Reciprocal control of T helper cell and dendritic cell differentiation - PubMed (original) (raw)
Reciprocal control of T helper cell and dendritic cell differentiation
M C Rissoan et al. Science. 1999.
Abstract
It is not known whether subsets of dendritic cells provide different cytokine microenvironments that determine the differentiation of either type-1 T helper (TH1) or TH2 cells. Human monocyte (pDC1)-derived dendritic cells (DC1) were found to induce TH1 differentiation, whereas dendritic cells (DC2) derived from CD4+CD3-CD11c- plasmacytoid cells (pDC2) induced TH2 differentiation by use of a mechanism unaffected by interleukin-4 (IL-4) or IL-12. The TH2 cytokine IL-4 enhanced DC1 maturation and killed pDC2, an effect potentiated by IL-10 but blocked by CD40 ligand and interferon-gamma. Thus, a negative feedback loop from the mature T helper cells may selectively inhibit prolonged TH1 or TH2 responses by regulating survival of the appropriate dendritic cell subset.
Comment in
- T cells and dendritic cells get intimate.
Bottomly K. Bottomly K. Science. 1999 Feb 19;283(5405):1124-5. doi: 10.1126/science.283.5405.1124. Science. 1999. PMID: 10075571 No abstract available.
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