Evidence for a rare prostate cancer-susceptibility locus at chromosome 1p36 - PubMed (original) (raw)
J L Stanford, R A McIndoe, G P Jarvik, S Kolb, E L Goode, L Chakrabarti, E F Schuster, V A Buckley, E L Miller, S Brandzel, S Li, L Hood, E A Ostrander
Affiliations
- PMID: 10053012
- PMCID: PMC1377795
- DOI: 10.1086/302287
Evidence for a rare prostate cancer-susceptibility locus at chromosome 1p36
M Gibbs et al. Am J Hum Genet. 1999 Mar.
Abstract
Combining data from a genomic screen in 70 families with a high risk for prostate cancer (PC) with data from candidate-region mapping in these families and an additional 71 families, we have localized a potential hereditary PC-susceptibility locus to chromosome 1p36. Because an excess of cases of primary brain cancer (BC) have been observed in some studies of families with a high risk for PC, and because loss of heterozygosity at 1p36 is frequently observed in BC, we further evaluated 12 families with both a history of PC and a blood relative with primary BC. The overall LOD score in these 12 families was 3.22 at a recombination fraction (theta) of .06, with marker D1S507. On the basis of an a priori hypothesis, this group was stratified by age at diagnosis of PC. In the younger age group (mean age at diagnosis <66 years), a maximum two-point LOD score of 3.65 at straight theta = .0 was observed, with D1S407. This linkage was rejected in both early- and late-onset families without a history of BC (LOD scores -7.12 and -6.03, respectively, at straight theta = .0). After exclusion of 3 of the 12 families that had better evidence of linkage to previously described PC-susceptibility loci, linkage to the 1p36 region was suggested by a two-point LOD score of 4.74 at straight theta = .0, with marker D1S407. We conclude that a significant proportion of these families with both a high risk for PC and a family member with BC show linkage to the 1p36 region.
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