Bi-cycling the furin pathway: from TGN localization to pathogen activation and embryogenesis - PubMed (original) (raw)
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Bi-cycling the furin pathway: from TGN localization to pathogen activation and embryogenesis
S S Molloy et al. Trends Cell Biol. 1999 Jan.
Abstract
Furin is a secretory pathway endoprotease that catalyses the maturation of a strikingly diverse group of proprotein substrates, ranging from growth factors and receptors to pathogen proteins, in multiple compartments within the trans-Golgi network (TGN)/endosomal system. This review focuses on recent developments in the biochemistry and cell biology of the endoprotease, including the mechanism of TGN localization, phosphorylation-dependent regulation of protein traffic, and novel insights into early embryogenesis, extracellular matrix formation and pathogen virulence.
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