Response of hippocampal synapses to natural stimulation patterns - PubMed (original) (raw)
Response of hippocampal synapses to natural stimulation patterns
L E Dobrunz et al. Neuron. 1999 Jan.
Free article
Abstract
We have studied the synaptic responses in hippocampal slices to stimulus patterns derived from in vivo recordings of place cell firing in a behaving rodent. We find that synaptic strength is strongly modulated during the presentation of these natural stimulus trains, varying 2-fold or more because of short-term plasticity. This modulation of synaptic strength is precise and deterministic, because the pattern of synaptic response amplitudes is nearly identical from one presentation of the train to the next. The mechanism of synaptic modulation is primarily a change in release probability rather than a change in the size of the elementary postsynaptic response. In addition, natural stimulus trains are effective in inducing long-term potentiation (LTP). We conclude that short-term synaptic plasticity--facilitation, augmentation, and depression--plays a prominent role in normal synaptic function.
Similar articles
- Natural spike trains trigger short- and long-lasting dynamics at hippocampal mossy fiber synapses in rodents.
Gundlfinger A, Breustedt J, Sullivan D, Schmitz D. Gundlfinger A, et al. PLoS One. 2010 Apr 1;5(4):e9961. doi: 10.1371/journal.pone.0009961. PLoS One. 2010. PMID: 20376354 Free PMC article. - Differential maintenance and frequency-dependent tuning of LTP at hippocampal synapses of specific strains of inbred mice.
Nguyen PV, Duffy SN, Young JZ. Nguyen PV, et al. J Neurophysiol. 2000 Nov;84(5):2484-93. doi: 10.1152/jn.2000.84.5.2484. J Neurophysiol. 2000. PMID: 11067991 - Differences in multiple forms of short-term plasticity between excitatory and inhibitory hippocampal neurons in culture.
Kaplan MP, Wilcox KS, Dichter MA. Kaplan MP, et al. Synapse. 2003 Oct;50(1):41-52. doi: 10.1002/syn.10244. Synapse. 2003. PMID: 12872293 - Molecular consequences of diffusible signaling: locally distributed synaptic enhancement in hippocampal neurons.
Schuman EM. Schuman EM. Semin Cell Biol. 1994 Aug;5(4):251-61. doi: 10.1006/scel.1994.1031. Semin Cell Biol. 1994. PMID: 7994009 Review. - Modulation of inhibitory synapses in the mammalian brain.
Marty A, Llano I. Marty A, et al. Curr Opin Neurobiol. 1995 Jun;5(3):335-41. doi: 10.1016/0959-4388(95)80046-8. Curr Opin Neurobiol. 1995. PMID: 7580156 Review.
Cited by
- Spike timing and visual processing in the retinogeniculocortical pathway.
Usrey WM. Usrey WM. Philos Trans R Soc Lond B Biol Sci. 2002 Dec 29;357(1428):1729-37. doi: 10.1098/rstb.2002.1157. Philos Trans R Soc Lond B Biol Sci. 2002. PMID: 12626007 Free PMC article. Review. - Differential modulation of short-term synaptic dynamics by long-term potentiation at mouse hippocampal mossy fibre synapses.
Gundlfinger A, Leibold C, Gebert K, Moisel M, Schmitz D, Kempter R. Gundlfinger A, et al. J Physiol. 2007 Dec 15;585(Pt 3):853-65. doi: 10.1113/jphysiol.2007.143925. Epub 2007 Oct 25. J Physiol. 2007. PMID: 17962326 Free PMC article. - Hebbian modification of a hippocampal population pattern in the rat.
King C, Henze DA, Leinekugel X, Buzsáki G. King C, et al. J Physiol. 1999 Nov 15;521 Pt 1(Pt 1):159-67. doi: 10.1111/j.1469-7793.1999.00159.x. J Physiol. 1999. PMID: 10562342 Free PMC article. - Precise firing events are conserved across neurons.
Reinagel P, Reid RC. Reinagel P, et al. J Neurosci. 2002 Aug 15;22(16):6837-41. doi: 10.1523/JNEUROSCI.22-16-06837.2002. J Neurosci. 2002. PMID: 12177180 Free PMC article. - An unusual C(2)-domain in the active-zone protein piccolo: implications for Ca(2+) regulation of neurotransmitter release.
Gerber SH, Garcia J, Rizo J, Südhof TC. Gerber SH, et al. EMBO J. 2001 Apr 2;20(7):1605-19. doi: 10.1093/emboj/20.7.1605. EMBO J. 2001. PMID: 11285225 Free PMC article.