Cynthia Hsu • UCSD Profiles (original) (raw)

  1. Macrophage-derived cathepsin B disrupts intestinal tight junctions through occludin degradation and promotes alcohol-associated liver disease. J Hepatol. 2026 Feb 05. Fondevila MF, Kreimeyer H, Hsu CL, Tamargo-Azpilicueta J, Day LZ, Gritsenko M, Attah K, Cabré N, Harberts A, Tonetti FR, Yang Y, Yamazaki T, Schöler D, Eguileor A, Blasio C, Meijnikman AS, Zhang X, Garcia-Carbonell R, Hook V, Zhou E, Sun Z, Jacobs JM, Turner JR, Llorente C, AlcHepNet Investigators, Glass CK, Stärkel P, Reinheckel T, Diaz-Moreno I, Gonzalez DJ, Schnabl B. PMID: 41654223.
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  2. Gut microbial ethanol metabolism contributes to auto-brewery syndrome in an observational cohort. Nat Microbiol. 2026 Feb; 11(2):415-428. Hsu CL, Shukla S, Freund L, Chou AC, Yang Y, Bruellman R, Raya Tonetti F, Cabré N, Mayo S, Lim HG, Magallan V, Cordell BJ, Lang S, Demir M, Stärkel P, Llorente C, Palsson BO, Mandyam C, Boland BS, Hohmann E, Schnabl B. PMID: 41507585.
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  3. Single-Nuclei RNA Sequencing Shows the Engagement of PPAR-Delta Target Genes Primarily in Hepatocytes and Cholangiocytes by the Selective PPAR-Delta Agonist Seladelpar. PPAR Res. 2025; 2025:2935230. Yamazaki T, Yang Y, Schöler D, Yukawa-Muto Y, Kouno T, Harberts A, Sakane S, Freund L, Hsu CL, Whisenant TC, Rosenthal SB, Kisseleva T, Cable EE, Schnabl B. PMID: 41180305; PMCID: PMC12575037.
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  4. Retatrutide improves steatohepatitis in an accelerated mouse model of diet-induced steatohepatitis with a fructose binge. Am J Physiol Gastrointest Liver Physiol. 2025 Dec 01; 329(6):G680-G695. Viebahn GK, Khurana A, Freund L, Chilin-Fuentes D, Jepsen K, Rosenthal SB, Chatterjee S, Ellenrieder V, Hsu CL, Schnabl B, Hartmann P. PMID: 41056349; PMCID: PMC12643026.
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  5. Clinical trial design, biomarkers and end points in metabolic and alcohol-related liver disease. Nat Rev Gastroenterol Hepatol. 2025 Dec; 22(12):866-884. Diaz LA, Thiele M, Louvet A, Lee BP, Ajmera V, Tavaglione F, Hsu CL, Huang DQ, Pose E, Bataller R, McClain C, Mellinger J, Tincopa M, Mitchell MC, Ratziu V, Rinella ME, Sarin SK, Shah VH, Szabo G, Wong VW, Bansal MB, Leggio L, Kamath PS, Krag A, Sanyal AJ, Arrese M, Arab JP, Anstee QM, Mathurin P, Loomba R. PMID: 41006824.
    View in: PubMed Mentions: 1 Fields:
    Translation:Humans
  6. mAChR4 suppresses liver disease via GAP-induced antimicrobial immunity. Nature. 2025 Oct; 646(8083):180-189. Llorente C, Raya Tonetti F, Bruellman R, Brea R, Pell N, Hartmann P, Maccioni L, Han H, Cabré N, Liu J, Eguileor A, Fondevila MF, Meijnikman AS, Hsu CL, Alghafri A, Zhou R, Gao B, Duan Y, Zhang P, Febbraio MA, Taniguchi K, Newberry RD, Fouts DE, Brenner DA, Stärkel P, Karin M, Schnabl B. PMID: 40836099; PMCID: PMC12991828.
    View in: PubMed Mentions: Fields:
  7. Sleep drive, not total sleep amount, increases seizure risk. Nat Commun. 2025 Jul 29; 16(1):6967. Cuddapah VA, Hsu CT, Valle Sirias F, Li Y, Shah HM, Saul C, Killiany S, Guevara C, Shon J, Yue Z, Gionet GL, Putt ME, Sehgal A. PMID: 40730814; PMCID: PMC12307685.
    View in: PubMed Mentions: Fields:
    Translation:Animals
  8. Clock-dependent regulation of a homeostatic sleep center maintains daytime sleep and evening activity. Curr Biol. 2025 Jul 21; 35(14):3496-3506.e5. Hsu CT, Guevara C, Killiany SL, Shon J, Dissel S, Sehgal A. PMID: 40580958; PMCID: PMC12316106.
    View in: PubMed Mentions: 2 Fields:
    Translation:AnimalsCells
  9. An Expert Consensus Delphi Panel in Metabolic Dysfunction- and Alcohol-associated Liver Disease: Opportunities and Challenges in Clinical Practice. Clin Gastroenterol Hepatol. 2026 Mar; 24(3):633-645.e4. Diaz LA, Ajmera V, Arab JP, Huang DQ, Hsu C, Lee BP, Louvet A, Thiele M, Tavaglione F, Tincopa M, Pose E, Adams LA, Alazawi W, Arrese M, Bataller R, Duseja A, Liangpunsakul S, Lucey MR, Mathurin P, Mellinger J, Nakajima A, Ratziu V, Reau N, Rinella ME, Thursz M, Wong VW, Kamath PS, Loomba R. PMID: 40315973.
    View in: PubMed Mentions: 3 Fields:
    Translation:Humans
  10. Alcohol Use Disorder and the Gut-Brain Axis: A Narrative Review of the Role of Gut Microbiota and Implications for Treatment. Microorganisms. 2025 Jan 02; 13(1). Shukla S, Hsu CL. PMID: 39858835; PMCID: PMC11767426.
    View in: PubMed Mentions: 7
  11. Faecal proteomics links neutrophil degranulation with mortality in patients with alcohol-associated hepatitis. Gut. 2024 Dec 10; 74(1):103-115. Kreimeyer H, Gonzalez CG, Fondevila MF, Hsu CL, Hartmann P, Zhang X, Stärkel P, Bosques-Padilla F, Verna EC, Abraldes JG, Brown RS, Vargas V, Altamirano J, Caballería J, Shawcross DL, Louvet A, Lucey MR, Mathurin P, Garcia-Tsao G, Bataller R, Investigators A, Gonzalez DJ, Schnabl B. PMID: 39033024; PMCID: PMC11631684.
    View in: PubMed Mentions: 3 Fields:
    Translation:HumansCells
  12. Viral antibody response predicts morbidity and mortality in alcohol-associated hepatitis. Hepatology. 2025 Jul 01; 82(1):127-139. Hsu CL, Wang L, Maestri E, Jacob AR, Do WL, Mayo S, Bosques-Padilla F, Verna EC, Abraldes JG, Brown RS, Vargas V, Altamirano J, Caballería J, Shawcross DL, Louvet A, Lucey MR, Mathurin P, Garcia-Tsao G, Stärkel P, Bataller R, Investigators A, Wang XW, Schnabl B. PMID: 39325984; PMCID: PMC11932942.
    View in: PubMed Mentions: Fields:
    Translation:Humans
  13. Early detection of liver disease in patients with alcohol use disorder improves long-term abstinence. Alcohol Alcohol. 2024 Sep 21; 59(6). Orgill A, Jew MH, Soltani M, Deioma A, Grant M, Patton HM, Hsu CL. PMID: 39492699; PMCID: PMC11532622.
    View in: PubMed Mentions: 2 Fields:
    Translation:Humans
  14. Evidence for a role of human blood-borne factors in mediating age-associated changes in molecular circadian rhythms. bioRxiv. 2024 Jul 01. Schwarz JE, Mrcela A, Lahens NF, Li Y, Hsu CT, Grant G, Skarke C, Zhang SL, Sehgal A. PMID: 37808824; PMCID: PMC10557775.
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  15. From NAFLD to MASLD: implications of the new nomenclature for preclinical and clinical research. Nat Metab. 2024 Apr; 6(4):600-602. Hsu CL, Loomba R. PMID: 38383845; PMCID: PMC11262457.
    View in: PubMed Mentions: 34 Fields:
    Translation:HumansAnimals
  16. Serum aryl hydrocarbon receptor activity is associated with survival in patients with alcohol-associated hepatitis. Hepatology. 2024 08 01; 80(2):403-417. Yamazaki T, Kouno T, Hsu CL, Hartmann P, Mayo S, Zhang X, Stärkel P, Bosques-Padilla F, Verna EC, Abraldes JG, Brown RS, Vargas V, Altamirano J, Caballería J, Shawcross DL, Louvet A, Lucey MR, Mathurin P, Garcia-Tsao G, Bataller R, Schnabl B, AlcHepNet Investigators. PMID: 38377466; PMCID: PMC11268475.
    View in: PubMed Mentions: 3 Fields:
    Translation:HumansCells
  17. The gut-liver axis and gut microbiota in health and liver disease. Nat Rev Microbiol. 2023 11; 21(11):719-733. Hsu CL, Schnabl B. PMID: 37316582; PMCID: PMC10794111.
    View in: PubMed Mentions: 235 Fields:
    Translation:Humans
  18. MAP4K3 inhibits Sirtuin-1 to repress the LKB1-AMPK pathway to promote amino acid-dependent activation of the mTORC1 complex. Life Sci Alliance. 2023 08; 6(8). Branch MR, Hsu CL, Ohnishi K, Shen WC, Lee E, Meisenhelder J, Winborn B, Sopher BL, Taylor JP, Hunter T, La Spada AR. PMID: 37221017; PMCID: PMC10205607.
    View in: PubMed Mentions: 2 Fields:
    Translation:Cells
  19. Alcohol, the gut microbiome, and liver disease. J Gastroenterol Hepatol. 2023 Aug; 38(8):1205-1210. Jew MH, Hsu CL. PMID: 37096652; PMCID: PMC11272486.
    View in: PubMed Mentions: 26 Fields:
    Translation:Humans
  20. Chronic sleep loss sensitizes Drosophila melanogaster to nitrogen stress. Curr Biol. 2023 04 24; 33(8):1613-1623.e5. Bedont JL, Kolesnik A, Pivarshev P, Malik D, Hsu CT, Weljie A, Sehgal A. PMID: 36965479; PMCID: PMC10133188.
    View in: PubMed Mentions: 11 Fields:
    Translation:Animals
  21. Differences in Bacterial Translocation and Liver Injury in Ethanol Versus Diet-Induced Liver Disease. Dig Dis Sci. 2023 07; 68(7):3059-3069. Hsu CL, Wang Y, Duan Y, Chu H, Hartmann P, Llorente C, Zhou R, Schnabl B. PMID: 36807831; PMCID: PMC10313731.
    View in: PubMed Mentions: 14 Fields:
    Translation:AnimalsCells
  22. Any alcohol use in NAFLD patients is associated with significant changes to the intestinal virome. Hepatology. 2023 06 01; 77(6):2073-2083. Hsu CL, Lang S, Demir M, Fouts DE, Stärkel P, Schnabl B. PMID: 36631002; PMCID: PMC10192041.
    View in: PubMed Mentions: 15 Fields:
    Translation:Humans
  23. Intestinal virome in patients with alcohol use disorder and after abstinence. Hepatol Commun. 2022 08; 6(8):2058-2069. Hsu CL, Zhang X, Jiang L, Lang S, Hartmann P, Pride D, Fouts DE, Stärkel P, Schnabl B. PMID: 35368152; PMCID: PMC9315129.
    View in: PubMed Mentions: 25 Fields:
    Translation:HumansCells
  24. Intestinal virome and therapeutic potential of bacteriophages in liver disease. J Hepatol. 2021 12; 75(6):1465-1475. Hsu CL, Duan Y, Fouts DE, Schnabl B. PMID: 34437908; PMCID: PMC8929164.
    View in: PubMed Mentions: 38 Fields:
    Translation:HumansCells
  25. Serum metabolites detect the presence of advanced fibrosis in derivation and validation cohorts of patients with non-alcoholic fatty liver disease. Gut. 2019 10; 68(10):1884-1892. Caussy C, Ajmera VH, Puri P, Hsu CL, Bassirian S, Mgdsyan M, Singh S, Faulkner C, Valasek MA, Rizo E, Richards L, Brenner DA, Sirlin CB, Sanyal AJ, Loomba R. PMID: 30567742; PMCID: PMC8328048.
    View in: PubMed Mentions: 39 Fields:
    Translation:Humans
  26. Serum bile acid patterns are associated with the presence of NAFLD in twins, and dose-dependent changes with increase in fibrosis stage in patients with biopsy-proven NAFLD. Aliment Pharmacol Ther. 2019 01; 49(2):183-193. Caussy C, Hsu C, Singh S, Bassirian S, Kolar J, Faulkner C, Sinha N, Bettencourt R, Gara N, Valasek MA, Schnabl B, Richards L, Brenner DA, Hofmann AF, Loomba R. PMID: 30506692; PMCID: PMC6319963.
    View in: PubMed Mentions: 64 Fields:
    Translation:Humans
  27. Food anticipatory activity on a calorie-restricted diet is independent of Sirt1. PLoS One. 2018; 13(6):e0199586. Assali DR, Hsu CT, Gunapala KM, Aguayo A, McBurney M, Steele AD. PMID: 29940007; PMCID: PMC6016907.
    View in: PubMed Mentions: 2 Fields:
    Translation:AnimalsCells
  28. Magnetic Resonance vs Transient Elastography Analysis of Patients With Nonalcoholic Fatty Liver Disease: A Systematic Review and Pooled Analysis of Individual Participants. Clin Gastroenterol Hepatol. 2019 Mar; 17(4):630-637.e8. Hsu C, Caussy C, Imajo K, Chen J, Singh S, Kaulback K, Le MD, Hooker J, Tu X, Bettencourt R, Yin M, Sirlin CB, Ehman RL, Nakajima A, Loomba R. PMID: 29908362; PMCID: PMC6294709.
    View in: PubMed Mentions: 195 Fields:
    Translation:Humans
  29. Link between gut-microbiome derived metabolite and shared gene-effects with hepatic steatosis and fibrosis in NAFLD. Hepatology. 2018 09; 68(3):918-932. Caussy C, Hsu C, Lo MT, Liu A, Bettencourt R, Ajmera VH, Bassirian S, Hooker J, Sy E, Richards L, Schork N, Schnabl B, Brenner DA, Sirlin CB, Chen CH, Loomba R, Genetics of NAFLD in Twins Consortium. PMID: 29572891; PMCID: PMC6151296.
    View in: PubMed Mentions: 111 Fields:
    Translation:Humans
  30. A Conserved Circadian Function for the Neurofibromatosis 1 Gene. Cell Rep. 2018 03 27; 22(13):3416-3426. Bai L, Lee Y, Hsu CT, Williams JA, Cavanaugh D, Zheng X, Stein C, Haynes P, Wang H, Gutmann DH, Sehgal A. PMID: 29590612; PMCID: PMC5898822.
    View in: PubMed Mentions: 35 Fields:
    Translation:AnimalsCells
  31. MAP4K3 mediates amino acid-dependent regulation of autophagy via phosphorylation of TFEB. Nat Commun. 2018 03 05; 9(1):942. Hsu CL, Lee EX, Gordon KL, Paz EA, Shen WC, Ohnishi K, Meisenhelder J, Hunter T, La Spada AR. PMID: 29507340; PMCID: PMC5838220.
    View in: PubMed Mentions: 62 Fields:
    Translation:HumansCells
  32. PPARδ activation by bexarotene promotes neuroprotection by restoring bioenergetic and quality control homeostasis. Sci Transl Med. 2017 Dec 06; 9(419). Dickey AS, Sanchez DN, Arreola M, Sampat KR, Fan W, Arbez N, Akimov S, Van Kanegan MJ, Ohnishi K, Gilmore-Hall SK, Flores AL, Nguyen JM, Lomas N, Hsu CL, Lo DC, Ross CA, Masliah E, Evans RM, La Spada AR. PMID: 29212711; PMCID: PMC5748332.
    View in: PubMed Mentions: 30 Fields:
    Translation:HumansAnimalsCells
  33. Organization of descending neurons in Drosophila melanogaster. Sci Rep. 2016 Feb 03; 6:20259. Hsu CT, Bhandawat V. PMID: 26837716; PMCID: PMC4738306.
    View in: PubMed Mentions: 55 Fields:
    Translation:AnimalsCells
  34. Let-7 coordinately suppresses components of the amino acid sensing pathway to repress mTORC1 and induce autophagy. Cell Metab. 2014 Oct 07; 20(4):626-38. Dubinsky AN, Dastidar SG, Hsu CL, Zahra R, Djakovic SN, Duarte S, Esau CC, Spencer B, Ashe TD, Fischer KM, MacKenna DA, Sopher BL, Masliah E, Gaasterland T, Chau BN, Pereira de Almeida L, Morrison BE, La Spada AR. PMID: 25295787; PMCID: PMC4245205.
    View in: PubMed Mentions: 50 Fields:
    Translation:HumansAnimalsCells
  35. Behavioral and neural correlates of acute and scheduled hunger in C57BL/6 mice. PLoS One. 2014; 9(5):e95990. Gallardo CM, Hsu CT, Gunapala KM, Parfyonov M, Chang CH, Mistlberger RE, Steele AD. PMID: 24806659; PMCID: PMC4012955.
    View in: PubMed Mentions: 19 Fields:
    Translation:Animals
  36. Cdc42 GTPase and Rac1 GTPase act downstream of p120 catenin and require GTP exchange during gastrulation of zebrafish mesoderm. Dev Dyn. 2012 Oct; 241(10):1545-61. Hsu CL, Muerdter CP, Knickerbocker AD, Walsh RM, Zepeda-Rivera MA, Depner KH, Sangesland M, Cisneros TB, Kim JY, Sanchez-Vazquez P, Cherezova L, Regan RD, Bahrami NM, Gray EA, Chan AY, Chen T, Rao MY, Hille MB. PMID: 22911626.
    View in: PubMed Mentions: 10 Fields:
    Translation:Animals
  37. Rare copy number variants are an important cause of epileptic encephalopathies. Ann Neurol. 2011 Dec; 70(6):974-85. Mefford HC, Yendle SC, Hsu C, Cook J, Geraghty E, McMahon JM, Eeg-Olofsson O, Sadleir LG, Gill D, Ben-Zeev B, Lerman-Sagie T, Mackay M, Freeman JL, Andermann E, Pelakanos JT, Andrews I, Wallace G, Eichler EE, Berkovic SF, Scheffer IE. PMID: 22190369; PMCID: PMC3245646.
    View in: PubMed Mentions: 101 Fields:
    Translation:HumansCells
  38. Visual disability variables. I: the importance and difficulty of activity goals for a sample of low-vision patients. Arch Phys Med Rehabil. 2005 May; 86(5):946-53. Massof RW, Hsu CT, Baker FH, Barnett GD, Park WL, Deremeik JT, Rainey C, Epstein C. PMID: 15895341.
    View in: PubMed Mentions: 29 Fields:
    Translation:Humans
  39. Visual disability variables. II: The difficulty of tasks for a sample of low-vision patients. Arch Phys Med Rehabil. 2005 May; 86(5):954-67. Massof RW, Hsu CT, Baker FH, Barnett GD, Park WL, Deremeik JT, Rainey C, Epstein C. PMID: 15895342.
    View in: PubMed Mentions: 33 Fields:
    Translation:Humans
  40. Acute posterior multifocal placoid pigment epitheliopathy associated with a systemic necrotizing vasculitis. Retina. 2003 Feb; 23(1):64-8. Hsu CT, Harlan JB, Goldberg MF, Dunn JP. PMID: 12652233.
    View in: PubMed Mentions: 13 Fields:
    Translation:Humans
  41. Optic neuropathy from folic acid deficiency without alcohol abuse. Ophthalmologica. 2002 Jan-Feb; 216(1):65-7. Hsu CT, Miller NR, Wray ML. PMID: 11901292.
    View in: PubMed Mentions: 13 Fields:
    Translation:Humans

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