All oxygens in nucleic acids react with carcinogenic ethylating agents - PubMed (original) (raw)

. 1976 Nov 25;264(5584):333-9.

doi: 10.1038/264333a0.

All oxygens in nucleic acids react with carcinogenic ethylating agents

B Singer. Nature. 1976.

Abstract

Over 80% of ethylnitrosourea and ethylnitrosoguanidine modification of nucleic acids is on oxygens. The reactivity of oxygens (other than ribose and phosphate) in single-stranded RNA is: O2 of C greater than O2 of U greater than O6 of G greater than O4 of U. In double-stranded DNA the order is: O2 of T equals O6 of G greater than O4 of T greater than O2 of C. Oxygen reactivity of single-stranded DNA resembles RNA. The glycosidic bond of O2-alkylpyrimidines is labilised.

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