Neurite growth inhibitors restrict plasticity and functional recovery following corticospinal tract lesions - PubMed (original) (raw)

Neurite growth inhibitors restrict plasticity and functional recovery following corticospinal tract lesions

M Thallmair et al. Nat Neurosci. 1998 Jun.

Erratum in

• Nat Neurosci 1998 Aug;1(4):329

Abstract

Anatomical plasticity and functional recovery after lesions of the rodent corticospinal tract (CST) decrease postnatally in parallel with myelin formation. Myelin-associated neurite growth inhibitory proteins prevent regenerative fiber growth, but whether they also prevent reactive sprouting of unlesioned fibers is less clear. Here we show that after unilateral CST lesion in the adult rat brainstem, both intact and lesioned tracts show topographically appropriate sprouting after treatment with a monoclonal antibody that neutralizes these inhibitory proteins. Antibody-treated animals showed full recovery in motor and sensory tests, whereas untreated lesioned rats exhibited persistent severe deficits. Neutralization of myelin-associated neurite growth inhibitors thus restores in adults the structural plasticity and functional recovery normally found only at perinatal ages.

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Comment in

• New compensations for spinal injury.
  [No authors listed] [No authors listed] Nat Neurosci. 1998 Jun;1(2):85. doi: 10.1038/330. Nat Neurosci. 1998. PMID: 10195115 No abstract available.
• Containing plasticity: neurite inhibitory factors of myelin.
  Blight AR. Blight AR. Nat Neurosci. 1998 Jun;1(2):87-8. doi: 10.1038/331. Nat Neurosci. 1998. PMID: 10195116 No abstract available.

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