David Coughlin • UCSD Profiles (original) (raw)

  1. CSF α-Synuclein Seed Amplification Assays and Skin Immunofluorescence: Clinical Applications, Research Opportunities, and Knowledge Gaps. Neurology. 2026 Feb 10; 106(3):e214648. Coughlin DG, Adler CH, Barbosa W, Feuerstein J, Galasko D, Gunzler SA, Jimenez-Shahed J, Kannarkat GT, Lang AE, Martinez-Lemus JD, LeWitt PA, Pantelyat A, Schiess MC, Schwarzschild M, Siderowf AD, Simuni T, Tropea TF, Thordarson D, Vila C, Adams JL, Rosenthal L, Parkinson Study Group Biomarkers Working Group. PMID: 41529231.
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    Translation:Humans
  2. CSF α-Synuclein Seed Amplification Assays and Alzheimer Disease Biomarkers in Dementia With Lewy Bodies: Presentation and Progression. Neurology. 2025 Dec 23; 105(12):e214346. Coughlin DG, Jain L, Khrestian M, Bozoki AC, Galvin JE, Irwin DJ, Lippa CF, Litvan I, Pillai JA, Tousi B, Lopez OL, Berman S, Tsuang DW, Zabetian CP, Fleisher JE, Taylor AS, Leverenz JB, Bekris LM, Galasko D, Dementia With Lewy Bodies Consortium. PMID: 41248454.
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  3. Neuropsychiatric symptom phenotypes for early detection of risk in older adults. Alzheimers Dement. 2025 Nov; 21(11):e70869. Erani F, Terao CM, Cooper S, Weigand AJ, Bangen KJ, Edmonds EC, Coughlin DG, Thomas KR. PMID: 41216845; PMCID: PMC12603784.
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  4. Reliability and modeling of digital histological measurements in Alzheimer's disease neuropathologic change and Lewy body disease. J Neuropathol Exp Neurol. 2025 Aug 01; 84(8):725-733. Kim Y, Andreasson T, Vishupad N, Benegal A, Pizzo D, Hansen L, Hiniker A, Coughlin D. PMID: 40272949; PMCID: PMC12277698.
    View in: PubMed Mentions: 1 Fields:
    Translation:Humans
  5. Sex and Racial/Ethnic Differences in End-of-Life Care Preferences in Persons with Parkinson's Disease and Related Disorders. Mov Disord. 2025 Sep; 40(9):1951-1964. Aamodt WW, Eickholt L, Coughlin DG, Solomon L, Rendle KA, Marshall C, Vizcarra JA, Dahodwala N. PMID: 40410929; PMCID: PMC12353931.
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  6. UTE MRI for assessing demyelination in an mTBI mouse model: An open-field low-intensity blast study. Neuroimage. 2025 Apr 15; 310:121103. Ma Y, Tang Q, Cheng X, Athertya JS, Coughlin D, Chang EY, Johnson CE, Cui J, Gu Z, Du J. PMID: 40024556; PMCID: PMC12372958.
    View in: PubMed Mentions: 1 Fields:
    Translation:AnimalsCells
  7. Early Alzheimer's Disease with frequent neuritic plaques harbors neocortical tau seeds distinct from primary age-related tauopathy. Nat Commun. 2025 Feb 21; 16(1):1851. Browne DF, Smirnov DS, Coughlin DG, Peng I, Standke HG, Kim Y, Pizzo DP, Unapanta A, Andreasson T, Hiniker A, Kraus A. PMID: 39984462; PMCID: PMC11845591.
    View in: PubMed Mentions: 1 Fields:
    Translation:HumansCells
  8. α-Synuclein Seed Amplification Assay Amplification Parameters and the Risk of Progression in Prodromal Parkinson Disease. Neurology. 2025 Mar 11; 104(5):e210279. Coughlin DG, Shifflett B, Farris CM, Ma Y, Galasko D, Edland SD, Mollenhauer B, Brumm MC, Poston KL, Marek K, Siderowf AD, Soto C, Concha-Marambio L, as the Investigators of the Parkinson's Progression Marker Initiative. PMID: 39913882; PMCID: PMC11803521.
    View in: PubMed Mentions: 2 Fields:
    Translation:Humans
  9. Sex differences for regional pathology in people with a high likelihood of Lewy body dementia phenotype based on underlying pathology. Alzheimers Dement (Amst). 2025 Jan-Mar; 17(1):e70083. Bayram E, Coughlin DG, Koga S, Ross OA, Litvan I, Dickson DW. PMID: 39886324; PMCID: PMC11780110.
    View in: PubMed Mentions: 2
  10. Association of CSF α-Synuclein Seeding Amplification Assay Results With Clinical Features of Possible and Probable Dementia With Lewy Bodies. Neurology. 2024 Aug 13; 103(3):e209656. Coughlin DG, MacLeod KR, Middleton JS, Bozoki AC, Galvin JE, Irwin DJ, Lippa CF, Litvan I, Lopez OL, Berman S, Tsuang DW, Zabetian CP, Honig LS, Marder KS, Fleisher JE, Sabbagh M, Wint D, Taylor AS, Bekris L, Leverenz JB, Galasko D. PMID: 39013126; PMCID: PMC11238940.
    View in: PubMed Mentions: 10 Fields:
    Translation:Humans
  11. Sex differences for clinical correlates of substantia nigra neuron loss in people with Lewy body pathology. Biol Sex Differ. 2024 Jan 19; 15(1):8. Bayram E, Coughlin DG, Rajmohan R, Litvan I. PMID: 38243325; PMCID: PMC10797801.
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    Translation:HumansCells
  12. TDP43 pathology in chronic traumatic encephalopathy retinas. Acta Neuropathol Commun. 2023 09 22; 11(1):152. Phansalkar R, Goodwill VS, Nirschl JJ, De Lillo C, Choi J, Spurlock E, Coughlin DG, Pizzo D, Sigurdson CJ, Hiniker A, Alvarez VE, Mckee AC, Lin JH. PMID: 37737191; PMCID: PMC10515050.
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    Translation:Humans
  13. Nitrous Oxide Toxicity With Subsequent Recovery. Neurology. 2023 10 10; 101(15):674-675. DiPane J, Tiem M, Wright BA, Qayoumi W, Coughlin DG. PMID: 37487745; PMCID: PMC10585688.
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    Translation:Humans
  14. Case report: Neuronal intranuclear inclusion disease presenting with acute encephalopathy. Front Neurol. 2023; 14:1184612. Bu JT, Torres D, Robinson A, Malone C, Vera JC, Daghighi S, Dunn-Pirio A, Khoromi S, Nowell J, Léger GC, Ciacci JD, Goodwill VS, Estrella M, Coughlin DG, Guo Y, Farid N. PMID: 37332983; PMCID: PMC10272712.
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  15. Tau seeds occur before earliest Alzheimer's changes and are prevalent across neurodegenerative diseases. Acta Neuropathol. 2023 07; 146(1):31-50. Manca M, Standke HG, Browne DF, Huntley ML, Thomas OR, Orrú CD, Hughson AG, Kim Y, Zhang J, Tatsuoka C, Zhu X, Hiniker A, Coughlin DG, Galasko D, Kraus A. PMID: 37154939; PMCID: PMC10261243.
    View in: PubMed Mentions: 15 Fields:
    Translation:Humans
  16. Fluid and Biopsy Based Biomarkers in Parkinson's Disease. Neurotherapeutics. 2023 07; 20(4):932-954. Coughlin DG, Irwin DJ. PMID: 37138160; PMCID: PMC10457253.
    View in: PubMed Mentions: 23 Fields:
    Translation:Humans
  17. Metabolic reprogramming underlies cavefish muscular endurance despite loss of muscle mass and contractility. Proc Natl Acad Sci U S A. 2023 01 31; 120(5):e2204427120. Olsen L, Levy M, Medley JK, Hassan H, Miller B, Alexander R, Wilcock E, Yi K, Florens L, Weaver K, McKinney SA, Peuß R, Persons J, Kenzior A, Maldonado E, Delventhal K, Gluesenkamp A, Mager E, Coughlin D, Rohner N. PMID: 36693105; PMCID: PMC9945943.
    View in: PubMed Mentions: 15 Fields:
    Translation:HumansAnimals
  18. Digital Histological Study of Neocortical Grey and White Matter Tau Burden Across Tauopathies. J Neuropathol Exp Neurol. 2022 11 16; 81(12):953-964. Coughlin DG, Hiniker A, Peterson C, Kim Y, Arezoumandan S, Giannini L, Pizzo D, Weintraub D, Siderowf A, Litvan I, Rissman RA, Galasko D, Hansen L, Trojanowski JQ, Lee E, Grossman M, Irwin D. PMID: 36269086; PMCID: PMC9677241.
    View in: PubMed Mentions: 6 Fields:
    Translation:Humans
  19. Perception of Fragmented Letters by Patients With Pathologically Confirmed Dementia With Lewy Bodies or Alzheimer Disease. Neurology. 2022 11 01; 99(18):e2034-e2043. Salmon DP, Smirnov DS, Coughlin DG, Hamilton JM, Landy KM, Filoteo JV, Hiniker A, Hansen LA, Galasko D. PMID: 36028327; PMCID: PMC9651460.
    View in: PubMed Mentions: 4 Fields:
    Translation:HumansCells
  20. Selective tau seeding assays and isoform-specific antibodies define neuroanatomic distribution of progressive supranuclear palsy pathology arising in Alzheimer's disease. Acta Neuropathol. 2022 10; 144(4):789-792. Coughlin DG, Goodwill VS, Standke HG, Kim Y, Coley N, Pizzo DP, Galasko D, Kraus A, Hiniker A. PMID: 35980456; PMCID: PMC9467964.
    View in: PubMed Mentions: 4 Fields:
    Translation:Humans
  21. α-Synuclein Seed Amplification in CSF and Brain from Patients with Different Brain Distributions of Pathological α-Synuclein in the Context of Co-Pathology and Non-LBD Diagnoses. Ann Neurol. 2022 10; 92(4):650-662. Arnold MR, Coughlin DG, Brumbach BH, Smirnov DS, Concha-Marambio L, Farris CM, Ma Y, Kim Y, Wilson EN, Kaye JA, Hiniker A, Woltjer RL, Galasko DR, Quinn JF. PMID: 35808984; PMCID: PMC9489647.
    View in: PubMed Mentions: 59 Fields:
    Translation:Humans
  22. Investigational therapeutics for the treatment of progressive supranuclear palsy. Expert Opin Investig Drugs. 2022 Aug; 31(8):813-823. Coughlin DG, Litvan I. PMID: 35695010.
    View in: PubMed Mentions: 2 Fields:
    Translation:Humans
  23. Lateralized ante mortem and post mortem pathology in a case of Lewy body disease with corticobasal syndrome. Alzheimers Dement (N Y). 2022; 8(1):e12294. Coughlin DG, Coslett HB, Peterson C, Phillips JS, McMillan C, Lee EB, Trojanowski JQ, Grossman M, Irwin DJ. PMID: 35592691; PMCID: PMC9092750.
    View in: PubMed Mentions: 2
  24. Sex Differences for Clinical Correlates of Alzheimer's Pathology in People with Lewy Body Pathology. Mov Disord. 2022 07; 37(7):1505-1515. Bayram E, Coughlin DG, Litvan I. PMID: 35531707; PMCID: PMC9308759.
    View in: PubMed Mentions: 19 Fields:
    Translation:HumansCells
  25. Tau deposition patterns are associated with functional connectivity in primary tauopathies. Nat Commun. 2022 03 15; 13(1):1362. Franzmeier N, Brendel M, Beyer L, Slemann L, Kovacs GG, Arzberger T, Kurz C, Respondek G, Lukic MJ, Biel D, Rubinski A, Frontzkowski L, Hummel S, Müller A, Finze A, Palleis C, Joseph E, Weidinger E, Katzdobler S, Song M, Biechele G, Kern M, Scheifele M, Rauchmann BS, Perneczky R, Rullman M, Patt M, Schildan A, Barthel H, Sabri O, Rumpf JJ, Schroeter ML, Classen J, Villemagne V, Seibyl J, Stephens AW, Lee EB, Coughlin DG, Giese A, Grossman M, McMillan CT, Gelpi E, Molina-Porcel L, Compta Y, van Swieten JC, Laat LD, Troakes C, Al-Sarraj S, Robinson JL, Xie SX, Irwin DJ, Roeber S, Herms J, Simons M, Bartenstein P, Lee VM, Trojanowski JQ, Levin J, Höglinger G, Ewers M. PMID: 35292638; PMCID: PMC8924216.
    View in: PubMed Mentions: 49 Fields:
    Translation:Humans
  26. Physician-Assisted Dying: Access and Utilization in Patients with Movement Disorders. Mov Disord. 2022 04; 37(4):694-698. Damron L, Bayram E, McGehrin K, Reynolds J, Hess R, Coughlin DG, Litvan I. PMID: 35218063.
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    Translation:Humans
  27. Neuropathological substrates of cognition in Parkinson's disease. Prog Brain Res. 2022; 269(1):177-193. Coughlin DG, Irwin DJ. PMID: 35248194.
    View in: PubMed Mentions: 3 Fields:
    Translation:HumansCells
  28. Long-standing multiple system atrophy-Parkinsonism with limbic and FTLD-type α-synuclein pathology. Neuropathol Appl Neurobiol. 2022 04; 48(3):e12783. Coughlin DG, Dryden I, Goodwill VS, Pizzo DP, Wright B, Lessig S, Galasko D, MacKenzie IR, Hiniker A. PMID: 34847258; PMCID: PMC9097824.
    View in: PubMed Mentions: 6 Fields:
    Translation:Humans
  29. A Case of Frontotemporal Lobar Degeneration With FUS-Positive Pathology (FTLD-FET) With Corticobasal Features and Language Deficits. J Neuropathol Exp Neurol. 2021 09 27; 80(9):890-892. Goodwill V, Coughlin D, Pizzo D, Galasko D, Hansen LA, Yuan SH, Hiniker A. PMID: 33969424; PMCID: PMC8476078.
    View in: PubMed Mentions: 1 Fields:
    Translation:Humans
  30. Hippocampal subfield pathologic Burden in Lewy body diseases versus Alzheimer's disease. Neuropathol Appl Neurobiol. 2021 08; 47(5):707-708. Coughlin DG, Grossman M, Trojanowski JQ, Irwin DJ. PMID: 33492664; PMCID: PMC8298266.
    View in: PubMed Mentions: 2 Fields:
    Translation:Humans
  31. Sex differences for phenotype in pathologically defined dementia with Lewy bodies. J Neurol Neurosurg Psychiatry. 2021 07; 92(7):745-750. Bayram E, Coughlin DG, Banks SJ, Litvan I. PMID: 33563809; PMCID: PMC8530264.
    View in: PubMed Mentions: 28 Fields:
    Translation:Humans
  32. Progressive Supranuclear Palsy and Corticobasal Degeneration. Adv Exp Med Biol. 2021; 1281:151-176. Coughlin DG, Dickson DW, Josephs KA, Litvan I. PMID: 33433875.
    View in: PubMed Mentions: 16 Fields:
    Translation:Humans
  33. Tau pathology associates with in vivo cortical thinning in Lewy body disorders. Ann Clin Transl Neurol. 2020 12; 7(12):2342-2355. Spotorno N, Coughlin DG, Olm CA, Wolk D, Vaishnavi SN, Shaw LM, Dahodwala N, Morley JF, Duda JE, Deik AF, Spindler MA, Chen-Plotkin A, Lee EB, Trojanowski JQ, McMillan CT, Weintraub D, Grossman M, Irwin DJ. PMID: 33108692; PMCID: PMC7732256.
    View in: PubMed Mentions: 22 Fields:
    Translation:Humans
  34. Multimodal in vivo and postmortem assessments of tau in Lewy body disorders. Neurobiol Aging. 2020 12; 96:137-147. Coughlin DG, Phillips JS, Roll E, Peterson C, Lobrovich R, Rascovsky K, Ungrady M, Wolk DA, Das S, Weintraub D, Lee EB, Trojanowski JQ, Shaw LM, Vaishnavi S, Siderowf A, Nasrallah IM, Irwin DJ, McMillan CT, Alzheimer’s Disease Neuroimaging Initiative. PMID: 33002767; PMCID: PMC7819484.
    View in: PubMed Mentions: 19 Fields:
    Translation:Humans
  35. Progressive supranuclear palsy: Advances in diagnosis and management. Parkinsonism Relat Disord. 2020 04; 73:105-116. Coughlin DG, Litvan I. PMID: 32487421; PMCID: PMC7462164.
    View in: PubMed Mentions: 48 Fields:
    Translation:Humans
  36. Distribution patterns of tau pathology in progressive supranuclear palsy. Acta Neuropathol. 2020 08; 140(2):99-119. Kovacs GG, Lukic MJ, Irwin DJ, Arzberger T, Respondek G, Lee EB, Coughlin D, Giese A, Grossman M, Kurz C, McMillan CT, Gelpi E, Compta Y, van Swieten JC, Laat LD, Troakes C, Al-Sarraj S, Robinson JL, Roeber S, Xie SX, Lee VM, Trojanowski JQ, Höglinger GU. PMID: 32383020; PMCID: PMC7360645.
    View in: PubMed Mentions: 230 Fields:
    Translation:Humans
  37. Pathological Influences on Clinical Heterogeneity in Lewy Body Diseases. Mov Disord. 2020 01; 35(1):5-19. Coughlin DG, Hurtig HI, Irwin DJ. PMID: 31660655; PMCID: PMC7233798.
    View in: PubMed Mentions: 55 Fields:
    Translation:HumansCells
  38. Most cases with Lewy pathology in a population-based cohort adhere to the Braak progression pattern but 'failure to fit' is highly dependent on staging system applied. Parkinsonism Relat Disord. 2019 07; 64:124-131. Coughlin DG, Petrovitch H, White LR, Noorigian J, Masaki KH, Ross GW, Duda JE. PMID: 30948243; PMCID: PMC6739131.
    View in: PubMed Mentions: 17 Fields:
    Translation:HumansCells
  39. Cognitive and Pathological Influences of Tau Pathology in Lewy Body Disorders. Ann Neurol. 2019 02; 85(2):259-271. Coughlin D, Xie SX, Liang M, Williams A, Peterson C, Weintraub D, McMillan CT, Wolk DA, Akhtar RS, Hurtig HI, Branch Coslett H, Hamilton RH, Siderowf AD, Duda JE, Rascovsky K, Lee EB, Lee VM, Grossman M, Trojanowski JQ, Irwin DJ. PMID: 30549331; PMCID: PMC6375484.
    View in: PubMed Mentions: 85 Fields:
    Translation:Humans
  40. Preventing Early Bouncebacks to the Neurointensive Care Unit: A Retrospective Analysis and Quality Improvement Pilot. Neurocrit Care. 2018 04; 28(2):175-183. Coughlin DG, Kumar MA, Patel NN, Hoffman RL, Kasner SE. PMID: 28929392.
    View in: PubMed Mentions: 5 Fields:
    Translation:Humans
  41. Hereditary Myoclonus Dystonia: A Novel SGCE Variant and Phenotype Including Intellectual Disability. Tremor Other Hyperkinet Mov (N Y). 2018; 8:547. Coughlin DG, Bardakjian TM, Spindler M, Deik A. PMID: 29607243; PMCID: PMC5876472.
    View in: PubMed Mentions: 2 Fields:
    Translation:Humans
  42. CSF tau and β-amyloid predict cerebral synucleinopathy in autopsied Lewy body disorders. Neurology. 2018 03 20; 90(12):e1038-e1046. Irwin DJ, Xie SX, Coughlin D, Nevler N, Akhtar RS, McMillan CT, Lee EB, Wolk DA, Weintraub D, Chen-Plotkin A, Duda JE, Spindler M, Siderowf A, Hurtig HI, Shaw LM, Grossman M, Trojanowski JQ. PMID: 29467305; PMCID: PMC5874449.
    View in: PubMed Mentions: 48 Fields:
    Translation:HumansCells
  43. Emerging Diagnostic and Therapeutic Strategies for Tauopathies. Curr Neurol Neurosci Rep. 2017 Sep; 17(9):72. Coughlin D, Irwin DJ. PMID: 28785992; PMCID: PMC5756477.
    View in: PubMed Mentions: 16 Fields:
    Translation:HumansAnimals
  44. Epileptogenic but MRI-normal perituberal tissue in Tuberous Sclerosis Complex contains tuber-specific abnormalities. Acta Neuropathol Commun. 2015 Apr 02; 3:17. Sosunov AA, McGovern RA, Mikell CB, Wu X, Coughlin DG, Crino PB, Weiner HL, Ghatan S, Goldman JE, McKhann GM. PMID: 25853525; PMCID: PMC4383198.
    View in: PubMed Mentions: 13 Fields:
    Translation:HumansCells
  45. The mTOR pathway is activated in glial cells in mesial temporal sclerosis. Epilepsia. 2012 Jun; 53 Suppl 1:78-86. Sosunov AA, Wu X, McGovern RA, Coughlin DG, Mikell CB, Goodman RR, McKhann GM. PMID: 22612812.
    View in: PubMed Mentions: 37 Fields:
    Translation:HumansAnimalsCells

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