Shaun Hussain • UCLA Profiles (original) (raw)

  1. EEG functional connectivity as a marker of evolution from infantile epileptic spasms syndrome to Lennox-Gastaut syndrome. Epilepsia. 2026 Feb; 67(2):895-907. Romero Milà B, Liu VB, Smith RJ, Hu DK, Benneian NA, Hussain SA, Steenari M, Phillips D, Adams D, Skora C, Lopour BA, Shrey DW. PMID: 41283772; PMCID: PMC12927670.
    View in: PubMed Mentions: 1 Fields:
    Translation:Humans
  2. Treatment Practices for Infantile Epileptic Spasms Syndrome: Consensus and Variation in Major Pediatric Epilepsy Centers. Pediatr Neurol. 2026 Jan; 174:46-53. Briscoe C, Katyayan A, Harini C, Hussain SA, Bhalla S, Singh A, Donatelli S, Sandoval Karamian AG, Samanta D, Sirsi D, Catenaccio E, Planchart Ferretto MA, Thio LL, Hunter SE, Spriha P, Rao CK, Bhatia S, Erdemir G, Shrey DW, Numis AL. PMID: 41172580.
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    Translation:Humans
  3. PyHFO 2.0: an open-source platform for deep learning-based clinical high-frequency oscillations analysis. J Neural Eng. 2025 Oct 27; 22(5). Ding Y, Zhang Y, Duan C, Daida A, Zhang Y, Kanai S, Lu M, Hussain S, Staba RJ, Nariai H, Roychowdhury V. PMID: 41061718; PMCID: PMC12555012.
    View in: PubMed Mentions: 1 Fields:
    Translation:Humans
  4. Optimizing responsive neurostimulation targeting based on interictal high-frequency oscillations and phase-amplitude coupling. Epilepsia. 2026 Feb; 67(2):862-877. Kanai S, Daida A, Zhang Y, Ding Y, Monsoor T, Qiao JX, Salamon N, Ronne E, Ahn SS, Hussain SA, Sankar R, Fallah A, Speier W, Roychowdhury V, Engel J, Staba RJ, Nariai H. PMID: 41105471.
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    Translation:Humans
  5. Self-supervised data-driven approach defines pathological high-frequency oscillations in epilepsy. Epilepsia. 2025 Nov; 66(11):4434-4450. Zhang Y, Daida A, Liu L, Kuroda N, Ding Y, Oana S, Kanai S, Monsoor T, Duan C, Hussain SA, Qiao JX, Salamon N, Fallah A, Sim MS, Sankar R, Staba RJ, Engel J, Asano E, Roychowdhury V, Nariai H. PMID: 40650866; PMCID: PMC12266643.
    View in: PubMed Mentions: 2 Fields:
    Translation:Humans
  6. Electroencephalogram (EEG) Spike Metrics Discriminate Impending Epileptic Spasms From Other Seizures in Children With Tuberous Sclerosis Complex: A Pilot Study. J Child Neurol. 2026 Jan; 41(1):60-67. Brandon Bravo Bruinsma PJ, Hadjinicolaou A, Rajaraman RR, Hussain SA, Krueger DA, Sahin M, Northrup H, Porter BE, Wu JY, Bebin EM, Peters JM, TACERN Study Group. PMID: 40625144.
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    Translation:Humans
  7. Comparative effectiveness of second-line treatments for epileptic spasms. Epilepsia. 2025 Oct; 66(10):3799-3809. Barbour K, Hussain SA, Knupp KG, Berg AT, Chu CJ, Coryell J, Sánchez Fernández I, Gaillard WD, Harini C, Keator CG, Loddenkemper T, Mitchell WG, Mytinger JR, Nordli DR, Patel AD, Shellhaas RA, Singhal NS, Valencia I, Wirrell EC, Wusthoff CJ, Yozawitz EG, Grinspan ZM. PMID: 40528701.
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    Translation:Humans
  8. Evidence of thalamocortical network activation during epileptic spasms: A thalamic stereotactic EEG study. Epilepsia. 2025 Jul; 66(7):2407-2420. Daida A, Panchavati S, Oana S, Kanai S, Zhang Y, Ding Y, Rajsekar RR, Salamon N, Sankar R, Fallah A, Hussain SA, Roychowdhury V, Speier W, Nariai H. PMID: 40053323.
    View in: PubMed Mentions: 2 Fields:
    Translation:Humans
  9. Discovering EEG biomarkers of Lennox-Gastaut syndrome through unsupervised time-frequency analysis. Epilepsia. 2025 Feb; 66(2):541-553. Hu DK, Pinto-Orellana MA, Rana M, Do L, Adams DJ, Hussain SA, Shrey DW, Lopour BA. PMID: 39666270; PMCID: PMC11827736.
    View in: PubMed Mentions: 1 Fields:
    Translation:Humans
  10. Symptomatic vigabatrin-associated MRI toxicity is associated with simultaneous hormonal therapy among patients with infantile spasms. Epilepsia Open. 2025 Feb; 10(1):314-320. Sathe R, Shrestha G, Terango A, Tabibzadeh D, Rajaraman RR, Nariai H, Hussain SA. PMID: 39570186; PMCID: PMC11803263.
    View in: PubMed Mentions: 1 Fields:
    Translation:Humans
  11. Self-Supervised Data-Driven Approach Defines Pathological High-Frequency Oscillations in Human. medRxiv. 2024 Nov 05. Zhang Y, Daida A, Liu L, Kuroda N, Ding Y, Oana S, Kanai S, Monsoor T, Duan C, Hussain SA, Qiao JX, Salamon N, Fallah A, Sim MS, Sankar R, Staba RJ, Engel J, Asano E, Roychowdhury V, Nariai H. PMID: 39040207; PMCID: PMC11261948.
    View in: PubMed Mentions: 1
  12. Multi-disciplinary team approach for pediatric hemimegalencephaly: Insights from a single institutional case series. Epilepsia Open. 2024 Dec; 9(6):2510-2517. Edmonds B, Ngo JP, Groves A, Reyes B, Gott RA, Chia DJ, Mirbaha H, Magaki S, Khanlou N, Pineles SL, Salamon N, Thompson RM, Newman M, Rajaraman RR, Hussain SA, Fallah A, Russell B, Nariai H. PMID: 39442533; PMCID: PMC11633684.
    View in: PubMed Mentions: 2 Fields:
    Translation:Humans
  13. Lentiviral Gene Therapy for Cerebral Adrenoleukodystrophy. N Engl J Med. 2024 10 10; 391(14):1302-1312. Eichler F, Duncan CN, Musolino PL, Lund TC, Gupta AO, De Oliveira S, Thrasher AJ, Aubourg P, Kühl JS, Loes DJ, Amartino H, Smith N, Folloni Fernandes J, Sevin C, Sankar R, Hussain SA, Gissen P, Dalle JH, Platzbecker U, Downey GF, McNeil E, Demopoulos L, Dietz AC, Thakar HL, Orchard PJ, Williams DA. PMID: 39383459; PMCID: PMC12465018.
    View in: PubMed Mentions: 22 Fields:
    Translation:HumansCellsCTClinical Trials
  14. Overnight Electroencephalogram to Forecast Epilepsy Development in Children with Autism Spectrum Disorders. J Pediatr. 2024 11; 274:114217. Daida A, Oana S, Nadkarni D, Espiritu BL, Edmonds BD, Stanecki C, Samuel AS, Rao LM, Rajaraman RR, Hussain SA, Matsumoto JH, Sankar R, Hannauer PS, Nariai H. PMID: 39074735.
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    Translation:Humans
  15. Bilateral centromedian nucleus of thalamus responsive neurostimulation for pediatric-onset drug-resistant epilepsy. Epilepsia. 2024 Aug; 65(8):e131-e140. Ahn S, Edmonds B, Rajaraman RR, Rao LM, Hussain SA, Matsumoto JH, Sankar R, Salamon N, Fallah A, Nariai H. PMID: 38845459; PMCID: PMC11315622.
    View in: PubMed Mentions: 6 Fields:
    Translation:Humans
  16. PyHFO: lightweight deep learning-powered end-to-end high-frequency oscillations analysis application. J Neural Eng. 2024 05 28; 21(3). Zhang Y, Liu L, Ding Y, Chen X, Monsoor T, Daida A, Oana S, Hussain S, Sankar R, Fallah A, Santana-Gomez C, Engel J, Staba RJ, Speier W, Zhang J, Nariai H, Roychowdhury V. PMID: 38722308; PMCID: PMC11135143.
    View in: PubMed Mentions: 5 Fields:
    Translation:HumansAnimals
  17. Computational EEG attributes predict response to therapy for epileptic spasms. Clin Neurophysiol. 2024 07; 163:39-46. Rajaraman RR, Smith RJ, Oana S, Daida A, Shrey DW, Nariai H, Lopour BA, Hussain SA. PMID: 38703698; PMCID: PMC12525723.
    View in: PubMed Mentions: 3 Fields:
    Translation:Humans
  18. Epileptic spasms relapse is associated with response latency but not conventional attributes of post-treatment EEG. Epilepsia Open. 2024 Jun; 9(3):1034-1041. Deckard E, Sathe R, Tabibzadeh D, Terango A, Groves A, Rajaraman RR, Nariai H, Hussain SA. PMID: 38588009; PMCID: PMC11145600.
    View in: PubMed Mentions: 3 Fields:
  19. Optimizing detection and deep learning-based classification of pathological high-frequency oscillations in epilepsy. Clin Neurophysiol. 2023 10; 154:129-140. Monsoor T, Zhang Y, Daida A, Oana S, Lu Q, Hussain SA, Fallah A, Sankar R, Staba RJ, Speier W, Roychowdhury V, Nariai H. PMID: 37603979; PMCID: PMC10861270.
    View in: PubMed Mentions: 5 Fields:
    Translation:Humans
  20. Characterizing physiological high-frequency oscillations using deep learning. J Neural Eng. 2022 12 07; 19(6). Zhang Y, Chung H, Ngo JP, Monsoor T, Hussain SA, Matsumoto JH, Walshaw PD, Fallah A, Sim MS, Asano E, Sankar R, Staba RJ, Engel J, Speier W, Roychowdhury V, Nariai H. PMID: 36541546; PMCID: PMC10364130.
    View in: PubMed Mentions: 10 Fields:
    Translation:Humans
  21. Association of Time to Clinical Remission With Sustained Resolution in Children With New-Onset Infantile Spasms. Neurology. 2022 11 29; 99(22):e2494-e2503. Yuskaitis CJ, Mytinger JR, Baumer FM, Zhang B, Liu S, Samanta D, Hussain SA, Yozawitz EG, Keator CG, Joshi C, Singh RK, Bhatia S, Bhalla S, Shellhaas R, Harini C, Pediatric Epilepsy Research Consortium. PMID: 36038267; PMCID: PMC9728034.
    View in: PubMed Mentions: 9 Fields:
    Translation:Humans
  22. Real-World Preliminary Experience With Responsive Neurostimulation in Pediatric Epilepsy: A Multicenter Retrospective Observational Study. Neurosurgery. 2021 11 18; 89(6):997-1004. Nagahama Y, Zervos TM, Murata KK, Holman L, Karsonovich T, Parker JJ, Chen JS, Phillips HW, Fajardo M, Nariai H, Hussain SA, Porter BE, Grant GA, Ragheb J, Wang S, O'Neill BR, Alexander AL, Bollo RJ, Fallah A. PMID: 34528103; PMCID: PMC8637802.
    View in: PubMed Mentions: 14 Fields:
    Translation:Humans
  23. Refining epileptogenic high-frequency oscillations using deep learning: a reverse engineering approach. Brain Commun. 2022; 4(1):fcab267. Zhang Y, Lu Q, Monsoor T, Hussain SA, Qiao JX, Salamon N, Fallah A, Sim MS, Asano E, Sankar R, Staba RJ, Engel J, Speier W, Roychowdhury V, Nariai H. PMID: 35169696; PMCID: PMC8833577.
    View in: PubMed Mentions: 17
  24. Comparative Effectiveness of Initial Treatment for Infantile Spasms in a Contemporary US Cohort. Neurology. 2021 Sep 20; 97(12):e1217-e1228. Grinspan ZM, Knupp KG, Patel AD, Yozawitz EG, Wusthoff CJ, Wirrell EC, Valencia I, Singhal NS, Nordli DR, Mytinger JR, Mitchell WG, Keator CG, Loddenkemper T, Hussain SA, Harini C, Gaillard WD, Fernandez IS, Coryell J, Chu CJ, Berg AT, Shellhaas RA. PMID: 34266919; PMCID: PMC8480478.
    View in: PubMed Mentions: 13 Fields:
  25. Abnormal sleep physiology in children with 15q11.2-13.1 duplication (Dup15q) syndrome. Mol Autism. 2021 08 03; 12(1):54. Saravanapandian V, Nadkarni D, Hsu SH, Hussain SA, Maski K, Golshani P, Colwell CS, Balasubramanian S, Dixon A, Geschwind DH, Jeste SS. PMID: 34344470; PMCID: PMC8336244.
    View in: PubMed Mentions: 15 Fields:
    Translation:Humans
  26. Potential induction of epileptic spasms by nonselective voltage-gated sodium channel blockade: Interaction with etiology. Epilepsy Behav. 2021 02; 115:107624. Hussain SA, Heesch J, Weng J, Rajaraman RR, Numis AL, Sankar R. PMID: 33341392.
    View in: PubMed Mentions: 4 Fields:
    Translation:Humans
  27. Scalp EEG interictal high frequency oscillations as an objective biomarker of infantile spasms. Clin Neurophysiol. 2020 11; 131(11):2527-2536. Nariai H, Hussain SA, Bernardo D, Motoi H, Sonoda M, Kuroda N, Asano E, Nguyen JC, Elashoff D, Sankar R, Bragin A, Staba RJ, Wu JY. PMID: 32927206; PMCID: PMC7606823.
    View in: PubMed Mentions: 19 Fields:
    Translation:Humans
  28. Felbamate in the treatment of refractory epileptic spasms. Epilepsy Res. 2020 03; 161:106284. Hussain SA, Asilnejad B, Heesch J, Navarro M, Ji M, Shrey DW, Rajaraman RR, Sankar R. PMID: 32058261.
    View in: PubMed Mentions: 3 Fields:
    Translation:Humans
  29. Limited efficacy of zonisamide in the treatment of refractory infantile spasms. Epilepsia Open. 2020 Mar; 5(1):121-126. Hussain SA, Navarro M, Heesch J, Ji M, Asilnejad B, Peters H, Rajaraman RR, Sankar R. PMID: 32140650; PMCID: PMC7049796.
    View in: PubMed Mentions: 3 Fields:
  30. The economic burden of caregiving in epilepsy: An estimate based on a survey of US caregivers. Epilepsia. 2020 02; 61(2):319-329. Hussain SA, Ortendahl JD, Bentley TGK, Harmon AL, Gupta S, Begley CE, Khilfeh I, Knoth RL. PMID: 31953846.
    View in: PubMed Mentions: 18 Fields:
    Translation:Humans
  31. Synthetic pharmaceutical grade cannabidiol for treatment of refractory infantile spasms: A multicenter phase-2 study. Epilepsy Behav. 2020 01; 102:106826. Hussain SA, Dlugos DJ, Cilio MR, Parikh N, Oh A, Sankar R. PMID: 31816477.
    View in: PubMed Mentions: 10 Fields:
    Translation:HumansCTClinical Trials
  32. Prospective observational study: Fast ripple localization delineates the epileptogenic zone. Clin Neurophysiol. 2019 11; 130(11):2144-2152. Nariai H, Hussain SA, Bernardo D, Fallah A, Murata KK, Nguyen JC, Rajaraman RR, Rao LM, Matsumoto JH, Lerner JT, Salamon N, Elashoff D, Sankar R, Wu JY. PMID: 31569042.
    View in: PubMed Mentions: 17 Fields:
    Translation:Humans
  33. The equivalence of the ketogenic diet and adrenocorticotropic hormone for treatment of infantile spasms: More suggestion than conclusion. Epilepsia. 2019 10; 60(10):2145. Hussain SA. PMID: 31460668.
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    Translation:Humans
  34. Very-High-Dose Prednisolone Before ACTH for Treatment of Infantile Spasms: Evaluation of a Standardized Protocol. Pediatr Neurol. 2019 10; 99:16-22. Eliyan Y, Heesch J, Alayari A, Rajaraman RR, Sankar R, Hussain SA. PMID: 31331669.
    View in: PubMed Mentions: 8 Fields:
    Translation:Humans
  35. Hypsarrhythmia is associated with widespread, asymmetric cerebral hypermetabolism. Seizure. 2019 Oct; 71:29-34. Weng JK, Ahn R, Hussain SA. PMID: 31202190.
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    Translation:Humans
  36. Interrater reliability in visual identification of interictal high-frequency oscillations on electrocorticography and scalp EEG. Epilepsia Open. 2018 Dec; 3(Suppl Suppl 2):127-132. Nariai H, Wu JY, Bernardo D, Fallah A, Sankar R, Hussain SA. PMID: 30564771; PMCID: PMC6293061.
    View in: PubMed Mentions: 15 Fields:
  37. Treatment of infantile spasms. Epilepsia Open. 2018 Dec; 3(Suppl Suppl 2):143-154. Hussain SA. PMID: 30564773; PMCID: PMC6293071.
    View in: PubMed Mentions: 21 Fields:
  38. A comparison of levetiracetam and phenobarbital for the treatment of neonatal seizures associated with hypoxic-ischemic encephalopathy. Epilepsy Behav. 2018 11; 88:212-217. Rao LM, Hussain SA, Zaki T, Cho A, Chanlaw T, Garg M, Sankar R. PMID: 30296665.
    View in: PubMed Mentions: 16 Fields:
    Translation:Humans
  39. High vigabatrin dosage is associated with lower risk of infantile spasms relapse among children with tuberous sclerosis complex. Epilepsy Res. 2018 12; 148:1-7. Hussain SA, Schmid E, Peters JM, Goyal M, Bebin EM, Northrup H, Sahin M, Krueger DA, Wu JY, Tuberous Sclerosis Complex Autism Center of Excellence Network. PMID: 30296632; PMCID: PMC6347124.
    View in: PubMed Mentions: 14 Fields:
    Translation:Humans
  40. Successful use of pure cannabidiol for the treatment of super-refractory status epilepticus. Epilepsy Behav Case Rep. 2018; 10:141-144. Rajaraman RR, Sankar R, Hussain SA. PMID: 30596011; PMCID: PMC6306515.
    View in: PubMed Mentions: 2
  41. Amantadine: A new treatment for refractory electrical status epilepticus in sleep. Epilepsy Behav. 2018 07; 84:74-78. Wilson RB, Eliyan Y, Sankar R, Hussain SA. PMID: 29754107.
    View in: PubMed Mentions: 8 Fields:
    Translation:Humans
  42. Visual and semi-automatic non-invasive detection of interictal fast ripples: A potential biomarker of epilepsy in children with tuberous sclerosis complex. Clin Neurophysiol. 2018 07; 129(7):1458-1466. Bernardo D, Nariai H, Hussain SA, Sankar R, Salamon N, Krueger DA, Sahin M, Northrup H, Bebin EM, Wu JY, UCLA Pediatric Epilepsy Group, TACERN Study Group. PMID: 29673547.
    View in: PubMed Mentions: 27 Fields:
    Translation:Humans
  43. Reply. J Pediatr. 2018 06; 197:319. Hussain SA. PMID: 29550223.
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    Translation:Humans
  44. Recognition of Infantile Spasms Is Often Delayed: The ASSIST Study. J Pediatr. 2017 11; 190:215-221.e1. Hussain SA, Lay J, Cheng E, Weng J, Sankar R, Baca CB. PMID: 29144248.
    View in: PubMed Mentions: 27 Fields:
    Translation:Humans
  45. Intraoperative fast ripples independently predict postsurgical epilepsy outcome: Comparison with other electrocorticographic phenomena. Epilepsy Res. 2017 09; 135:79-86. Hussain SA, Mathern GW, Hung P, Weng J, Sankar R, Wu JY. PMID: 28644979; PMCID: PMC5568451.
    View in: PubMed Mentions: 22 Fields:
    Translation:Humans
  46. Risk of vigabatrin-associated brain abnormalities on MRI in the treatment of infantile spasms is dose-dependent. Epilepsia. 2017 04; 58(4):674-682. Hussain SA, Tsao J, Li M, Schwarz MD, Zhou R, Wu JY, Salamon N, Sankar R. PMID: 28230253.
    View in: PubMed Mentions: 19 Fields:
    Translation:Humans
  47. Conductive Plastic Electrodes Reduce EEG Artifact During Pediatric ECMO Therapy. J Clin Neurophysiol. 2016 Oct; 33(5):426-430. Matsumoto JH, McArthur DL, Szeliga CW, Lerner JT, Rao LM, Hussain SA, Wu JY, Nuwer MR, Sankar R. PMID: 26886103.
    View in: PubMed Mentions: 2 Fields:
    Translation:Humans
  48. Prospective and "live" fast ripple detection and localization in the operating room: Impact on epilepsy surgery outcomes in children. Epilepsy Res. 2016 11; 127:344-351. Hussain SA, Mathern GW, Sankar R, Wu JY. PMID: 27721161.
    View in: PubMed Mentions: 14 Fields:
    Translation:Humans
  49. Prevention of infantile spasms relapse: Zonisamide and topiramate provide no benefit. Epilepsia. 2016 08; 57(8):1280-7. Rajaraman RR, Lay J, Alayari A, Anderson K, Sankar R, Hussain SA. PMID: 27312124.
    View in: PubMed Mentions: 8 Fields:
    Translation:Humans
  50. A lack of clinically apparent vision loss among patients treated with vigabatrin with infantile spasms: The UCLA experience. Epilepsy Behav. 2016 Apr; 57(Pt A):29-33. Schwarz MD, Li M, Tsao J, Zhou R, Wu YW, Sankar R, Wu JY, Hussain SA. PMID: 26921595.
    View in: PubMed Mentions: 9 Fields:
    Translation:Humans
  51. A randomized placebo-controlled lovastatin trial for neurobehavioral function in neurofibromatosis I. Ann Clin Transl Neurol. 2016 04; 3(4):266-79. Bearden CE, Hellemann GS, Rosser T, Montojo C, Jonas R, Enrique N, Pacheco L, Hussain SA, Wu JY, Ho JS, McGough JJ, Sugar CA, Silva AJ. PMID: 27081657; PMCID: PMC4818747.
    View in: PubMed Mentions: 32 Fields:
  52. Limited efficacy of the ketogenic diet in the treatment of highly refractory epileptic spasms. Seizure. 2016 Feb; 35:59-64. Hussain SA, Shin JH, Shih EJ, Murata KK, Sewak S, Kezele ME, Sankar R, Matsumoto JH. PMID: 26803052.
    View in: PubMed Mentions: 4 Fields:
    Translation:Humans
  53. Improving the inter-rater agreement of hypsarrhythmia using a simplified EEG grading scale for children with infantile spasms. Epilepsy Res. 2015 Oct; 116:93-8. Mytinger JR, Hussain SA, Islam MP, Millichap JJ, Patel AD, Ryan NR, Twanow JD, Heyer GL. PMID: 26280806.
    View in: PubMed Mentions: 28 Fields:
    Translation:Humans
  54. Perceived efficacy of cannabidiol-enriched cannabis extracts for treatment of pediatric epilepsy: A potential role for infantile spasms and Lennox-Gastaut syndrome. Epilepsy Behav. 2015 Jun; 47:138-41. Hussain SA, Zhou R, Jacobson C, Weng J, Cheng E, Lay J, Hung P, Lerner JT, Sankar R. PMID: 25935511.
    View in: PubMed Mentions: 71 Fields:
    Translation:HumansAnimals
  55. Hypsarrhythmia assessment exhibits poor interrater reliability: a threat to clinical trial validity. Epilepsia. 2015 Jan; 56(1):77-81. Hussain SA, Kwong G, Millichap JJ, Mytinger JR, Ryan N, Matsumoto JH, Wu JY, Lerner JT, Sankar R. PMID: 25385396.
    View in: PubMed Mentions: 34 Fields:
    Translation:Humans
  56. Treatment of infantile spasms with very high dose prednisolone before high dose adrenocorticotropic hormone. Epilepsia. 2014 Jan; 55(1):103-7. Hussain SA, Shinnar S, Kwong G, Lerner JT, Matsumoto JH, Wu JY, Shields WD, Sankar R. PMID: 24446954; PMCID: PMC3904676.
    View in: PubMed Mentions: 20 Fields:
    Translation:HumansCTClinical Trials
  57. Pharmacologic treatment of intractable epilepsy in children: a syndrome-based approach. Semin Pediatr Neurol. 2011 Sep; 18(3):171-8. Hussain S, Sankar R. PMID: 22062941.
    View in: PubMed Mentions: 3 Fields:
    Translation:Humans

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