Wenhan Chang • UCSF Profiles (original) (raw)

  1. The emerging role of integrin signaling in pulmonary vascular disease. Am J Physiol Lung Cell Mol Physiol. 2026 Mar 18. Bai AS, Sørensen GL, Sundaram AB, Chang W, Tuder RM, Graham BB, Lee MH. PMID: 41849225.
    View in: PubMed Mentions:
  2. Amyloid-ß as a target to suppress tonic PTH hypersecretion in hyperparathyroidism due to vitamin D deficiency. Sci Transl Med. 2026 Mar 18; 18(841):eadz2837. Tu CL, Cheng Z, Szeto N, Savransky S, Glinin T, Herberger A, Shoback DM, Sosa JA, Vilardaga JP, Koh J, Chang W. PMID: 41849578.
    View in: PubMed Mentions:
  3. Transcriptional and neuroprotective effects of hexokinase-2 inhibitors administered after stroke. J Neuroinflammation. 2025 Oct 28; 22(1):247. Won SJ, Uruk G, Mai N, Tu CL, Ogut D, Asatryan S, Mocanu E, Shon R, Kim K, Awakoaiye K, Arkelius K, Chang W, Singhal NS, Swanson RA. PMID: 41152941; PMCID: PMC12570821.
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  4. Deletion of cardiac fibroblast growth factor-23 beneficially impacts myocardial energy metabolism in left ventricular hypertrophy. NPJ Metab Health Dis. 2025 Oct 28; 3(1):42. Latic N, Lari A, Sun N, Zupcic A, Oubounyt M, Falivene J, Buck A, Hofer M, Chang W, Kuebler WM, Baumbach J, Walch AK, Grabner A, Erben RG. PMID: 41152461; PMCID: PMC12569085.
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  5. Hypertension promotes bone loss and fragility by favoring bone resorption in mouse models. J Clin Invest. 2025 Oct 15; 135(20). Hennen EM, Uppuganti S, de la Visitación N, Chen W, Krishnan J, Vecchi LA, Patrick DM, Siedlinski M, Lemoli M, Delgado R, de Caestecker MP, Chang W, Guzik TJ, Johnson RW, Harrison DG, Nyman JS. PMID: 40828611; PMCID: PMC12547992.
    View in: PubMed Mentions: Fields:
  6. β-Amyloid as a new target to suppress tonic PTH hypersecretion in primary hyperparathyroidism. medRxiv. 2025 May 28. Tu CL, Cheng Z, Szeto N, Savransky S, Glinin T, Shoback DM, Sosa JA, Vilardaga JP, Koh J, Chang W. PMID: 40492090; PMCID: PMC12148266.
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  7. Extracellular Ca2+-Sensing Receptor (CaSR) Regulates Hypothalamic Function to Control Energy and Skeletal Metabolism in Mice. bioRxiv. 2025 May 27. Park-Sigal J, Norton M, Tu CL, Cheng Z, Fadahunsi N, Lee H, Kim S, Li A, Grinberg LT, Bewick GA, Murphy KG, Chang W. PMID: 40501942; PMCID: PMC12154921.
    View in: PubMed Mentions:
  8. Targeted Deletion of Fibroblast Growth Factor 23 Rescues Metabolic Dysregulation of Diet-induced Obesity in Female Mice. Endocrinology. 2024 Oct 30; 165(12). Park MY, Tu CL, Perie L, Verma N, Serdan TDA, Shamsi F, Shapses S, Heffron S, Gamallo-Lana B, Mar AC, Alemán JO, Mueller E, Chang W, Sitara D. PMID: 39446375; PMCID: PMC11538792.
    View in: PubMed Mentions:
  9. Large library docking identifies positive allosteric modulators of the calcium-sensing receptor. Science. 2024 09 20; 385(6715):eado1868. Liu F, Wu CG, Tu CL, Glenn I, Meyerowitz J, Kaplan AL, Lyu J, Cheng Z, Tarkhanova OO, Moroz YS, Irwin JJ, Chang W, Shoichet BK, Skiniotis G. PMID: 39298584; PMCID: PMC11629082.
    View in: PubMed Mentions: 11 Fields:
    Translation:HumansAnimalsCells
  10. The osteocytic actions of glucocorticoids on bone mass, mechanical properties, or perilacunar remodeling outcomes are not rescued by PTH(1-34). Front Endocrinol (Lausanne). 2024; 15:1342938. Yee CS, Meliadis C, Kaya S, Chang W, Alliston T. PMID: 39092287; PMCID: PMC11291448.
    View in: PubMed Mentions: Fields:
    Translation:AnimalsCells
  11. Linoleic acid blunts early osteoblast differentiation and impairs oxidative phosphorylation in vitro. Prostaglandins Leukot Essent Fatty Acids. 2024 Feb; 201:102617. Nesbeth PC, Ziegler TR, Tripathi AK, Dabeer S, Weiss D, Hao L, Smith MR, Jones DP, Maner-Smith KM, Tu CL, Chang W, Weitzmann MN, Alvarez JA. PMID: 38788347; PMCID: PMC11293625.
    View in: PubMed Mentions: 2 Fields:
    Translation:AnimalsCells
  12. Calcium/calcimimetic via calcium-sensing receptor ameliorates cholera toxin-induced secretory diarrhea in mice. World J Gastroenterol. 2024 Jan 21; 30(3):268-279. Tang LQ, Fraebel J, Jin S, Winesett SP, Harrell J, Chang WH, Cheng SX. PMID: 38314127; PMCID: PMC10835527.
    View in: PubMed Mentions: 2 Fields:
    Translation:Animals
  13. FGF23 directly inhibits osteoprogenitor differentiation in Dmp1-knockout mice. JCI Insight. 2023 12 22; 8(24). Courbon G, Kentrup D, Thomas JJ, Wang X, Tsai HH, Spindler J, Von Drasek J, Ndjonko LM, Martinez-Calle M, Lynch S, Hivert L, Wang X, Chang W, Feng JQ, David V, Martin A. PMID: 37943605; PMCID: PMC10807721.
    View in: PubMed Mentions: 6 Fields:
    Translation:Animals
  14. Bone-derived C-terminal FGF23 cleaved peptides increase iron availability in acute inflammation. Blood. 2023 07 06; 142(1):106-118. Courbon G, Thomas JJ, Martinez-Calle M, Wang X, Spindler J, Von Drasek J, Hunt-Tobey B, Mehta R, Isakova T, Chang W, Creemers JWM, Ji P, Martin A, David V. PMID: 37053547; PMCID: PMC10356820.
    View in: PubMed Mentions: 24 Fields:
    Translation:Animals
  15. Digital spatial profiling of human parathyroid tumors reveals cellular and molecular alterations linked to vitamin D deficiency. PNAS Nexus. 2023 Mar; 2(3):pgad073. Tu CL, Chang W, Sosa JA, Koh J. PMID: 36992820; PMCID: PMC10042281.
    View in: PubMed Mentions: 1
  16. Hyperaminoacidemia induces pancreatic a cell proliferation via synergism between the mTORC1 and CaSR-Gq signaling pathways. Nat Commun. 2023 Jan 16; 14(1):235. Gong Y, Yang B, Zhang D, Zhang Y, Tang Z, Yang L, Coate KC, Yin L, Covington BA, Patel RS, Siv WA, Sellick K, Shou M, Chang W, Danielle Dean E, Powers AC, Chen W. PMID: 36646689; PMCID: PMC9842633.
    View in: PubMed Mentions: 8 Fields:
    Translation:AnimalsCells
  17. Immune Reconstitution Bone Loss Exacerbates Bone Degeneration Due to Natural Aging in a Mouse Model. J Infect Dis. 2022 08 12; 226(1):38-48. Weitzmann MN, Weiss D, Vikulina T, Roser-Page S, Yu K, McGee-Lawrence ME, Tu CL, Chang W, Ofotokun I. PMID: 34962571; PMCID: PMC9373144.
    View in: PubMed Mentions: 6 Fields:
    Translation:HumansAnimalsCells
  18. Impaired Mineral Ion Metabolism in a Mouse Model of Targeted Calcium-Sensing Receptor (CaSR) Deletion from Vascular Smooth Muscle Cells. J Am Soc Nephrol. 2022 07; 33(7):1323-1340. Schepelmann M, Ranieri M, Lopez-Fernandez I, Webberley TS, Brennan SC, Yarova PL, Graca J, Hanif UK, Müller C, Manhardt T, Salzmann M, Quasnichka H, Price SA, Ward DT, Gilbert T, Matchkov VV, Fenton RA, Herberger A, Hwong J, Santa Maria C, Tu CL, Kallay E, Valenti G, Chang W, Riccardi D. PMID: 35581010; PMCID: PMC9257819.
    View in: PubMed Mentions: 10 Fields:
    Translation:AnimalsCells
  19. Precise druggability of the PTH type 1 receptor. Nat Chem Biol. 2022 03; 18(3):272-280. Sutkeviciute I, Lee JY, White AD, Maria CS, Peña KA, Savransky S, Doruker P, Li H, Lei S, Kaynak B, Tu C, Clark LJ, Sanker S, Gardella TJ, Chang W, Bahar I, Vilardaga JP. PMID: 34949836; PMCID: PMC8891041.
    View in: PubMed Mentions: 14 Fields:
    Translation:Cells
  20. Spatial bias in cAMP generation determines biological responses to PTH type 1 receptor activation. Sci Signal. 2021 Oct 05; 14(703):eabc5944. White AD, Peña KA, Clark LJ, Maria CS, Liu S, Jean-Alphonse FG, Lee JY, Lei S, Cheng Z, Tu CL, Fang F, Szeto N, Gardella TJ, Xiao K, Gellman SH, Bahar I, Sutkeviciute I, Chang W, Vilardaga JP. PMID: 34609896; PMCID: PMC8682804.
    View in: PubMed Mentions: 36 Fields:
  21. FBW7 couples structural integrity with functional output of primary cilia. Commun Biol. 2021 09 13; 4(1):1066. Petsouki E, Gerakopoulos V, Szeto N, Chang W, Humphrey MB, Tsiokas L. PMID: 34518642; PMCID: PMC8438042.
    View in: PubMed Mentions: 5 Translation:AnimalsCells
  22. The mTORC2 Regulator Homer1 Modulates Protein Levels and Sub-Cellular Localization of the CaSR in Osteoblast-Lineage Cells. Int J Mol Sci. 2021 Jun 17; 22(12). Rybchyn MS, Brennan-Speranza TC, Mor D, Cheng Z, Chang W, Conigrave AD, Mason RS. PMID: 34204449; PMCID: PMC8234890.
    View in: PubMed Mentions: 6 Fields:
    Translation:HumansAnimalsCells
  23. Enhanced excitability of cortical neurons in low-divalent solutions is primarily mediated by altered voltage-dependence of voltage-gated sodium channels. Elife. 2021 05 11; 10. Martiszus BJ, Tsintsadze T, Chang W, Smith SM. PMID: 33973519; PMCID: PMC8163501.
    View in: PubMed Mentions: 19 Fields:
    Translation:AnimalsCells
  24. Calcium-sensing receptor and CPAP-induced neonatal airway hyperreactivity in mice. Pediatr Res. 2022 05; 91(6):1391-1398. Mayer CA, Roos B, Teske J, Wells N, Martin RJ, Chang W, Pabelick CM, Prakash YS, MacFarlane PM. PMID: 33958714; PMCID: PMC8571113.
    View in: PubMed Mentions: 6 Fields:
    Translation:HumansAnimals
  25. Renal Dnase1 expression is regulated by FGF23 but loss of Dnase1 does not alter renal phosphate handling. Sci Rep. 2021 03 17; 11(1):6175. Egli-Spichtig D, Zhang MYH, Li A, Pastor Arroyo EM, Hernando N, Wagner CA, Chang W, Perwad F. PMID: 33731726; PMCID: PMC7969776.
    View in: PubMed Mentions: 1 Fields:
    Translation:Animals
  26. Calcium-sensing receptor-mediated NLRP3 inflammasome response to calciprotein particles drives inflammation in rheumatoid arthritis. Nat Commun. 2020 08 25; 11(1):4243. Jäger E, Murthy S, Schmidt C, Hahn M, Strobel S, Peters A, Stäubert C, Sungur P, Venus T, Geisler M, Radusheva V, Raps S, Rothe K, Scholz R, Jung S, Wagner S, Pierer M, Seifert O, Chang W, Estrela-Lopis I, Raulien N, Krohn K, Sträter N, Hoeppener S, Schöneberg T, Rossol M, Wagner U. PMID: 32843625; PMCID: PMC7447633.
    View in: PubMed Mentions: 75 Fields:
    Translation:HumansAnimalsCells
  27. Control of PTH secretion by the TRPC1 ion channel. JCI Insight. 2020 04 23; 5(8). Onopiuk M, Eby B, Nesin V, Ngo P, Lerner M, Gorvin CM, Stokes VJ, Thakker RV, Brandi ML, Chang W, Humphrey MB, Tsiokas L, Lau K. PMID: 32213715; PMCID: PMC7205425.
    View in: PubMed Mentions: 7 Fields:
    Translation:HumansAnimalsCells
  28. PTH hypersecretion triggered by a GABAB1 and Ca2+-sensing receptor heterocomplex in hyperparathyroidism. Nat Metab. 2020 03; 2(3):243-255. Chang W, Tu CL, Jean-Alphonse FG, Herberger A, Cheng Z, Hwong J, Ho H, Li A, Wang D, Liu H, White AD, Suh I, Shen W, Duh QY, Khanafshar E, Shoback DM, Xiao K, Vilardaga JP. PMID: 32694772; PMCID: PMC7377265.
    View in: PubMed Mentions: 19 Fields:
    Translation:HumansAnimals
  29. Glycerol-3-phosphate is an FGF23 regulator derived from the injured kidney. J Clin Invest. 2020 03 02; 130(3):1513-1526. Simic P, Kim W, Zhou W, Pierce KA, Chang W, Sykes DB, Aziz NB, Elmariah S, Ngo D, Pajevic PD, Govea N, Kestenbaum BR, de Boer IH, Cheng Z, Christov M, Chun J, Leaf DE, Waikar SS, Tager AM, Gerszten RE, Thadhani RI, Clish CB, Jüppner H, Wein MN, Rhee EP. PMID: 32065590; PMCID: PMC7269595.
    View in: PubMed Mentions: 68 Fields:
    Translation:HumansAnimalsCells
  30. Calcium-Sensing Receptors in Chondrocytes and Osteoblasts Are Required for Callus Maturation and Fracture Healing in Mice. J Bone Miner Res. 2020 01; 35(1):143-154. Cheng Z, Li A, Tu CL, Maria CS, Szeto N, Herberger A, Chen TH, Song F, Wang J, Liu X, Shoback DM, Chang W. PMID: 31498905; PMCID: PMC7700777.
    View in: PubMed Mentions: 18 Fields:
    Translation:AnimalsCells
  31. Phosphate acts directly on the calcium-sensing receptor to stimulate parathyroid hormone secretion. Nat Commun. 2019 10 16; 10(1):4693. Centeno PP, Herberger A, Mun HC, Tu C, Nemeth EF, Chang W, Conigrave AD, Ward DT. PMID: 31619668; PMCID: PMC6795806.
    View in: PubMed Mentions: 107 Fields:
    Translation:HumansAnimalsCells
  32. Homer1 mediates CaSR-dependent activation of mTOR complex 2 and initiates a novel pathway for AKT-dependent β-catenin stabilization in osteoblasts. J Biol Chem. 2019 11 01; 294(44):16337-16350. Rybchyn MS, Islam KS, Brennan-Speranza TC, Cheng Z, Brennan SC, Chang W, Mason RS, Conigrave AD. PMID: 31527082; PMCID: PMC6827303.
    View in: PubMed Mentions: 17 Fields:
    Translation:HumansAnimalsCells
  33. Myosin 1a Regulates Osteoblast Differentiation Independent of Intestinal Calcium Transport. J Endocr Soc. 2019 Nov 01; 3(11):1993-2011. Munson S, Wang Y, Chang W, Bikle DD. PMID: 31620669; PMCID: PMC6789431.
    View in: PubMed Mentions: 5
  34. Prevention of Injury-Induced Osteoarthritis in Rodent Temporomandibular Joint by Targeting Chondrocyte CaSR. J Bone Miner Res. 2019 04; 34(4):726-738. Zhang M, Yang H, Wan X, Lu L, Zhang J, Zhang H, Ye T, Liu Q, Xie M, Liu X, Yu S, Guo S, Chang W, Wang M. PMID: 30496623; PMCID: PMC6482062.
    View in: PubMed Mentions: 20 Fields:
    Translation:AnimalsCells
  35. The calcium-sensing receptor in physiology and in calcitropic and noncalcitropic diseases. Nat Rev Endocrinol. 2018 12; 15(1):33-51. Hannan FM, Kallay E, Chang W, Brandi ML, Thakker RV. PMID: 30443043; PMCID: PMC6535143.
    View in: PubMed Mentions: 171 Fields:
    Translation:Humans
  36. Calcium-Sensing Receptor Regulates Epidermal Intracellular Ca2+ Signaling and Re-Epithelialization after Wounding. J Invest Dermatol. 2019 04; 139(4):919-929. Tu CL, Celli A, Mauro T, Chang W. PMID: 30404020; PMCID: PMC6431556.
    View in: PubMed Mentions: 25 Fields:
    Translation:HumansAnimalsCells
  37. Calcimimetic R568 inhibits tetrodotoxin-sensitive colonic electrolyte secretion and reduces c-fos expression in myenteric neurons. Life Sci. 2018 Feb 01; 194:49-58. Sun X, Tang L, Winesett S, Chang W, Cheng SX. PMID: 29247746; PMCID: PMC5794538.
    View in: PubMed Mentions: 6 Fields:
    Translation:AnimalsCells
  38. Cartilage to bone transformation during fracture healing is coordinated by the invading vasculature and induction of the core pluripotency genes. Development. 2017 01 15; 144(2):221-234. Hu DP, Ferro F, Yang F, Taylor AJ, Chang W, Miclau T, Marcucio RS, Bahney CS. PMID: 28096214; PMCID: PMC5394763.
    View in: PubMed Mentions: 134 Fields:
    Translation:HumansAnimalsCells
  39. Calcium-Sensing Receptor Promotes Breast Cancer by Stimulating Intracrine Actions of Parathyroid Hormone-Related Protein. Cancer Res. 2016 09 15; 76(18):5348-60. Kim W, Takyar FM, Swan K, Jeong J, VanHouten J, Sullivan C, Dann P, Yu H, Fiaschi-Taesch N, Chang W, Wysolmerski J. PMID: 27450451; PMCID: PMC5026591.
    View in: PubMed Mentions: 33 Fields:
    Translation:HumansAnimals
  40. Sprouty2 regulates endochondral bone formation by modulation of RTK and BMP signaling. Bone. 2016 07; 88:170-179. Joo A, Long R, Cheng Z, Alexander C, Chang W, Klein OD. PMID: 27130872; PMCID: PMC4899137.
    View in: PubMed Mentions: 8 Fields:
    Translation:AnimalsCells
  41. Calcium Sensing Receptor Function Supports Osteoblast Survival and Acts as a Co-Factor in PTH Anabolic Actions in Bone. J Cell Biochem. 2016 07; 117(7):1556-67. Al-Dujaili SA, Koh AJ, Dang M, Mi X, Chang W, Ma PX, McCauley LK. PMID: 26579618; PMCID: PMC4856537.
    View in: PubMed Mentions: 19 Fields:
    Translation:AnimalsCells
  42. Unilateral anterior crossbite induces aberrant mineral deposition in degenerative temporomandibular cartilage in rats. Osteoarthritis Cartilage. 2016 May; 24(5):921-31. Zhang M, Wang H, Zhang J, Zhang H, Yang H, Wan X, Jing L, Lu L, Liu X, Yu S, Chang W, Wang M. PMID: 26746151; PMCID: PMC5699887.
    View in: PubMed Mentions: 31 Fields:
    Translation:AnimalsCells
  43. Interplay between CaSR and PTH1R signaling in skeletal development and osteoanabolism. Semin Cell Dev Biol. 2016 Jan; 49:11-23. Santa Maria C, Cheng Z, Li A, Wang J, Shoback D, Tu CL, Chang W. PMID: 26688334; PMCID: PMC4761456.
    View in: PubMed Mentions: 27 Fields:
    Translation:HumansAnimalsCells
  44. Comparative expression of the extracellular calcium-sensing receptor in the mouse, rat, and human kidney. Am J Physiol Renal Physiol. 2016 Mar 15; 310(6):F518-33. Graca JA, Schepelmann M, Brennan SC, Reens J, Chang W, Yan P, Toka H, Riccardi D, Price SA. PMID: 26661650; PMCID: PMC5005276.
    View in: PubMed Mentions: 26 Fields:
    Translation:HumansAnimals
  45. The vascular Ca2+-sensing receptor regulates blood vessel tone and blood pressure. Am J Physiol Cell Physiol. 2016 Feb 01; 310(3):C193-204. Schepelmann M, Yarova PL, Lopez-Fernandez I, Davies TS, Brennan SC, Edwards PJ, Aggarwal A, Graça J, Rietdorf K, Matchkov V, Fenton RA, Chang W, Krssak M, Stewart A, Broadley KJ, Ward DT, Price SA, Edwards DH, Kemp PJ, Riccardi D. PMID: 26538090; PMCID: PMC5243220.
    View in: PubMed Mentions: 48 Fields:
    Translation:AnimalsCells
  46. Role of IGF-I signaling in muscle bone interactions. Bone. 2015 Nov; 80:79-88. Bikle DD, Tahimic C, Chang W, Wang Y, Philippou A, Barton ER. PMID: 26453498; PMCID: PMC4600536.
    View in: PubMed Mentions: 80 Fields:
    Translation:HumansAnimalsCells
  47. Osteoblast-Specific Loss of IGF1R Signaling Results in Impaired Endochondral Bone Formation During Fracture Healing. J Bone Miner Res. 2015 Sep; 30(9):1572-84. Wang T, Wang Y, Menendez A, Fong C, Babey M, Tahimic CG, Cheng Z, Li A, Chang W, Bikle DD. PMID: 25801198; PMCID: PMC5690481.
    View in: PubMed Mentions: 37 Fields:
    Translation:AnimalsCells
  48. Calcium-sensing receptor antagonists abrogate airway hyperresponsiveness and inflammation in allergic asthma. Sci Transl Med. 2015 Apr 22; 7(284):284ra60. Yarova PL, Stewart AL, Sathish V, Britt RD, Thompson MA, P Lowe AP, Freeman M, Aravamudan B, Kita H, Brennan SC, Schepelmann M, Davies T, Yung S, Cholisoh Z, Kidd EJ, Ford WR, Broadley KJ, Rietdorf K, Chang W, Bin Khayat ME, Ward DT, Corrigan CJ, T Ward JP, Kemp PJ, Pabelick CM, Prakash YS, Riccardi D. PMID: 25904744; PMCID: PMC4725057.
    View in: PubMed Mentions: 80 Fields:
    Translation:HumansAnimalsCells
  49. Calcium-sensing receptor stimulates Cl(-)- and SCFA-dependent but inhibits cAMP-dependent HCO3(-) secretion in colon. Am J Physiol Gastrointest Liver Physiol. 2015 May 15; 308(10):G874-83. Tang L, Peng M, Liu L, Chang W, Binder HJ, Cheng SX. PMID: 25792563; PMCID: PMC4437021.
    View in: PubMed Mentions: 23 Fields:
    Translation:AnimalsCells
  50. The calcium-sensing receptor suppresses epithelial-to-mesenchymal transition and stem cell- like phenotype in the colon. Mol Cancer. 2015 Mar 18; 14:61. Aggarwal A, Prinz-Wohlgenannt M, Gröschel C, Tennakoon S, Meshcheryakova A, Chang W, Brown EM, Mechtcheriakova D, Kállay E. PMID: 25879211; PMCID: PMC4405849.
    View in: PubMed Mentions: 18 Fields:
    Translation:HumansAnimalsCells
  51. Wnt5a/Ror2 mediates temporomandibular joint subchondral bone remodeling. J Dent Res. 2015 Jun; 94(6):803-12. Yang T, Zhang J, Cao Y, Zhang M, Jing L, Jiao K, Yu S, Chang W, Chen D, Wang M. PMID: 25749876; PMCID: PMC6728679.
    View in: PubMed Mentions: 30 Fields:
    Translation:AnimalsCells
  52. Calcium-sensing receptor (CaSR) as a novel target for ischemic neuroprotection. Ann Clin Transl Neurol. 2014 Nov; 1(11):851-66. Kim JY, Ho H, Kim N, Liu J, Tu CL, Yenari MA, Chang W. PMID: 25540800; PMCID: PMC4265057.
    View in: PubMed Mentions: 29 Fields:
  53. Ephrin B2/EphB4 mediates the actions of IGF-I signaling in regulating endochondral bone formation. J Bone Miner Res. 2014 Aug; 29(8):1900-13. Wang Y, Menendez A, Fong C, ElAlieh HZ, Chang W, Bikle DD. PMID: 24677183; PMCID: PMC4108521.
    View in: PubMed Mentions: 34 Fields:
    Translation:AnimalsCells
  54. Disrupted bone remodeling leads to cochlear overgrowth and hearing loss in a mouse model of fibrous dysplasia. PLoS One. 2014; 9(5):e94989. Akil O, Hall-Glenn F, Chang J, Li A, Chang W, Lustig LR, Alliston T, Hsiao EC. PMID: 24788917; PMCID: PMC4006800.
    View in: PubMed Mentions: 8 Fields:
    Translation:AnimalsCells
  55. Joint instability and cartilage compression in a mouse model of posttraumatic osteoarthritis. J Orthop Res. 2014 Feb; 32(2):318-23. Onur TS, Wu R, Chu S, Chang W, Kim HT, Dang AB. PMID: 24167068; PMCID: PMC4462343.
    View in: PubMed Mentions: 24 Fields:
    Translation:Animals
  56. Autocrine and Paracrine Actions of IGF-I Signaling in Skeletal Development. Bone Res. 2013 Sep; 1(3):249-59. Wang Y, Bikle DD, Chang W. PMID: 26273506; PMCID: PMC4472106.
    View in: PubMed Mentions: 40 Fields:
  57. Hypothermia and pharmacological regimens that prevent overexpression and overactivity of the extracellular calcium-sensing receptor protect neurons against traumatic brain injury. J Neurotrauma. 2013 Jul 01; 30(13):1170-6. Kim JY, Kim N, Yenari MA, Chang W. PMID: 23360235; PMCID: PMC3700438.
    View in: PubMed Mentions: 11 Fields:
    Translation:AnimalsCells
  58. Mammary-specific ablation of the calcium-sensing receptor during lactation alters maternal calcium metabolism, milk calcium transport, and neonatal calcium accrual. Endocrinology. 2013 Sep; 154(9):3031-42. Mamillapalli R, VanHouten J, Dann P, Bikle D, Chang W, Brown E, Wysolmerski J. PMID: 23782944; PMCID: PMC3749485.
    View in: PubMed Mentions: 25 Fields:
    Translation:Animals
  59. Sex and age modify biochemical and skeletal manifestations of chronic hyperparathyroidism by altering target organ responses to Ca2+ and parathyroid hormone in mice. J Bone Miner Res. 2013 May; 28(5):1087-100. Cheng Z, Liang N, Chen TH, Li A, Santa Maria C, You M, Ho H, Song F, Bikle D, Tu C, Shoback D, Chang W. PMID: 23239173; PMCID: PMC3617088.
    View in: PubMed Mentions: 17 Fields:
    Translation:Animals
  60. The extracellular calcium-sensing receptor, CaSR, in fetal development. Best Pract Res Clin Endocrinol Metab. 2013 Jun; 27(3):443-53. Riccardi D, Brennan SC, Chang W. PMID: 23856271; PMCID: PMC4462341.
    View in: PubMed Mentions: 21 Fields:
    Translation:HumansAnimalsCells
  61. Ablation of the calcium-sensing receptor in keratinocytes impairs epidermal differentiation and barrier function. J Invest Dermatol. 2012 Oct; 132(10):2350-2359. Tu CL, Crumrine DA, Man MQ, Chang W, Elalieh H, You M, Elias PM, Bikle DD. PMID: 22622426; PMCID: PMC3434298.
    View in: PubMed Mentions: 51 Fields:
    Translation:AnimalsCells
  62. Osteoblast extracellular Ca2+ -sensing receptor regulates bone development, mineralization, and turnover. J Bone Miner Res. 2011 Dec; 26(12):2935-47. Dvorak-Ewell MM, Chen TH, Liang N, Garvey C, Liu B, Tu C, Chang W, Bikle DD, Shoback DM. PMID: 21956637; PMCID: PMC3222747.
    View in: PubMed Mentions: 36 Fields:
    Translation:AnimalsCells
  63. Negative cross-talk between calcium-sensing receptor and β-catenin signaling systems in colonic epithelium. J Biol Chem. 2012 Jan 06; 287(2):1158-67. Rey O, Chang W, Bikle D, Rozengurt N, Young SH, Rozengurt E. PMID: 22094462; PMCID: PMC3256874.
    View in: PubMed Mentions: 32 Fields:
    Translation:HumansAnimalsCells
  64. IGF-1R signaling in chondrocytes modulates growth plate development by interacting with the PTHrP/Ihh pathway. J Bone Miner Res. 2011 Jul; 26(7):1437-46. Wang Y, Cheng Z, Elalieh HZ, Nakamura E, Nguyen MT, Mackem S, Clemens TL, Bikle DD, Chang W. PMID: 21312270; PMCID: PMC3530140.
    View in: PubMed Mentions: 76 Fields:
    Translation:AnimalsCells
  65. Mild Hypothermia Suppresses Calcium-Sensing Receptor (CaSR) Induction Following Forebrain Ischemia While Increasing GABA-B Receptor 1 (GABA-B-R1) Expression. Transl Stroke Res. 2011 Jun 01; 2(2):195-201. Kim JY, Kim N, Yenari MA, Chang W. PMID: 21731589; PMCID: PMC3124781.
    View in: PubMed Mentions: 28 Fields:
  66. The calcium-sensing receptor-dependent regulation of cell-cell adhesion and keratinocyte differentiation requires Rho and filamin A. J Invest Dermatol. 2011 May; 131(5):1119-28. Tu CL, Chang W, Bikle DD. PMID: 21209619; PMCID: PMC3078217.
    View in: PubMed Mentions: 25 Fields:
    Translation:HumansCells
  67. Naturally-occurring mutation in the calcium-sensing receptor reveals the significance of extracellular domain loop III region for class C G-protein-coupled receptor function. J Clin Endocrinol Metab. 2010 Oct; 95(10):E245-52. Dong Q, Cheng Z, Chang W, Blackman BE, Conte FA, Hu J, Shoback D, Miller WL. PMID: 20631026; PMCID: PMC3050095.
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    Translation:HumansCells
  68. Assessing constitutive activity of extracellular calcium-sensing receptors in vitro and in bone. Methods Enzymol. 2010; 484:253-66. Chang W, Dvorak M, Shoback D. PMID: 21036236; PMCID: PMC3528079.
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    Translation:HumansAnimalsCells
  69. The extracellular calcium-sensing receptor (CaSR) is a critical modulator of skeletal development. Sci Signal. 2008 Sep 02; 1(35):ra1. Chang W, Tu C, Chen TH, Bikle D, Shoback D. PMID: 18765830; PMCID: PMC3538864.
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    Translation:HumansAnimalsCells
  70. Inactivation of the calcium sensing receptor inhibits E-cadherin-mediated cell-cell adhesion and calcium-induced differentiation in human epidermal keratinocytes. J Biol Chem. 2008 Feb 08; 283(6):3519-3528. Tu CL, Chang W, Xie Z, Bikle DD. PMID: 18065418.
    View in: PubMed Mentions: 61 Fields:
    Translation:HumansCells
  71. Type B gamma-aminobutyric acid receptors modulate the function of the extracellular Ca2+-sensing receptor and cell differentiation in murine growth plate chondrocytes. Endocrinology. 2007 Oct; 148(10):4984-92. Cheng Z, Tu C, Rodriguez L, Chen TH, Dvorak MM, Margeta M, Gassmann M, Bettler B, Shoback D, Chang W. PMID: 17615148.
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    Translation:AnimalsCells
  72. Complex formation with the Type B gamma-aminobutyric acid receptor affects the expression and signal transduction of the extracellular calcium-sensing receptor. Studies with HEK-293 cells and neurons. J Biol Chem. 2007 Aug 24; 282(34):25030-40. Chang W, Tu C, Cheng Z, Rodriguez L, Chen TH, Gassmann M, Bettler B, Margeta M, Jan LY, Shoback D. PMID: 17591780.
    View in: PubMed Mentions: 40 Fields:
    Translation:HumansAnimalsCells
  73. Constitutive activity of the osteoblast Ca2+-sensing receptor promotes loss of cancellous bone. Endocrinology. 2007 Jul; 148(7):3156-63. Dvorak MM, Chen TH, Orwoll B, Garvey C, Chang W, Bikle DD, Shoback DM. PMID: 17412806.
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    Translation:AnimalsCells
  74. The role of the calcium sensing receptor in regulating intracellular calcium handling in human epidermal keratinocytes. J Invest Dermatol. 2007 May; 127(5):1074-83. Tu CL, Chang W, Bikle DD. PMID: 17124506.
    View in: PubMed Mentions: 37 Fields:
    Translation:HumansCells
  75. WITHDRAWN: Type B gamma-aminobutyric Acid Receptors Modulate the Expression and Function of the Extracellular Ca2+-sensing Receptor in Murine Growth Plate Chondrocytes. Endocrinology. 2006 Sep 05. Cheng Z, Tu C, Rodriguez L, Dvorak MM, Margeta M, Gassmann M, Bettler B, Shoback D, Chang W. PMID: 16728489.
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  76. Insulin-like growth factor-I is essential for embryonic bone development. Endocrinology. 2006 Oct; 147(10):4753-61. Wang Y, Nishida S, Sakata T, Elalieh HZ, Chang W, Halloran BP, Doty SB, Bikle DD. PMID: 16857753; PMCID: PMC10645399.
    View in: PubMed Mentions: 67 Fields:
    Translation:AnimalsCells
  77. Expression and functional assessment of an alternatively spliced extracellular Ca2+-sensing receptor in growth plate chondrocytes. Endocrinology. 2005 Dec; 146(12):5294-303. Rodriguez L, Tu C, Cheng Z, Chen TH, Bikle D, Shoback D, Chang W. PMID: 16166224.
    View in: PubMed Mentions: 24 Fields:
    Translation:HumansAnimalsCells
  78. Extracellular calcium and parathyroid hormone-related peptide signaling modulate the pace of growth plate chondrocyte differentiation. Endocrinology. 2005 Nov; 146(11):4597-608. Rodriguez L, Cheng Z, Chen TH, Tu C, Chang W. PMID: 16099862.
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    Translation:HumansAnimalsCells
  79. Phospholipase cgamma1 is required for activation of store-operated channels in human keratinocytes. J Invest Dermatol. 2005 Jan; 124(1):187-97. Tu CL, Chang W, Bikle DD. PMID: 15654973.
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    Translation:HumansCells
  80. Extracellular Ca2+-sensing in cartilage. J Musculoskelet Neuronal Interact. 2004 Dec; 4(4):410-1. Chang W, Rodriguez L, Chen TH, Tu C, Shoback D. PMID: 15758285.
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    Translation:AnimalsCells
  81. cDNA cloning and functional expression of a Ca2+-sensing receptor with truncated C-terminal tail from the Mozambique tilapia (Oreochromis mossambicus). J Biol Chem. 2004 Dec 17; 279(51):53288-97. Loretz CA, Pollina C, Hyodo S, Takei Y, Chang W, Shoback D. PMID: 15456780.
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    Translation:HumansAnimalsCells
  82. Extracellular Ca2+-sensing receptors--an overview. Cell Calcium. 2004 Mar; 35(3):183-96. Chang W, Shoback D. PMID: 15200142.
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    Translation:HumansAnimalsCells
  83. Nephrotic syndrome and ARF in a diabetic patient. Am J Kidney Dis. 2003 Jun; 41(6):1327-33. Stokes MB, Kwakye J, D'Agati VD. PMID: 12776287.
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    Translation:HumansCells
  84. Hypercortisolemia alters muscle protein anabolism following ingestion of essential amino acids. Am J Physiol Endocrinol Metab. 2003 May; 284(5):E946-53. Paddon-Jones D, Sheffield-Moore M, Creson DL, Sanford AP, Wolf SE, Wolfe RR, Ferrando AA. PMID: 12569085.
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    Translation:HumansCTClinical Trials
  85. Modification of intestinal flora in the treatment of inflammatory bowel disease. Curr Pharm Des. 2003; 9(4):333-46. Kanauchi O, Mitsuyama K, Araki Y, Andoh A. PMID: 12570821.
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    Translation:HumansAnimals
  86. Epidermal expression of the full-length extracellular calcium-sensing receptor is required for normal keratinocyte differentiation. J Cell Physiol. 2002 Jul; 192(1):45-54. Komuves L, Oda Y, Tu CL, Chang WH, Ho-Pao CL, Mauro T, Bikle DD. PMID: 12115735.
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    Translation:AnimalsCells
  87. Extracellular Ca(2+)-sensing receptors modulate matrix production and mineralization in chondrogenic RCJ3.1C5.18 cells. Endocrinology. 2002 Apr; 143(4):1467-74. Chang W, Tu C, Pratt S, Chen TH, Shoback D. PMID: 11897705.
    View in: PubMed Mentions: 23 Fields:
    Translation:AnimalsCells
  88. Amino acids in the cytoplasmic C terminus of the parathyroid Ca2+-sensing receptor mediate efficient cell-surface expression and phospholipase C activation. J Biol Chem. 2001 Nov 23; 276(47):44129-36. Chang W, Pratt S, Chen TH, Bourguignon L, Shoback D. PMID: 11535593.
    View in: PubMed Mentions: 9 Fields:
    Translation:HumansAnimalsCells
  89. Starvation amidst plenty--rickets and hypercalcemia in calcium receptor knockout mice. Endocrinology. 2001 Sep; 142(9):3733-5. Shoback D, Chang W. PMID: 11517147.
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    Translation:Animals
  90. The extracellular calcium-sensing receptor is required for calcium-induced differentiation in human keratinocytes. J Biol Chem. 2001 Nov 02; 276(44):41079-85. Tu CL, Chang W, Bikle DD. PMID: 11500521.
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    Translation:HumansCells
  91. Parathyroid cells express dihydropyridine-sensitive cation currents and L-type calcium channel subunits. Am J Physiol Endocrinol Metab. 2001 Jul; 281(1):E180-9. Chang W, Pratt SA, Chen TH, Tu CL, Mikala G, Schwartz A, Shoback D. PMID: 11404236.
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    Translation:AnimalsCells
  92. Cloning and characterization of human WDR10, a novel gene located at 3q21 encoding a WD-repeat protein that is highly expressed in pituitary and testis. DNA Cell Biol. 2001 Jan; 20(1):41-52. Gross C, De Baere E, Lo A, Chang W, Messiaen L. PMID: 11242542.
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    Translation:HumansAnimalsCells
  93. Amino acids in the second and third intracellular loops of the parathyroid Ca2+-sensing receptor mediate efficient coupling to phospholipase C. J Biol Chem. 2000 Jun 30; 275(26):19955-63. Chang W, Chen TH, Pratt S, Shoback D. PMID: 10764812.
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    Translation:HumansAnimalsCells
  94. The calcium sensing receptor and its alternatively spliced form in murine epidermal differentiation. J Biol Chem. 2000 Jan 14; 275(2):1183-90. Oda Y, Tu CL, Chang W, Crumrine D, Kömüves L, Mauro T, Elias PM, Bikle DD. PMID: 10625662.
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    Translation:HumansAnimalsCells
  95. Protein kinase C activation blocks calcium receptor signaling in Xenopus laevis oocytes. Mol Cell Endocrinol. 1999 Dec 20; 158(1-2):13-23. Chang W, Pratt S, Chen TH, Shoback D. PMID: 10630401.
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    Translation:AnimalsCells
  96. Expression and signal transduction of calcium-sensing receptors in cartilage and bone. Endocrinology. 1999 Dec; 140(12):5883-93. Chang W, Tu C, Chen TH, Komuves L, Oda Y, Pratt SA, Miller S, Shoback D. PMID: 10579354.
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    Translation:HumansAnimalsCells
  97. Calcium sensing in cultured chondrogenic RCJ3.1C5.18 cells. Endocrinology. 1999 Apr; 140(4):1911-9. Chang W, Tu C, Bajra R, Komuves L, Miller S, Strewler G, Shoback D. PMID: 10098531.
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    Translation:AnimalsCells
  98. Regulation of extracellular calcium-activated cation currents by cAMP in parathyroid cells. Am J Physiol. 1998 08; 275(2):E213-21. Chang W, Chen TH, Pratt S, Shoback D. PMID: 9688621.
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    Translation:AnimalsCells
  99. Coupling of calcium receptors to inositol phosphate and cyclic AMP generation in mammalian cells and Xenopus laevis oocytes and immunodetection of receptor protein by region-specific antipeptide antisera. J Bone Miner Res. 1998 Apr; 13(4):570-80. Chang W, Pratt S, Chen TH, Nemeth E, Huang Z, Shoback D. PMID: 9556057.
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  100. Parathyroid Ca(2+)-conducting currents are modulated by muscarinic receptor agonists and antagonists. Am J Physiol. 1997 11; 273(5):E880-90. Chang W, Chen TH, Pratt SA, Yen B, Fu M, Shoback D. PMID: 9374672.
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    Translation:HumansAnimalsCells
  101. Regulation of Ca(2+)-conducting currents in parathyroid cells by extracellular Ca(2+) and channel blockers. Am J Physiol. 1995 Nov; 269(5 Pt 1):E864-77. Chang W, Chen TH, Gardner P, Shoback D. PMID: 7491938.
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    Translation:AnimalsCells
  102. DPC blockade of transepithelial chloride absorption and single anion channels in teleost urinary bladder. Am J Physiol. 1993 Jul; 265(1 Pt 2):R66-75. Chang W, Loretz CA. PMID: 7688192.
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    Translation:AnimalsCells
  103. Identification of a stretch-activated monovalent cation channel from teleost urinary bladder cells. J Exp Zool. 1991 Sep; 259(3):304-15. Chang WH, Loretz CA. PMID: 1717636.
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    Translation:Animals
  104. Amines and the rat exocrine pancreas: (1). Effects of receptor blockers on turnover of L-dopa. Jpn J Pharmacol. 1979 Dec; 29(6):899-911. Mori J, Satoh Y, Hashimoto M, Honda F. PMID: 44324.
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    Translation:Animals
  105. Some physicochemical properties of hemoglobin-manitoba (alpha2 102Ser replaced by Arg (G9) beta2). Biochim Biophys Acta. 1975 Dec 15; 412(2):283-7. Wrightstone RN, Smith LL, Wilson JB, Vella F, Huisman TH. PMID: 87.
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    Translation:Humans
  106. Beef liver L-Glutamate dehydrogenase mechanism: presteady state study of the catalytic reduction of 2.oxoglutarate by NADPH. Biochem Biophys Res Commun. 1975 Dec 15; 67(4):1527-36. Jallon JM, Risler Y, Iwatsubo M. PMID: 1038.
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  107. Pharmacological properties of new neuroleptic compounds. Arzneimittelforschung. 1975 Sep; 25(9):1436-42. Coscia L, Causa P, Giuliani E, Nunziata A. PMID: 25.
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  108. Digitoxin metabolism by rat liver microsomes. Biochem Pharmacol. 1975 Sep 01; 24(17):1639-41. Schmoldt A, Benthe HF, Haberland G. PMID: 10.
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