Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus - PubMed (original) (raw)
Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus
H van Praag et al. Nat Neurosci. 1999 Mar.
Abstract
Exposure to an enriched environment increases neurogenesis in the dentate gyrus of adult rodents. Environmental enrichment, however, typically consists of many components, such as expanded learning opportunities, increased social interaction, more physical activity and larger housing. We attempted to separate components by assigning adult mice to various conditions: water-maze learning (learner), swim-time-yoked control (swimmer), voluntary wheel running (runner), and enriched (enriched) and standard housing (control) groups. Neither maze training nor yoked swimming had any effect on bromodeoxyuridine (BrdU)-positive cell number. However, running doubled the number of surviving newborn cells, in amounts similar to enrichment conditions. Our findings demonstrate that voluntary exercise is sufficient for enhanced neurogenesis in the adult mouse dentate gyrus.
Comment in
- New neurons in old brains: learning to survive?
Greenough WT, Cohen NJ, Juraska JM. Greenough WT, et al. Nat Neurosci. 1999 Mar;2(3):203-5. doi: 10.1038/6300. Nat Neurosci. 1999. PMID: 10195209 No abstract available. - Outsmarting (and outrunning) nature's harsh decree.
Drew MR, Denny CA. Drew MR, et al. Nat Neurosci. 2018 Sep;21(9):1141-1142. doi: 10.1038/s41593-018-0214-1. Nat Neurosci. 2018. PMID: 30127426 No abstract available.
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