Lawrence Liu • UCSD Profiles (original) (raw)
- Structure-Activity Relationship and Target Investigation of Thiophen-2-yl-Pyrimidines against Schistosoma species. bioRxiv. 2025 Oct 08. Francisco KR, Lucero B, Yohannan D, Varricchio C, Lam A, Sebastiani J, Liu LJ, Sun YU, Jacinto J, Renzulli M, Monti L, Brancale A, Ballatore C, Alle T, Caffrey CR. PMID: 41279673; PMCID: PMC12632319.
View in: PubMed Mentions: - Discovery of small molecules with anthelmintic potential in the Medicines for Malaria Venture's COVID and Global Health Priority Boxes using an infrared-based assay for Caenorhabditis elegans motility. BMC Res Notes. 2025 Oct 06; 18(1):422. Sun YU, Liu LJ, Caffrey CR. PMID: 41053889; PMCID: PMC12502323.
View in: PubMed Mentions: 1 Fields:
Translation:HumansAnimalsCells - Enhancing schistosomiasis drug discovery approaches with optimized proteasome substrates. Protein Sci. 2025 Jun; 34(6):e70180. Silva EB, Jiang Z, Liu C, Fajtová P, Teixeira TR, de Castro Fiorini Maia G, Liu LJ, El-Sakkary N, Skinner DE, Syed A, Wang SC, Caffrey CR, O'Donoghue AJ. PMID: 40411405; PMCID: PMC12102734.
View in: PubMed Mentions: 1 Fields:
Translation:HumansAnimals - An in vitro platform for the enzymatic characterization of the rhomboid protease RHBDL4. J Biol Chem. 2025 03; 301(3):108275. Bhaduri S, Braza MKE, Stanchev S, Tauber M, Al-Bawab R, Liu LJ, Trujillo DF, Solorio-Kirpichyan K, Srivastava A, Sanlley-Hernandez J, O'Donoghue AJ, Lemberg MK, Amaro R, Strisovsky K, Neal SE. PMID: 39922490; PMCID: PMC11929074.
View in: PubMed Mentions: Fields:
Translation:HumansCells - Distinct substrate specificities of the three catalytic subunits of the Trichomonas vaginalis proteasome. Protein Sci. 2024 Dec; 33(12):e5225. Fajtova P, Hurysz BM, Miyamoto Y, Serafim MSM, Jiang Z, Vazquez JM, Trujillo DF, Liu LJ, Somani U, Almaliti J, Myers SA, Caffrey CR, Gerwick WH, McMinn DL, Kirk CJ, Boura E, Eckmann L, O'Donoghue AJ. PMID: 39589076; PMCID: PMC11590128.
View in: PubMed Mentions: 6 Fields:
Translation:AnimalsCells - Carmaphycin B-Based Proteasome Inhibitors to Treat Human African Trypanosomiasis: Structure-Activity Relationship and In Vivo Efficacy. ACS Infect Dis. 2024 12 13; 10(12):4182-4193. Liu LJ, Francisco KR, Sun YU, Serafim MSM, Amarasinghe DK, Teixeira TR, Lucero B, Kronenberger T, Elsayed W, Elwakeel H, Al-Hindy M, Almaliti J, Gerwick WH, O'Donoghue AJ, Caffrey CR. PMID: 39589805; PMCID: PMC11650654.
View in: PubMed Mentions: 4 Fields:
Translation:HumansAnimals - Structure activity relationships of antischistosomal N-phenylbenzamides by incorporation of electron-withdrawing functionalities. Results Chem. 2024 Dec; 12. Dawoodjee AM, Sichinga J, Banda H, Mbaya S, Funjika E, Mayoka G, Hikaambo C, Francisco KR, Sun YU, Liu LJ, Caffrey CR, Cheuka PM. PMID: 40129570; PMCID: PMC11932705.
View in: PubMed Mentions: - An in vitro platform for the enzymatic characterization of the rhomboid protease RHBDL4. bioRxiv. 2024 Oct 17. Bhaduri S, Braza MKE, Stanchev S, Tauber M, Al-Bawab R, Liu LJ, Trujillo DF, Solorio-Kirpichyan K, Srivastava A, Sanlley-Hernandez J, O'Donoghue AJ, Lemberg MK, Amario R, Strisovsky K, Neal SE. PMID: 39415989; PMCID: PMC11483055.
View in: PubMed Mentions: - The proteasome as a drug target for treatment of parasitic diseases. Adv Parasitol. 2024; 126:53-96. Liu LJ, O'Donoghue AJ, Caffrey CR. PMID: 39448194.
View in: PubMed Mentions: 2 Fields:
Translation:HumansAnimals - Clickable Probes for Pathogen Proteasomes: Synthesis and Applications. ACS Omega. 2024 Aug 13; 9(32):34829-34840. Liu LJ, Lucero B, Manriquez-Rodriguez C, Francisco KR, Teixeira TR, Yohannan DJ, Ballatore C, Myers SA, O'Donoghue AJ, Caffrey CR. PMID: 39157084; PMCID: PMC11325529.
View in: PubMed Mentions: - Pharmacophore Virtual Screening Identifies Riboflavin as an Inhibitor of the Schistosome Cathepsin B1 Protease with Antiparasitic Activity. ACS Omega. 2024 Jun 11; 9(23):25356-25369. Cogo RM, Pavani TFA, Mengarda ACA, Cajas RA, Teixeira TR, Fukui-Silva L, Sun YU, Liu LJ, Amarasinghe DK, Yoon MC, Santos-Filho OA, de Moraes J, Caffrey CR, G G Rando D. PMID: 38882094; PMCID: PMC11170711.
View in: PubMed Mentions: 2 - Development of subunit selective proteasome substrates for Schistosoma species. bioRxiv. 2024 Feb 14. Jiang Z, Silva EB, Liu C, Fajtová P, Liu LJ, El-Sakkary N, Skinner DE, Syed A, Wang SC, Caffrey CR, O'Donoghue AJ. PMID: 38405969; PMCID: PMC10888821.
View in: PubMed Mentions: - Design, Synthesis, and Evaluation of An Anti-trypanosomal [1,2,4]Triazolo[1,5-a]pyrimidine Probe for Photoaffinity Labeling Studies. ChemMedChem. 2024 04 16; 19(8):e202300656. Lucero B, Francisco KR, Varricchio C, Liu LJ, Yao Y, Brancale A, Brunden KR, Caffrey CR, Ballatore C. PMID: 38277231; PMCID: PMC11031298.
View in: PubMed Mentions: 2 Fields:
Translation:HumansAnimalsCells - Structure-Activity Relationships, Tolerability and Efficacy of Microtubule-Active 1,2,4-Triazolo[1,5-a]pyrimidines as Potential Candidates to Treat Human African Trypanosomiasis. ChemMedChem. 2023 10 17; 18(20):e202300193. Monti L, Liu LJ, Varricchio C, Lucero B, Alle T, Yang W, Bem-Shalom I, Gilson M, Brunden KR, Brancale A, Caffrey CR, Ballatore C. PMID: 37429821; PMCID: PMC10615688.
View in: PubMed Mentions: 4 Fields:
Translation:HumansAnimalsCells - Chemoproteomic identification of a DPP4 homolog in Bacteroides thetaiotaomicron. Nat Chem Biol. 2023 12; 19(12):1469-1479. Keller LJ, Nguyen TH, Liu LJ, Hurysz BM, Lakemeyer M, Guerra M, Gelsinger DJ, Chanin R, Ngo N, Lum KM, Faucher F, Ipock P, Niphakis MJ, Bhatt AS, O'Donoghue AJ, Huang KC, Bogyo M. PMID: 37349583.
View in: PubMed Mentions: 12 Fields:
Translation:HumansCells - Protein-protein interactions: developing small-molecule inhibitors/stabilizers through covalent strategies. Trends Pharmacol Sci. 2023 07; 44(7):474-488. Lucero B, Francisco KR, Liu LJ, Caffrey CR, Ballatore C. PMID: 37263826; PMCID: PMC11003449.
View in: PubMed Mentions: 13 Fields:
Translation:HumansCells - Structure-Activity Relationships, Tolerability and Efficacy of Microtubule-Active 1,2,4-Triazolo[1,5- a ]pyrimidines as Potential Candidates to Treat Human African Trypanosomiasis. bioRxiv. 2023 Mar 11. Monti L, Liu LJ, Varricchio C, Lucero B, Alle T, Yang W, Bem-Shalom I, Gilson M, Brunden KR, Brancale A, Caffrey CR, Ballatore C. PMID: 36945407; PMCID: PMC10028969.
View in: PubMed Mentions: - Activity of N-phenylbenzamide analogs against the neglected disease pathogen, Schistosoma mansoni. Bioorg Med Chem Lett. 2023 02 15; 82:129164. Kanyanta M, Lengwe C, Mambwe D, Francisco KR, Liu LJ, Uli Sun Y, Amarasinghe DK, Caffrey CR, Mubanga Cheuka P. PMID: 36736493; PMCID: PMC10072318.
View in: PubMed Mentions: 3 Fields:
Translation:HumansAnimalsCells - Structure-activity relationship of dibenzylideneacetone analogs against the neglected disease pathogen, Trypanosoma brucei. Bioorg Med Chem Lett. 2023 02 01; 81:129123. Francisco KR, Monti L, Yang W, Park H, Liu LJ, Watkins K, Amarasinghe DK, Nalli M, Roberto Polaquini C, Regasini LO, Eduardo Miller Crotti A, Silvestri R, Guidi Magalhães L, Caffrey CR. PMID: 36608774; PMCID: PMC10072319.
View in: PubMed Mentions: 10 Fields:
Translation:HumansAnimalsCells - A Broad Spectrum Antiparasitic Activity of Organotin (IV) Derivatives and Its Untargeted Proteomic Profiling Using Leishmania donovani. Pathogens. 2022 Nov 26; 11(12). Hayat O, Ullah N, Sirajuddin M, Giardini MA, Nguyen JV, Francisco KR, Liu LJ, Sun YU, Maurya S, McGrosso D, Gonzalez DJ, Caffrey CR, Debnath A, Siqueira-Neto JL. PMID: 36558759; PMCID: PMC9785441.
View in: PubMed Mentions: 3 Fields: - Identification of Inhibitors of the Schistosoma mansoni VKR2 Kinase Domain. ACS Med Chem Lett. 2022 Nov 10; 13(11):1715-1722. Mathavan I, Liu LJ, Robinson SW, El-Sakkary N, Elatico AJJ, Gomez D, Nellas R, Owens RJ, Zuercher W, Navratilova I, Caffrey CR, Beis K. PMID: 36385939; PMCID: PMC9661718.
View in: PubMed Mentions: 3 - Anti-schistosomal activities of quinoxaline-containing compounds: From hit identification to lead optimisation. Eur J Med Chem. 2021 Dec 15; 226:113823. Padalino G, El-Sakkary N, Liu LJ, Liu C, Harte DSG, Barnes RE, Sayers E, Forde-Thomas J, Whiteland H, Bassetto M, Ferla S, Johnson G, Jones AT, Caffrey CR, Chalmers I, Brancale A, Hoffmann KF. PMID: 34536671; PMCID: PMC8626775.
View in: PubMed Mentions: 9 Fields:
Translation:HumansAnimalsCells - A Machine Learning Strategy for Drug Discovery Identifies Anti-Schistosomal Small Molecules. ACS Infect Dis. 2021 02 12; 7(2):406-420. Zorn KM, Sun S, McConnon CL, Ma K, Chen EK, Foil DH, Lane TR, Liu LJ, El-Sakkary N, Skinner DE, Ekins S, Caffrey CR. PMID: 33434015; PMCID: PMC7887754.
View in: PubMed Mentions: 11 Fields:
Translation:Animals - Congeners Derived from Microtubule-Active Phenylpyrimidines Produce a Potent and Long-Lasting Paralysis of Schistosoma mansoni In Vitro. ACS Infect Dis. 2021 05 14; 7(5):1089-1103. Monti L, Cornec AS, Oukoloff K, Kovalevich J, Prijs K, Alle T, Brunden KR, Smith AB, El-Sakkary N, Liu LJ, Syed A, Skinner DE, Ballatore C, Caffrey CR. PMID: 33135408; PMCID: PMC8641298.
View in: PubMed Mentions: 9 Fields:
Translation:HumansAnimalsCells
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This graph shows the number and percent of publications by field. Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications. Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written. To see the data as text, click here.
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