Mentions: 8 Fields:
    Translation:HumansAnimalsCells
  52. The effect of ribosomal peptidyl-transferase inhibitors is antagonized by elongation factor G with GTP. FEBS Lett. 1976 Nov; 70(1):101-4. Spirin AS, Asatryan LS. PMID: 791676.
    View in: PubMed Mentions: Fields:
    Translation:Cells
  53. Non-enzymatic translocation in ribosomes from streptomycin-resistant mutants of Escherichia coli. Mol Gen Genet. 1975 Jul 10; 138(4):315-21. Asatryan LS, Spirin AS. PMID: 1097889.
    View in: PubMed Mentions: 8 Fields:
    Translation:Cells

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