Dynamic control of CaMKII translocation and localization in hippocampal neurons by NMDA receptor stimulation - PubMed (original) (raw)

Dynamic control of CaMKII translocation and localization in hippocampal neurons by NMDA receptor stimulation

K Shen et al. Science. 1999.

Abstract

Calcium-calmodulin-dependent protein kinase II (CaMKII) is thought to increase synaptic strength by phosphorylating postsynaptic density (PSD) ion channels and signaling proteins. It is shown that N-methyl-D-aspartate (NMDA) receptor stimulation reversibly translocates green fluorescent protein-tagged CaMKII from an F-actin-bound to a PSD-bound state. The translocation time was controlled by the ratio of expressed beta-CaMKII to alpha-CaMKII isoforms. Although F-actin dissociation into the cytosol required autophosphorylation of or calcium-calmodulin binding to beta-CaMKII, PSD translocation required binding of calcium-calmodulin to either the alpha- or beta-CaMKII subunits. Autophosphorylation of CaMKII indirectly prolongs its PSD localization by increasing the calmodulin-binding affinity.

PubMed Disclaimer

Similar articles

• CaMKII-dependent phosphorylation of NR2A and NR2B is decreased in animals characterized by hippocampal damage and impaired LTP.
  Caputi A, Gardoni F, Cimino M, Pastorino L, Cattabeni F, Di Luca M. Caputi A, et al. Eur J Neurosci. 1999 Jan;11(1):141-8. doi: 10.1046/j.1460-9568.1999.00414.x. Eur J Neurosci. 1999. PMID: 9987018
• Transition from reversible to persistent binding of CaMKII to postsynaptic sites and NR2B.
  Bayer KU, LeBel E, McDonald GL, O'Leary H, Schulman H, De Koninck P. Bayer KU, et al. J Neurosci. 2006 Jan 25;26(4):1164-74. doi: 10.1523/JNEUROSCI.3116-05.2006. J Neurosci. 2006. PMID: 16436603 Free PMC article.
• Calcium/calmodulin-dependent protein kinase II is associated with NR2A/B subunits of NMDA receptor in postsynaptic densities.
  Gardoni F, Caputi A, Cimino M, Pastorino L, Cattabeni F, Di Luca M. Gardoni F, et al. J Neurochem. 1998 Oct;71(4):1733-41. doi: 10.1046/j.1471-4159.1998.71041733.x. J Neurochem. 1998. PMID: 9751209
• Targeting of calcium/calmodulin-dependent protein kinase II.
  Colbran RJ. Colbran RJ. Biochem J. 2004 Feb 15;378(Pt 1):1-16. doi: 10.1042/BJ20031547. Biochem J. 2004. PMID: 14653781 Free PMC article. Review.
• Activity-driven postsynaptic translocation of CaMKII.
  Merrill MA, Chen Y, Strack S, Hell JW. Merrill MA, et al. Trends Pharmacol Sci. 2005 Dec;26(12):645-53. doi: 10.1016/j.tips.2005.10.003. Epub 2005 Oct 25. Trends Pharmacol Sci. 2005. PMID: 16253351 Review.

Cited by

• Vascular CaMKII: heart and brain in your arteries.
  Toussaint F, Charbel C, Allen BG, Ledoux J. Toussaint F, et al. Am J Physiol Cell Physiol. 2016 Sep 1;311(3):C462-78. doi: 10.1152/ajpcell.00341.2015. Epub 2016 Jun 15. Am J Physiol Cell Physiol. 2016. PMID: 27306369 Free PMC article. Review.
• Dentate gyrus-specific manipulation of beta-Ca2+/calmodulin-dependent kinase II disrupts memory consolidation.
  Cho MH, Cao X, Wang D, Tsien JZ. Cho MH, et al. Proc Natl Acad Sci U S A. 2007 Oct 9;104(41):16317-22. doi: 10.1073/pnas.0703344104. Epub 2007 Oct 3. Proc Natl Acad Sci U S A. 2007. PMID: 17913888 Free PMC article.
• PICK1 targets activated protein kinase Calpha to AMPA receptor clusters in spines of hippocampal neurons and reduces surface levels of the AMPA-type glutamate receptor subunit 2.
  Perez JL, Khatri L, Chang C, Srivastava S, Osten P, Ziff EB. Perez JL, et al. J Neurosci. 2001 Aug 1;21(15):5417-28. doi: 10.1523/JNEUROSCI.21-15-05417.2001. J Neurosci. 2001. PMID: 11466413 Free PMC article.
• A network of networks: cytoskeletal control of compartmentalized function within dendritic spines.
  Frost NA, Kerr JM, Lu HE, Blanpied TA. Frost NA, et al. Curr Opin Neurobiol. 2010 Oct;20(5):578-87. doi: 10.1016/j.conb.2010.06.009. Curr Opin Neurobiol. 2010. PMID: 20667710 Free PMC article. Review.
• Variability of distribution of Ca(2+)/calmodulin-dependent kinase II at mixed synapses on the mauthner cell: colocalization and association with connexin 35.
  Flores CE, Cachope R, Nannapaneni S, Ene S, Nairn AC, Pereda AE. Flores CE, et al. J Neurosci. 2010 Jul 14;30(28):9488-99. doi: 10.1523/JNEUROSCI.4466-09.2010. J Neurosci. 2010. PMID: 20631177 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Atypon
  • Ovid Technologies, Inc.

• Other Literature Sources

  • The Lens - Patent Citations Database

• Molecular Biology Databases

  • Gene Ontology

• Research Materials

  • Addgene Non-profit plasmid repository