The oncogenic activation of beta-catenin - PubMed (original) (raw)
Review
The oncogenic activation of beta-catenin
P Polakis. Curr Opin Genet Dev. 1999 Feb.
Abstract
The activation of beta-catenin to an oncogenic state can result from the inactivation of the tumor suppressor adenomatous polyposis coli (APC), by direct mutation in the beta-catenin gene, or by the activation of wnt receptors. Once activated, beta-catenin most likely promotes tumor progression through its persistent interaction with one or more of its numerous downstream targets.
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