Presenilins interact with armadillo proteins including neural-specific plakophilin-related protein and beta-catenin - PubMed (original) (raw)

. 1999 Mar;72(3):999-1008.

doi: 10.1046/j.1471-4159.1999.0720999.x.

G Yu, M Nishimura, D M Zhang, L Levesque, H Yu, D Xu, Y Liang, E Rogaeva, M Ikeda, M Duthie, N Murgolo, L Wang, P VanderVere, M L Bayne, C D Strader, J M Rommens, P E Fraser, P St George-Hyslop

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G Levesque et al. J Neurochem. 1999 Mar.

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Abstract

Missense substitutions in the presenilin 1 (PS1) and presenilin 2 (PS2) proteins are associated with early-onset familial Alzheimer's disease. We have used yeast-two-hybrid and coimmunoprecipitation methods to show that the large cytoplasmic loop domains of PS1 and PS2 interact specifically with three members of the armadillo protein family, including beta-catenin, p0071, and a novel neuronal-specific armadillo protein--neural plakophilin-related armadillo protein (NPRAP). The PS1:NPRAP interaction occurs between the arm repeats of NPRAP and residues 372-399 at the C-terminal end of the large cytoplasmic loop of PS1. The latter residues contain a single arm-like domain and are highly conserved in the presenilins, suggesting that they form a functional armadillo protein binding site for the presenilins.

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