Somatic hypermutation and the three R's: repair, replication and recombination - PubMed (original) (raw)
Review
Somatic hypermutation and the three R's: repair, replication and recombination
R S Harris et al. Mutat Res. 1999 Mar.
Free article
Abstract
Somatic hypermutation introduces single base changes into the rearranged variable (V) regions of antigen activated B cells at a rate of approximately 1 mutation per kilobase per generation. This is nearly a million-fold higher than the typical mutation rate in a mammalian somatic cell. Rampant mutation at this level could have a devastating effect, but somatic hypermutation is accurately targeted and tightly regulated. Here, we provide an overview of immunoglobulin gene somatic hypermutation; discuss mechanisms of mutation in model organisms that may be relevant to the hypermutation mechanism; and review recent advances toward understanding the possible role(s) of DNA repair, replication, and recombination in this fascinating process.
Copyright 1999 Elsevier Science B.V.
Similar articles
- Recombination-based mechanisms for somatic hypermutation.
Kong Q, Harris RS, Maizels N. Kong Q, et al. Immunol Rev. 1998 Apr;162:67-76. doi: 10.1111/j.1600-065x.1998.tb01430.x. Immunol Rev. 1998. PMID: 9602353 Review. - Mutagenesis and the three R's in yeast.
Abdulovic A, Kim N, Jinks-Robertson S. Abdulovic A, et al. DNA Repair (Amst). 2006 Apr 8;5(4):409-21. doi: 10.1016/j.dnarep.2005.11.006. Epub 2006 Jan 10. DNA Repair (Amst). 2006. PMID: 16412705 Review. - Hypermutation of immunoglobulin genes in memory B cells of DNA repair-deficient mice.
Jacobs H, Fukita Y, van der Horst GT, de Boer J, Weeda G, Essers J, de Wind N, Engelward BP, Samson L, Verbeek S, de Murcia JM, de Murcia G, te Riele H, Rajewsky K. Jacobs H, et al. J Exp Med. 1998 Jun 1;187(11):1735-43. doi: 10.1084/jem.187.11.1735. J Exp Med. 1998. PMID: 9607915 Free PMC article. - DNA damage and repair during lymphoid development: antigen receptor diversity, genomic integrity and lymphomagenesis.
Puebla-Osorio N, Zhu C. Puebla-Osorio N, et al. Immunol Res. 2008;41(2):103-22. doi: 10.1007/s12026-008-8015-3. Immunol Res. 2008. PMID: 18214391 Review. - The Complex Interplay between DNA Injury and Repair in Enzymatically Induced Mutagenesis and DNA Damage in B Lymphocytes.
Bahjat M, Guikema JEJ. Bahjat M, et al. Int J Mol Sci. 2017 Aug 30;18(9):1876. doi: 10.3390/ijms18091876. Int J Mol Sci. 2017. PMID: 28867784 Free PMC article. Review.
Cited by
- Programmed DNA Damage and Physiological DSBs: Mapping, Biological Significance and Perturbations in Disease States.
Oster S, Aqeilan RI. Oster S, et al. Cells. 2020 Aug 10;9(8):1870. doi: 10.3390/cells9081870. Cells. 2020. PMID: 32785139 Free PMC article. Review. - The KT Jeang Prize 2019: Reuben S. Harris : Romancing the Mutator.
Retrovirology Editorial. Retrovirology Editorial. Retrovirology. 2019 Aug 29;16(1):24. doi: 10.1186/s12977-019-0486-x. Retrovirology. 2019. PMID: 31462326 Free PMC article. No abstract available. - Naïve Human Antibody Libraries for Infectious Diseases.
Chan SK, Rahumatullah A, Lai JY, Lim TS. Chan SK, et al. Adv Exp Med Biol. 2017;1053:35-59. doi: 10.1007/978-3-319-72077-7_3. Adv Exp Med Biol. 2017. PMID: 29549634 Free PMC article. Review. - Trade-offs in antibody repertoires to complex antigens.
Childs LM, Baskerville EB, Cobey S. Childs LM, et al. Philos Trans R Soc Lond B Biol Sci. 2015 Sep 5;370(1676):20140245. doi: 10.1098/rstb.2014.0245. Philos Trans R Soc Lond B Biol Sci. 2015. PMID: 26194759 Free PMC article. - Exome-wide somatic microsatellite variation is altered in cells with DNA repair deficiencies.
Vaksman Z, Fonville NC, Tae H, Garner HR. Vaksman Z, et al. PLoS One. 2014 Nov 17;9(11):e110263. doi: 10.1371/journal.pone.0110263. eCollection 2014. PLoS One. 2014. PMID: 25402475 Free PMC article.