Marc Vermulst • USC Profiles (original) (raw)

  1. Induction of ferroptotic and amyloidogenic signatures linked to Alzheimer's disease by chemically distinct air pollutants. bioRxiv. 2026 Jan 07. Shkirkova K, Maria NSS, Anson H, Aghaei Y, Badami MM, Chakhoyan A, Godoy-Lugo JA, Chung C, Durra S, Tang-Tan A, Zhao L, Demetriou A, Morales M, Daggupati S, Bent I, Park H, Franklin C, Chen S, Chahine G, Dodds-Lewis S, Morishita M, Jacobs RE, Gout JF, Mack WJ, Forman HJ, Benayoun BA, Vermulst M, Cohen MD, Campen M, Sioutas C, Mack WJ, Finch CE, Thorwald MA. PMID: 41542504; PMCID: PMC12803064.
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  2. The mutational landscape of SARS-CoV-2 provides new insight into viral evolution and fitness. Nat Commun. 2025 Jul 11; 16(1):6425. Symons J, Chung C, Verheijen BM, Shemtov SJ, de Jong D, Amatngalim G, Nijhuis M, Vermulst M, Gout JF. PMID: 40645940; PMCID: PMC12254267.
    View in: PubMed Mentions: 1 Fields:
    Translation:HumansCells
  3. A narrow range of transcript-error rates across the Tree of Life. Sci Adv. 2025 Jul 11; 11(28):eadv9898. Li W, Baehr S, Marasco M, Reyes L, Brister D, Pikaard CS, Gout JF, Vermulst M, Lynch M. PMID: 40644547; PMCID: PMC12248287.
    View in: PubMed Mentions: 1 Fields:
  4. The longevity effects of reduced IGF-1 signaling depend on the stability of the mitochondrial genome. bioRxiv. 2025 Jun 06. Shemtov SJ, McGann E, Carrillo L, Lee S, Anson H, Chung CS, Anagnostou ME, Lai GD, Verheijen BM, Wan J, Vorobyova I, Sanchez-Contreras M, Conover CA, Thorwald MA, Cohen P, Kennedy SR, Gout JF, Haroon S, Vermulst M. PMID: 40501628; PMCID: PMC12157428.
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  5. Down syndrome with Alzheimer's disease brains have increased iron and associated lipid peroxidation consistent with ferroptosis. Alzheimers Dement. 2025 Jun; 21(6):e70322. Thorwald MA, Godoy-Lugo JA, Kerstiens E, Garcia G, Kim M, Shemtov SJ, Silva J, Durra S, O'Day PA, Mack WJ, Hiniker A, Vermulst M, Benayoun BA, Higuchi-Sanabria R, Forman HJ, Head E, Finch CE. PMID: 40536124; PMCID: PMC12177674.
    View in: PubMed Mentions: 2 Fields:
    Translation:HumansCells
  6. The hidden costs of imperfection: transcription errors in protein aggregation diseases. Curr Opin Genet Dev. 2025 Aug; 93:102350. Sun Y, Vermulst M. PMID: 40300213; PMCID: PMC12277071.
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    Translation:HumansCells
  7. Down syndrome with Alzheimer's disease brains have increased iron and associated lipid peroxidation consistent with ferroptosis. bioRxiv. 2025 Feb 06. Thorwald MA, Godoy-Lugo JA, Kerstiens E, Garcia G, Kim M, Shemtov SJ, Silva J, Durra S, O'Day PA, Mack WJ, Hiniker A, Vermulst M, Benayoun BA, Higuchi-Sanabria R, Forman HJ, Head E, Finch CE. PMID: 39975068; PMCID: PMC11839036.
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  8. A Narrow Range of Transcript-error Rates Across the Tree of Life. bioRxiv. 2025 Jan 14. Li W, Baehr S, Marasco M, Reyes L, Brister D, Pikaard CS, Gout JF, Vermulst M, Lynch M. PMID: 39868080; PMCID: PMC11761650.
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  9. Linking Environmental Genotoxins to Neurodegenerative Diseases Through Transcriptional Mutagenesis. Int J Mol Sci. 2024 Oct 24; 25(21). Verheijen BM, Vermulst M. PMID: 39518982; PMCID: PMC11545915.
    View in: PubMed Mentions: 2 Fields:
    Translation:HumansAnimalsCells
  10. Transcript errors generate amyloid-like proteins in huwman cells. Nat Commun. 2024 10 07; 15(1):8676. Chung CS, Kou Y, Shemtov SJ, Verheijen BM, Flores I, Love K, Del Dosso A, Thorwald MA, Liu Y, Hicks D, Sun Y, Toney RG, Carrillo L, Nguyen MM, Biao H, Jin Y, Jauregui AM, Quiroz JD, Head E, Moore DL, Simpson S, Thomas KW, Coba MP, Li Z, Benayoun BA, Rosenthal JJC, Kennedy SR, Quadrato G, Gout JF, Chen L, Vermulst M. PMID: 39375347; PMCID: PMC11458900.
    View in: PubMed Mentions: 7 Fields:
    Translation:HumansCells
  11. MADDD-seq, a novel massively parallel sequencing tool for simultaneous detection of DNA damage and mutations. Nucleic Acids Res. 2024 Sep 09; 52(16):e76. Vermulst M, Paskvan SL, Chung CS, Franke K, Clegg N, Minot S, Madeoy J, Long AS, Gout JF, Bielas JH. PMID: 39149908; PMCID: PMC11381349.
    View in: PubMed Mentions: 2 Fields:
    Translation:AnimalsCells
  12. Effects of the glyphosate-based herbicide roundup on C. elegans and S. cerevisiae mortality, reproduction, and transcription fidelity. Environ Pollut. 2024 Sep 01; 356:124203. Dinep-Schneider O, Appiah E, Dapper A, Patterson S, Vermulst M, Gout JF. PMID: 38830529; PMCID: PMC11321929.
    View in: PubMed Mentions: 1 Fields:
    Translation:AnimalsCells
  13. Investigating impacts of the mycothiazole chemotype as a chemical probe for the study of mitochondrial function and aging. Geroscience. 2024 Dec; 46(6):6009-6028. Dutta N, Gerke JA, Odron SF, Morris JD, Hruby A, Kim J, Torres TC, Shemtov SJ, Clarke JG, Chang MC, Shaghasi H, Ray MN, Averbukh M, Hoang S, Oorloff M, Alcala A, Vega M, Mehta HH, Thorwald MA, Crews P, Vermulst M, Garcia G, Johnson TA, Higuchi-Sanabria R. PMID: 38570396; PMCID: PMC11493899.
    View in: PubMed Mentions: 4 Fields:
  14. The cycad genotoxin methylazoxymethanol, linked to Guam ALS/PDC, induces transcriptional mutagenesis. Acta Neuropathol Commun. 2024 02 21; 12(1):30. Verheijen BM, Chung C, Thompson B, Kim H, Nakahara A, Anink JJ, Mills JD, NYGC ALS Consortium, Lee JH, Aronica E, Oyanagi K, Kakita A, Gout JF, Vermulst M. PMID: 38383591; PMCID: PMC10882831.
    View in: PubMed Mentions: 7 Fields:
    Translation:Humans
  15. Tau filaments from amyotrophic lateral sclerosis/parkinsonism-dementia complex adopt the CTE fold. Proc Natl Acad Sci U S A. 2023 12 19; 120(51):e2306767120. Qi C, Verheijen BM, Kokubo Y, Shi Y, Tetter S, Murzin AG, Nakahara A, Morimoto S, Vermulst M, Sasaki R, Aronica E, Hirokawa Y, Oyanagi K, Kakita A, Ryskeldi-Falcon B, Yoshida M, Hasegawa M, Scheres SHW, Goedert M. PMID: 38100415; PMCID: PMC10743375.
    View in: PubMed Mentions: 21 Fields:
    Translation:Humans
  16. Investigating impacts of marine sponge derived mycothiazole and its acetylated derivative on mitochondrial function and aging. bioRxiv. 2023 Nov 27. Dutta N, Gerke JA, Odron SF, Morris JD, Hruby A, Castro Torres T, Shemtov SJ, Clarke JG, Chang MC, Shaghasi H, Ray MN, Averbukh M, Hoang S, Oorloff M, Alcala A, Vega M, Mehta HH, Thorwald MA, Crews P, Vermulst M, Garcia G, Johnson TA, Higuchi-Sanabria R. PMID: 38077060; PMCID: PMC10705228.
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  17. Identification of RBM46 as a novel APOBEC1 cofactor for C-to-U RNA-editing activity. J Mol Biol. 2023 12 15; 435(24):168333. Wang S, Kim K, Gelvez N, Chung C, Gout JF, Fixman B, Vermulst M, Chen XS. PMID: 38708190; PMCID: PMC11068304.
    View in: PubMed Mentions: 3 Fields:
    Translation:HumansCells
  18. Tau Filaments from Amyotrophic Lateral Sclerosis/Parkinsonism-Dementia Complex (ALS/PDC) adopt the CTE Fold. bioRxiv. 2023 Apr 28. Qi C, Verheijen BM, Kokubo Y, Shi Y, Tetter S, Murzin AG, Nakahara A, Morimoto S, Vermulst M, Sasaki R, Aronica E, Hirokawa Y, Oyanagi K, Kakita A, Ryskeldi-Falcon B, Yoshida M, Hasegawa M, Scheres SHW, Goedert M. PMID: 37162924; PMCID: PMC10168338.
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  19. Evolutionary conservation of the fidelity of transcription. Nat Commun. 2023 03 20; 14(1):1547. Chung C, Verheijen BM, Navapanich Z, McGann EG, Shemtov S, Lai GJ, Arora P, Towheed A, Haroon S, Holczbauer A, Chang S, Manojlovic Z, Simpson S, Thomas KW, Kaplan C, van Hasselt P, Timmers M, Erie D, Chen L, Gout JF, Vermulst M. PMID: 36941254; PMCID: PMC10027832.
    View in: PubMed Mentions: 13 Fields:
    Translation:HumansAnimalsCells
  20. The fidelity of transcription in human cells. Proc Natl Acad Sci U S A. 2023 01 31; 120(5):e2210038120. Chung C, Verheijen BM, Zhang X, Huang B, Coakley A, McGann E, Wade E, Dinep-Schneider O, LaGosh J, Anagnostou ME, Simpson S, Thomas K, Ernst M, Rattray A, Lynch M, Kashlev M, Benayoun BA, Li Z, Strathern J, Gout JF, Vermulst M. PMID: 36696440; PMCID: PMC9945944.
    View in: PubMed Mentions: 11 Fields:
    Translation:HumansAnimalsCells
  21. Genome-wide surveillance of transcription errors in response to genotoxic stress. Proc Natl Acad Sci U S A. 2021 01 05; 118(1). Fritsch C, Gout JF, Haroon S, Towheed A, Chung C, LaGosh J, McGann E, Zhang X, Song Y, Simpson S, Danthi PS, Benayoun BA, Wallace D, Thomas K, Lynch M, Vermulst M. PMID: 33443141; PMCID: PMC7817157.
    View in: PubMed Mentions: 19 Fields:
    Translation:HumansCells
  22. Correction to: Somatic mutations in neurons during aging and neurodegeneration. Acta Neuropathol. 2020 09; 140(3):415. Verheijen BM, Vermulst M, van Leeuwen FW. PMID: 32632518; PMCID: PMC7423787.
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  23. Unexpected cell type-dependent effects of autophagy on polyglutamine aggregation revealed by natural genetic variation in C. elegans. BMC Biol. 2020 02 24; 18(1):18. Alexander-Floyd J, Haroon S, Ying M, Entezari AA, Jaeger C, Vermulst M, Gidalevitz T. PMID: 32093691; PMCID: PMC7038566.
    View in: PubMed Mentions: 12 Fields:
    Translation:Animals
  24. Increased burden of mitochondrial DNA deletions and point mutations in early-onset age-related hearing loss in mitochondrial mutator mice. Exp Gerontol. 2019 10 01; 125:110675. Kim MJ, Haroon S, Chen GD, Ding D, Wanagat J, Liu L, Zhang Y, White K, Park HJ, Han C, Boyd K, Caicedo I, Evans K, Linser PJ, Tanokura M, Prolla T, Salvi R, Vermulst M, Someya S. PMID: 31344454; PMCID: PMC6857812.
    View in: PubMed Mentions: 15 Fields:
    Translation:Animals
  25. Oxygen Consumption Measurements in Caenorhabditis elegans Using the Seahorse XF24. Bio Protoc. 2019 Jul 05; 9(13):e3288. Haroon S, Vermulst M. PMID: 33654802; PMCID: PMC7854111.
    View in: PubMed Mentions: 4
  26. Genome-wide Surveillance of Transcription Errors in Eukaryotic Organisms. J Vis Exp. 2018 09 13; (139). Fritsch C, Gout JP, Vermulst M. PMID: 30272673; PMCID: PMC6235186.
    View in: PubMed Mentions: 6 Fields:
    Translation:AnimalsCells
  27. Mitochondrial DNA Variation Dictates Expressivity and Progression of Nuclear DNA Mutations Causing Cardiomyopathy. Cell Metab. 2019 01 08; 29(1):78-90.e5. McManus MJ, Picard M, Chen HW, De Haas HJ, Potluri P, Leipzig J, Towheed A, Angelin A, Sengupta P, Morrow RM, Kauffman BA, Vermulst M, Narula J, Wallace DC. PMID: 30174309; PMCID: PMC6717513.
    View in: PubMed Mentions: 46 Fields:
    Translation:AnimalsCells
  28. Somatic mutations in neurons during aging and neurodegeneration. Acta Neuropathol. 2018 06; 135(6):811-826. Verheijen BM, Vermulst M, van Leeuwen FW. PMID: 29705908; PMCID: PMC5954077.
    View in: PubMed Mentions: 28 Fields:
    Translation:HumansAnimals
  29. Multiple Molecular Mechanisms Rescue mtDNA Disease in C. elegans. Cell Rep. 2018 03 20; 22(12):3115-3125. Haroon S, Li A, Weinert JL, Fritsch C, Ericson NG, Alexander-Floyd J, Braeckman BP, Haynes CM, Bielas JH, Gidalevitz T, Vermulst M. PMID: 29562168; PMCID: PMC6106782.
    View in: PubMed Mentions: 29 Fields:
    Translation:AnimalsCells
  30. The landscape of transcription errors in eukaryotic cells. Sci Adv. 2017 10; 3(10):e1701484. Gout JF, Li W, Fritsch C, Li A, Haroon S, Singh L, Hua D, Fazelinia H, Smith Z, Seeholzer S, Thomas K, Lynch M, Vermulst M. PMID: 29062891; PMCID: PMC5650487.
    View in: PubMed Mentions: 81 Fields:
    Translation:AnimalsCells
  31. Effects of calorie restriction on the lifespan and healthspan of POLG mitochondrial mutator mice. PLoS One. 2017; 12(2):e0171159. Someya S, Kujoth GC, Kim MJ, Hacker TA, Vermulst M, Weindruch R, Prolla TA. PMID: 28158260; PMCID: PMC5291490.
    View in: PubMed Mentions: 16 Fields:
    Translation:Animals
  32. Linking mitochondrial dynamics to mitochondrial protein quality control. Curr Opin Genet Dev. 2016 06; 38:68-74. Haroon S, Vermulst M. PMID: 27235806.
    View in: PubMed Mentions: 21 Fields:
    Translation:HumansCells
  33. Corrigendum: Transcription errors induce proteotoxic stress and shorten cellular lifespan. Nat Commun. 2015 Oct 14; 6:8738. Vermulst M, Denney AS, Lang MJ, Hung CW, Moore S, Moseley MA, Thompson JW, Madden V, Gauer J, Wolfe KJ, Summers DW, Schleit J, Sutphin GL, Haroon S, Holczbauer A, Caine J, Jorgenson J, Cyr D, Kaeberlein M, Strathern JN, Duncan MC, Erie DA. PMID: 26465398.
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  34. Transcription errors induce proteotoxic stress and shorten cellular lifespan. Nat Commun. 2015 Aug 25; 6:8065. Vermulst M, Denney AS, Lang MJ, Hung CW, Moore S, Moseley MA, Mosely AM, Thompson JW, Thompson WJ, Madden V, Gauer J, Wolfe KJ, Summers DW, Schleit J, Sutphin GL, Haroon S, Holczbauer A, Caine J, Jorgenson J, Cyr D, Kaeberlein M, Strathern JN, Duncan MC, Erie DA. PMID: 26304740; PMCID: PMC4684168.
    View in: PubMed Mentions: 65 Fields:
    Translation:AnimalsCells
  35. Decreased mitochondrial DNA mutagenesis in human colorectal cancer. PLoS Genet. 2012; 8(6):e1002689. Ericson NG, Kulawiec M, Vermulst M, Sheahan K, O'Sullivan J, Salk JJ, Bielas JH. PMID: 22685414; PMCID: PMC3369930.
    View in: PubMed Mentions: 48 Fields:
    Translation:HumansCells
  36. Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutations. Cell. 2010 Apr 16; 141(2):280-9. Chen H, Vermulst M, Wang YE, Chomyn A, Prolla TA, McCaffery JM, Chan DC. PMID: 20403324; PMCID: PMC2876819.
    View in: PubMed Mentions: 655 Fields:
    Translation:AnimalsCells
  37. On mitochondria, mutations, and methodology. Cell Metab. 2009 Dec; 10(6):437. Vermulst M, Wanagat J, Loeb LA. PMID: 19945399.
    View in: PubMed Mentions: 13 Fields:
    Translation:Animals
  38. Overexpression of catalase targeted to mitochondria attenuates murine cardiac aging. Circulation. 2009 Jun 02; 119(21):2789-97. Dai DF, Santana LF, Vermulst M, Tomazela DM, Emond MJ, MacCoss MJ, Gollahon K, Martin GM, Loeb LA, Ladiges WC, Rabinovitch PS. PMID: 19451351; PMCID: PMC2858759.
    View in: PubMed Mentions: 293 Fields:
    Translation:AnimalsCells
  39. Quantification of random mutations in the mitochondrial genome. Methods. 2008 Dec; 46(4):263-8. Vermulst M, Bielas JH, Loeb LA. PMID: 18948200; PMCID: PMC2615251.
    View in: PubMed Mentions: 37 Fields:
    Translation:HumansCells
  40. DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice. Nat Genet. 2008 Apr; 40(4):392-4. Vermulst M, Wanagat J, Kujoth GC, Bielas JH, Rabinovitch PS, Prolla TA, Loeb LA. PMID: 18311139.
    View in: PubMed Mentions: 220 Fields:
    Translation:AnimalsCells
  41. Mitochondrial point mutations do not limit the natural lifespan of mice. Nat Genet. 2007 Apr; 39(4):540-3. Vermulst M, Bielas JH, Kujoth GC, Ladiges WC, Rabinovitch PS, Prolla TA, Loeb LA. PMID: 17334366.
    View in: PubMed Mentions: 221 Fields:
    Translation:AnimalsCells

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