Roi Isaac • UCSD Profiles (original) (raw)
- CCL26 and CXCL12 preserve insulin-sensitizing macrophages in subcutaneous adipose tissue in obesity. Cell Rep. 2025 Oct 28; 44(10):116450. Jeelani I, Franco da Cunha F, Rohm TV, Nasamran CA, Wang L, Moon JS, Prakash S, Oswari J, Isaac R, Murphy C, Glass CK, Olefsky JM, Lee YS. PMID: 41100258; PMCID: PMC12587491.
View in: PubMed Mentions: 1 Fields:
Translation:HumansAnimalsCells - Adipose Tissue Macrophages in Metabolic Dysfunction-Associated Steatohepatitis Secrete Extracellular Vesicles That Activate Liver Fibrosis in Obese Male Mice. Gastroenterology. 2025 Sep; 169(4):691-704.e9. Rohm TV, Dos Reis FCG, Cunha E Rocha K, Isaac R, Strayer S, Murphy C, Bandyopadhyay G, Gao H, Ganguly S, Nguyen T, Wang J, Youhanna JE, Pack D, Liu X, Kim HY, Jeelani I, Dhar D, Kisseleva T, Ying W, Olefsky JM. PMID: 40204101.
View in: PubMed Mentions: 5 Fields:
Translation:AnimalsCells - Metabolic Dysfunction-Associated Steatohepatitis Adipose Tissue Macrophages Secrete Extracellular Vesicles That Activate Liver Fibrosis in Obese Male Mice. Gastroenterology. 2025 Apr 09. Rohm TV, Dos Reis FCG, Cunha E Rocha K, Isaac R, Strayer S, Murphy C, Bandyopadhyay G, Gao H, Ganguly S, Nguyen T, Wang J, Youhanna JE, Pack D, Liu X, Kim HY, Jeelani I, Dhar D, Kisseleva T, Ying W, Olefsky JM. PMID: 40204101.
View in: PubMed Mentions: 5 Fields:
Translation:AnimalsCells - Author Correction: Adipose tissue macrophages secrete small extracellular vesicles that mediate rosiglitazone-induced insulin sensitization. Nat Metab. 2024 Aug; 6(8):1646. Rohm TV, Castellani Gomes Dos Reis F, Isaac R, Murphy C, Cunha E Rocha K, Bandyopadhyay G, Gao H, Libster AM, Zapata RC, Lee YS, Ying W, Miciano C, Wang A, Olefsky JM. PMID: 38969830.
View in: PubMed Mentions: 1 Fields: - TM7SF3 controls TEAD1 splicing to prevent MASH-induced liver fibrosis. Cell Metab. 2024 May 07; 36(5):1030-1043.e7. Isaac R, Bandyopadhyay G, Rohm TV, Kang S, Wang J, Pokhrel N, Sakane S, Zapata R, Libster AM, Vinik Y, Berhan A, Kisseleva T, Borok Z, Zick Y, Telese F, Webster NJG, Olefsky JM. PMID: 38670107; PMCID: PMC11113091.
View in: PubMed Mentions: 12 Fields:
Translation:HumansAnimalsCells - Adipose tissue macrophages secrete small extracellular vesicles that mediate rosiglitazone-induced insulin sensitization. Nat Metab. 2024 May; 6(5):880-898. Rohm TV, Castellani Gomes Dos Reis F, Isaac R, Murphy C, Cunha E Rocha K, Bandyopadhyay G, Gao H, Libster AM, Zapata RC, Lee YS, Ying W, Miciano C, Wang A, Olefsky JM. PMID: 38605183; PMCID: PMC11430498.
View in: PubMed Mentions: 27 Fields:
Translation:HumansAnimalsCells - Human gain-of-function variants in HNF1A confer protection from diabetes but independently increase hepatic secretion of atherogenic lipoproteins. Cell Genom. 2023 Jul 12; 3(7):100339. DeForest N, Kavitha B, Hu S, Isaac R, Krohn L, Wang M, Du X, De Arruda Saldanha C, Gylys J, Merli E, Abagyan R, Najmi L, Mohan V, Alnylam Human Genetics, AMP-T2D Consortium, Flannick J, Peloso GM, Gordts PLSM, Heinz S, Deaton AM, Khera AV, Olefsky J, Radha V, Majithia AR. PMID: 37492105; PMCID: PMC10363808.
View in: PubMed Mentions: 13 Fields: - A seven-transmembrane protein-TM7SF3, resides in nuclear speckles and regulates alternative splicing. iScience. 2022 Nov 18; 25(11):105270. Isaac R, Vinik Y, Mikl M, Nadav-Eliyahu S, Shatz-Azoulay H, Yaakobi A, DeForest N, Majithia AR, Webster NJG, Shav-Tal Y, Elhanany E, Zick Y. PMID: 36304109; PMCID: PMC9593240.
View in: PubMed Mentions: 1 - HIF-2α Preserves Mitochondrial Activity and Glucose Sensing in Compensating β-Cells in Obesity. Diabetes. 2022 07 01; 71(7):1508-1524. Moon JS, Riopel M, Seo JB, Herrero-Aguayo V, Isaac R, Lee YS. PMID: 35472707; PMCID: PMC9233300.
View in: PubMed Mentions: 10 Fields:
Translation:Animals - Cancer-cell-secreted extracellular vesicles suppress insulin secretion through miR-122 to impair systemic glucose homeostasis and contribute to tumour growth. Nat Cell Biol. 2022 06; 24(6):954-967. Cao M, Isaac R, Yan W, Ruan X, Jiang L, Wan Y, Wang J, Wang E, Caron C, Neben S, Drygin D, Pizzo DP, Wu X, Liu X, Chin AR, Fong MY, Gao Z, Guo K, Fadare O, Schwab RB, Yuan Y, Yost SE, Mortimer J, Zhong W, Ying W, Bui JD, Sears DD, Olefsky JM, Wang SE. PMID: 35637408; PMCID: PMC9233030.
View in: PubMed Mentions: 73 Fields:
Translation:HumansAnimalsCells - Exosomes as mediators of intercellular crosstalk in metabolism. Cell Metab. 2021 09 07; 33(9):1744-1762. Isaac R, Reis FCG, Ying W, Olefsky JM. PMID: 34496230; PMCID: PMC8428804.
View in: PubMed Mentions: 386 Fields:
Translation:HumansCells - Hepatocyte-derived exosomes from early onset obese mice promote insulin sensitivity through miR-3075. Nat Metab. 2021 09; 3(9):1163-1174. Ji Y, Luo Z, Gao H, Dos Reis FCG, Bandyopadhyay G, Jin Z, Manda KA, Isaac R, Yang M, Fu W, Ying W, Olefsky JM. PMID: 34489604; PMCID: PMC8460610.
View in: PubMed Mentions: 56 Fields:
Translation:AnimalsCells - TAZ Is a Negative Regulator of PPARγ Activity in Adipocytes and TAZ Deletion Improves Insulin Sensitivity and Glucose Tolerance. Cell Metab. 2020 01 07; 31(1):162-173.e5. El Ouarrat D, Isaac R, Lee YS, Oh DY, Wollam J, Lackey D, Riopel M, Bandyopadhyay G, Seo JB, Sampath-Kumar R, Olefsky JM. PMID: 31708444; PMCID: PMC7784082.
View in: PubMed Mentions: 59 Fields:
Translation:HumansAnimalsCells - Adipocyte PU.1 knockout promotes insulin sensitivity in HFD-fed obese mice. Sci Rep. 2019 10 14; 9(1):14779. Lackey DE, Reis FCG, Isaac R, Zapata RC, El Ouarrat D, Lee YS, Bandyopadhyay G, Ofrecio JM, Oh DY, Osborn O. PMID: 31611602; PMCID: PMC6791934.
View in: PubMed Mentions: 8 Fields:
Translation:AnimalsCells - Expansion of Islet-Resident Macrophages Leads to Inflammation Affecting β Cell Proliferation and Function in Obesity. Cell Metab. 2019 02 05; 29(2):457-474.e5. Ying W, Lee YS, Dong Y, Seidman JS, Yang M, Isaac R, Seo JB, Yang BH, Wollam J, Riopel M, McNelis J, Glass CK, Olefsky JM, Fu W. PMID: 30595478; PMCID: PMC6701710.
View in: PubMed Mentions: 152 Fields:
Translation:AnimalsCells - Prolonged Elimination of Negative Feedback Control Mechanisms Along the Insulin Signaling Pathway Impairs β-Cell Function In Vivo. Diabetes. 2017 07; 66(7):1879-1889. Isaac R, Vinik Y, Boura-Halfon S, Farack L, Streim S, Elhanany E, Kam Z, Zick Y. PMID: 28424159.
View in: PubMed Mentions: 1 Fields:
Translation:AnimalsCells - Nedd4 family interacting protein 1 (Ndfip1) promotes death of pancreatic beta cells. Biochem Biophys Res Commun. 2015 Oct 02; 465(4):851-6. Beck A, Shatz-Azoulay H, Vinik Y, Isaac R, Boura-Halfon S, Zick Y. PMID: 26319551.
View in: PubMed Mentions: 3 Fields:
Translation:HumansAnimalsCells - Selective serotonin reuptake inhibitors (SSRIs) inhibit insulin secretion and action in pancreatic β cells. J Biol Chem. 2013 Feb 22; 288(8):5682-93. Isaac R, Boura-Halfon S, Gurevitch D, Shainskaya A, Levkovitz Y, Zick Y. PMID: 23275337; PMCID: PMC3581374.
View in: PubMed Mentions: 38 Fields:
Translation:HumansAnimalsCells - Elimination of negative feedback control mechanisms along the insulin signaling pathway improves beta-cell function under stress. Diabetes. 2010 Sep; 59(9):2188-97. Gurevitch D, Boura-Halfon S, Isaac R, Shahaf G, Alberstein M, Ronen D, Lewis EC, Zick Y. PMID: 20547979; PMCID: PMC2927941.
View in: PubMed Mentions: 7 Fields:
Translation:AnimalsCells
This graph shows the number and percent of publications by field. Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications. Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written. To see the data as text, click here.
This graph shows the number and percent of publications by field. Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications. Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written. To see the data as text, click here.
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