Kathy Ivey • UCSF Profiles (original) (raw)

  1. First-in-human study of TN-201, an AAV9 gene replacement therapy in MYBPC3-associated hypertrophic cardiomyopathy: initial safety, pharmacodynamic, and imaging results from MyPEAK-1. Cardiovasc Res. 2025 Dec 31; 121(17):2628-2631. Desai MY, Nagueh SF, Giudicessi JR, Previs MJ, Kellner D, Pollman MJ, Varfaj F, Robertson LA, Sonicheva-Paterson N, Pushkin R, Mangal B, Tomlinson L, Harrison WG, Yamamoto L, Argast G, Lombardi LM, Ivey KN, Tingley WG. PMID: 41206746; PMCID: PMC12754841.
    View in: PubMed Mentions: Fields:
    Translation:HumansCellsCTClinical Trials
  2. Maintenance of Energy Metabolism Is an Integral Part of Plakophilin-2 and Desmosome Functions. JACC Basic Transl Sci. 2025 Dec; 10(12):101428. Aycinena JA, Tefera AE, Perea-Gil I, Holbrook-Smith D, Williams K, Shenwai R, Farshidfar F, Ryback B, Foppe K, Wu I, Zeng A, Van Pell M, Xu E, Woods J, Jones S, Hatter Y, Dee-Hoskins C, Madariaga J, Robinson K, Greer-Short A, Song X, Ivey KN, Priest J, Argast G, Hoey T, Driggers E, Yang ZJ. PMID: 41432339; PMCID: PMC12861652.
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  3. AAV9-mediated MYBPC3 gene therapy with optimized expression cassette enhances cardiac function and survival in MYBPC3 cardiomyopathy models. Nat Commun. 2025 Mar 04; 16(1):2196. Greer-Short A, Greenwood A, Leon EC, Qureshi TN, von Kraut K, Wong J, Tsui JH, Reid CA, Cheng Z, Easter E, Yang J, Ho J, Steltzer S, Budan A, Cho M, Chandrakumar R, Cisne-Thompson O, Feathers C, Chung TW, Rodriguez N, Jones S, Alleyne-Levy C, Liu J, Jing F, Prince WS, Lin J, Ivey KN, Tingley WG, Hoey T, Lombardi LM. PMID: 40038304; PMCID: PMC11880196.
    View in: PubMed Mentions: 15 Fields:
    Translation:HumansAnimalsCells
  4. AAV9:PKP2 improves heart function and survival in a Pkp2-deficient mouse model of arrhythmogenic right ventricular cardiomyopathy. Commun Med (Lond). 2024 Mar 18; 4(1):38. Wu I, Zeng A, Greer-Short A, Aycinena JA, Tefera AE, Shenwai R, Farshidfar F, Van Pell M, Xu E, Reid C, Rodriguez N, Lim B, Chung TW, Woods J, Scott A, Jones S, Dee-Hoskins C, Gutierrez CG, Madariaga J, Robinson K, Hatter Y, Butler R, Steltzer S, Ho J, Priest JR, Song X, Jing F, Green K, Ivey KN, Hoey T, Yang J, Yang ZJ. PMID: 38499690; PMCID: PMC10948840.
    View in: PubMed Mentions: 28
  5. The multi-lineage transcription factor ISL1 controls cardiomyocyte cell fate through interaction with NKX2.5. Stem Cell Reports. 2023 11 14; 18(11):2138-2153. Maven BEJ, Gifford CA, Weilert M, Gonzalez-Teran B, Hüttenhain R, Pelonero A, Ivey KN, Samse-Knapp K, Kwong W, Gordon D, McGregor M, Nishino T, Okorie E, Rossman S, Costa MW, Krogan NJ, Zeitlinger J, Srivastava D. PMID: 37863045; PMCID: PMC10679653.
    View in: PubMed Mentions: 5 Fields:
    Translation:HumansCells
  6. Improved Cardiac Function in Postischemic Rats Using an Optimized Cardiac Reprogramming Cocktail Delivered in a Single Novel Adeno-Associated Virus. Circulation. 2023 10 03; 148(14):1099-1112. Zhou H, Yang J, Srinath C, Zeng A, Wu I, Leon EC, Qureshi TN, Reid CA, Nettesheim ER, Xu E, Duclos Z, Mohamed TMA, Farshidfar F, Fejes A, Liu J, Jones S, Feathers C, Chung TW, Jing F, Prince WS, Lin J, Yu P, Srivastava D, Hoey T, Ivey KN, Lombardi LM. PMID: 37602409.
    View in: PubMed Mentions: 7 Fields:
    Translation:HumansAnimalsCells
  7. Transient Cell Cycle Induction in Cardiomyocytes to Treat Subacute Ischemic Heart Failure. Circulation. 2022 04 26; 145(17):1339-1355. Abouleisa RRE, Salama ABM, Ou Q, Tang XL, Solanki M, Guo Y, Nong Y, McNally L, Lorkiewicz PK, Kassem KM, Ahern BM, Choudhary K, Thomas R, Huang Y, Juhardeen HR, Siddique A, Ifthikar Z, Hammad SK, Elbaz AS, Ivey KN, Conklin DJ, Satin J, Hill BG, Srivastava D, Bolli R, Mohamed TMA. PMID: 35061545; PMCID: PMC9038650.
    View in: PubMed Mentions: 35 Fields:
    Translation:HumansAnimalsCells
  8. Physiological Biomimetic Culture System for Pig and Human Heart Slices. Circ Res. 2019 08 30; 125(6):628-642. Ou Q, Jacobson Z, Abouleisa RRE, Tang XL, Hindi SM, Kumar A, Ivey KN, Giridharan G, El-Baz A, Brittian K, Rood B, Lin YH, Watson SA, Perbellini F, McKinsey TA, Hill BG, Jones SP, Terracciano CM, Bolli R, Mohamed TMA. PMID: 31310161; PMCID: PMC6715512.
    View in: PubMed Mentions: 52 Fields:
    Translation:HumansAnimalsCells
  9. Context-Specific Transcription Factor Functions Regulate Epigenomic and Transcriptional Dynamics during Cardiac Reprogramming. Cell Stem Cell. 2019 07 03; 25(1):87-102.e9. Stone NR, Gifford CA, Thomas R, Pratt KJB, Samse-Knapp K, Mohamed TMA, Radzinsky EM, Schricker A, Ye L, Yu P, van Bemmel JG, Ivey KN, Pollard KS, Srivastava D. PMID: 31271750; PMCID: PMC6632093.
    View in: PubMed Mentions: 74 Fields:
    Translation:AnimalsCells
  10. Oligogenic inheritance of a human heart disease involving a genetic modifier. Science. 2019 05 31; 364(6443):865-870. Gifford CA, Ranade SS, Samarakoon R, Salunga HT, de Soysa TY, Huang Y, Zhou P, Elfenbein A, Wyman SK, Bui YK, Cordes Metzler KR, Ursell P, Ivey KN, Srivastava D. PMID: 31147515; PMCID: PMC6557373.
    View in: PubMed Mentions: 111 Fields:
    Translation:HumansAnimalsCells
  11. The E3 ubiquitin ligase Nedd4/Nedd4L is directly regulated by microRNA 1. Development. 2017 03 01; 144(5):866-875. Zhu JY, Heidersbach A, Kathiriya IS, Garay BI, Ivey KN, Srivastava D, Han Z, King IN. PMID: 28246214; PMCID: PMC5374346.
    View in: PubMed Mentions: 13 Fields:
    Translation:AnimalsCells
  12. A Heart of Stone: Cardiac Fibroblasts Turn to Bone in Calcified Hearts. Cell Stem Cell. 2017 02 02; 20(2):151-152. Ivey KN. PMID: 28157494.
    View in: PubMed Mentions: 3 Fields:
    Translation:HumansCells
  13. Chemical Enhancement of In Vitro and In Vivo Direct Cardiac Reprogramming. Circulation. 2017 Mar 07; 135(10):978-995. Mohamed TM, Stone NR, Berry EC, Radzinsky E, Huang Y, Pratt K, Ang YS, Yu P, Wang H, Tang S, Magnitsky S, Ding S, Ivey KN, Srivastava D. PMID: 27834668; PMCID: PMC5340593.
    View in: PubMed Mentions: 133 Fields:
    Translation:HumansAnimalsCells
  14. Practical Integration-Free Episomal Methods for Generating Human Induced Pluripotent Stem Cells. Curr Protoc Hum Genet. 2015 Oct 06; 87:21.2.1-21.2.21. Kime C, Rand TA, Ivey KN, Srivastava D, Yamanaka S, Tomoda K. PMID: 26439714.
    View in: PubMed Mentions: 12 Fields:
    Translation:HumansCells
  15. microRNAs as Developmental Regulators. Cold Spring Harb Perspect Biol. 2015 Jul 01; 7(7):a008144. Ivey KN, Srivastava D. PMID: 26134312; PMCID: PMC4484971.
    View in: PubMed Mentions: 134 Fields:
    Translation:AnimalsCells
  16. NOTCH1 regulates matrix gla protein and calcification gene networks in human valve endothelium. J Mol Cell Cardiol. 2015 Jul; 84:13-23. White MP, Theodoris CV, Liu L, Collins WJ, Blue KW, Lee JH, Meng X, Robbins RC, Ivey KN, Srivastava D. PMID: 25871831; PMCID: PMC4468000.
    View in: PubMed Mentions: 33 Fields:
    Translation:HumansCells
  17. The RNA-binding protein TDP-43 selectively disrupts microRNA-1/206 incorporation into the RNA-induced silencing complex. J Biol Chem. 2014 May 16; 289(20):14263-71. King IN, Yartseva V, Salas D, Kumar A, Heidersbach A, Ando DM, Stallings NR, Elliott JL, Srivastava D, Ivey KN. PMID: 24719334; PMCID: PMC4022891.
    View in: PubMed Mentions: 46 Fields:
    Translation:HumansAnimalsCells
  18. microRNA-1 regulates sarcomere formation and suppresses smooth muscle gene expression in the mammalian heart. Elife. 2013 Nov 19; 2:e01323. Heidersbach A, Saxby C, Carver-Moore K, Huang Y, Ang YS, de Jong PJ, Ivey KN, Srivastava D. PMID: 24252873; PMCID: PMC3833424.
    View in: PubMed Mentions: 76 Fields:
    Translation:AnimalsCells
  19. Modeling human protein aggregation cardiomyopathy using murine induced pluripotent stem cells. Stem Cells Transl Med. 2013 Mar; 2(3):161-6. Limphong P, Zhang H, Christians E, Liu Q, Riedel M, Ivey K, Cheng P, Mitzelfelt K, Taylor G, Winge D, Srivastava D, Benjamin I. PMID: 23430692; PMCID: PMC3659767.
    View in: PubMed Mentions: 3 Fields:
    Translation:HumansAnimalsCells
  20. Limited gene expression variation in human embryonic stem cell and induced pluripotent stem cell-derived endothelial cells. Stem Cells. 2013 Jan; 31(1):92-103. White MP, Rufaihah AJ, Liu L, Ghebremariam YT, Ivey KN, Cooke JP, Srivastava D. PMID: 23079999; PMCID: PMC3528812.
    View in: PubMed Mentions: 67 Fields:
    Translation:HumansCells
  21. MicroRNA-10 regulates the angiogenic behavior of zebrafish and human endothelial cells by promoting vascular endothelial growth factor signaling. Circ Res. 2012 Nov 09; 111(11):1421-33. Hassel D, Cheng P, White MP, Ivey KN, Kroll J, Augustin HG, Katus HA, Stainier DY, Srivastava D. PMID: 22955733; PMCID: PMC3525481.
    View in: PubMed Mentions: 43 Fields:
    Translation:HumansAnimalsCells
  22. Hand2 function in second heart field progenitors is essential for cardiogenesis. Dev Biol. 2011 Mar 01; 351(1):62-9. Tsuchihashi T, Maeda J, Shin CH, Ivey KN, Black BL, Olson EN, Yamagishi H, Srivastava D. PMID: 21185281; PMCID: PMC3039109.
    View in: PubMed Mentions: 65 Fields:
    Translation:AnimalsCells
  23. The neural crest-enriched microRNA miR-452 regulates epithelial-mesenchymal signaling in the first pharyngeal arch. Development. 2010 Dec; 137(24):4307-16. Sheehy NT, Cordes KR, White MP, Ivey KN, Srivastava D. PMID: 21098571; PMCID: PMC2990216.
    View in: PubMed Mentions: 37 Fields:
    Translation:AnimalsCells
  24. skNAC, a Smyd1-interacting transcription factor, is involved in cardiac development and skeletal muscle growth and regeneration. Proc Natl Acad Sci U S A. 2010 Nov 30; 107(48):20750-5. Park CY, Pierce SA, von Drehle M, Ivey KN, Morgan JA, Blau HM, Srivastava D. PMID: 21071677; PMCID: PMC2996447.
    View in: PubMed Mentions: 52 Fields:
    Translation:AnimalsCells
  25. MicroRNAs as regulators of differentiation and cell fate decisions. Cell Stem Cell. 2010 Jul 02; 7(1):36-41. Ivey KN, Srivastava D. PMID: 20621048.
    View in: PubMed Mentions: 247 Fields:
    Translation:HumansAnimalsCells
  26. MicroRNAs in cardiac development. Pediatr Cardiol. 2010 Apr; 31(3):349-56. Cordes KR, Srivastava D, Ivey KN. PMID: 20140609; PMCID: PMC2836460.
    View in: PubMed Mentions: 28 Fields:
    Translation:HumansCells
  27. miR-145 and miR-143 regulate smooth muscle cell fate and plasticity. Nature. 2009 Aug 06; 460(7256):705-10. Cordes KR, Sheehy NT, White MP, Berry EC, Morton SU, Muth AN, Lee TH, Miano JM, Ivey KN, Srivastava D. PMID: 19578358; PMCID: PMC2769203.
    View in: PubMed Mentions: 826 Fields:
    Translation:AnimalsCells
  28. Cardiac fibroblasts regulate myocardial proliferation through beta1 integrin signaling. Dev Cell. 2009 Feb; 16(2):233-44. Ieda M, Tsuchihashi T, Ivey KN, Ross RS, Hong TT, Shaw RM, Srivastava D. PMID: 19217425; PMCID: PMC2664087.
    View in: PubMed Mentions: 306 Fields:
    Translation:AnimalsCells
  29. Serum response factor orchestrates nascent sarcomerogenesis and silences the biomineralization gene program in the heart. Proc Natl Acad Sci U S A. 2008 Nov 18; 105(46):17824-9. Niu Z, Iyer D, Conway SJ, Martin JF, Ivey K, Srivastava D, Nordheim A, Schwartz RJ. PMID: 19004760; PMCID: PMC2584699.
    View in: PubMed Mentions: 70 Fields:
    Translation:AnimalsCells
  30. microRNA-138 modulates cardiac patterning during embryonic development. Proc Natl Acad Sci U S A. 2008 Nov 18; 105(46):17830-5. Morton SU, Scherz PJ, Cordes KR, Ivey KN, Stainier DY, Srivastava D. PMID: 19004786; PMCID: PMC2582580.
    View in: PubMed Mentions: 95 Fields:
    Translation:AnimalsCells
  31. miR-126 regulates angiogenic signaling and vascular integrity. Dev Cell. 2008 Aug; 15(2):272-84. Fish JE, Santoro MM, Morton SU, Yu S, Yeh RF, Wythe JD, Ivey KN, Bruneau BG, Stainier DY, Srivastava D. PMID: 18694566; PMCID: PMC2604134.
    View in: PubMed Mentions: 847 Fields:
    Translation:HumansAnimalsCells
  32. Transcriptional regulation during development of the ductus arteriosus. Circ Res. 2008 Aug 15; 103(4):388-95. Ivey KN, Sutcliffe D, Richardson J, Clyman RI, Garcia JA, Srivastava D. PMID: 18635823; PMCID: PMC2645272.
    View in: PubMed Mentions: 29 Fields:
  33. MicroRNA regulation of cell lineages in mouse and human embryonic stem cells. Cell Stem Cell. 2008 Mar 06; 2(3):219-29. Ivey KN, Muth A, Arnold J, King FW, Yeh RF, Fish JE, Hsiao EC, Schwartz RJ, Conklin BR, Bernstein HS, Srivastava D. PMID: 18371447; PMCID: PMC2293325.
    View in: PubMed Mentions: 285 Fields:
    Translation:HumansAnimalsCells
  34. The paradoxical patent ductus arteriosus. J Clin Invest. 2006 Nov; 116(11):2863-5. Ivey KN, Srivastava D. PMID: 17080192; PMCID: PMC1626120.
    View in: PubMed Mentions: 13 Fields:
    Translation:HumansAnimalsCells
  35. Potential of stem-cell-based therapies for heart disease. Nature. 2006 Jun 29; 441(7097):1097-9. Srivastava D, Ivey KN. PMID: 16810246.
    View in: PubMed Mentions: 53 Fields:
    Translation:HumansAnimalsCells
  36. Sonic hedgehog is essential for first pharyngeal arch development. Pediatr Res. 2006 Mar; 59(3):349-54. Yamagishi C, Yamagishi H, Maeda J, Tsuchihashi T, Ivey K, Hu T, Srivastava D. PMID: 16492970.
    View in: PubMed Mentions: 20 Fields:
    Translation:HumansAnimalsCells
  37. Galphaq and Galpha11 proteins mediate endothelin-1 signaling in neural crest-derived pharyngeal arch mesenchyme. Dev Biol. 2003 Mar 15; 255(2):230-7. Ivey K, Tyson B, Ukidwe P, McFadden DG, Levi G, Olson EN, Srivastava D, Wilkie TM. PMID: 12648486.
    View in: PubMed Mentions: 22 Fields:
    Translation:AnimalsCells
  38. A common cis-acting sequence in the DiGeorge critical region regulates bi-directional transcription of UFD1L and CDC45L. Mech Dev. 2001 Oct; 108(1-2):81-92. Kunte A, Ivey K, Yamagishi C, Garg V, Yamagishi H, Srivastava D. PMID: 11578863.
    View in: PubMed Mentions: 3 Fields:
    Translation:HumansAnimalsCells
  39. shl, a New set of Arabidopsis mutants with exaggerated developmental responses to available red, far-red, and blue light. Plant Physiol. 2001 Sep; 127(1):295-304. Pepper AE, Seong-Kim M, Hebst SM, Ivey KN, Kwak SJ, Broyles DE. PMID: 11553757; PMCID: PMC117985.
    View in: PubMed Mentions: 6 Fields:
    Translation:AnimalsCells
  40. Cell surface monkey CD9 antigen is a coreceptor that increases diphtheria toxin sensitivity and diphtheria toxin receptor affinity. J Biol Chem. 2000 Mar 10; 275(10):6901-7. Cha JH, Brooke JS, Ivey KN, Eidels L. PMID: 10702250.
    View in: PubMed Mentions: 11 Fields:
    Translation:AnimalsCells

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