Emerging roles of caspase-3 in apoptosis - PubMed (original) (raw)
Review
Emerging roles of caspase-3 in apoptosis
A G Porter et al. Cell Death Differ. 1999 Feb.
Abstract
Caspases are crucial mediators of programmed cell death (apoptosis). Among them, caspase-3 is a frequently activated death protease, catalyzing the specific cleavage of many key cellular proteins. However, the specific requirements of this (or any other) caspase in apoptosis have remained largely unknown until now. Pathways to caspase-3 activation have been identified that are either dependent on or independent of mitochondrial cytochrome c release and caspase-9 function. Caspase-3 is essential for normal brain development and is important or essential in other apoptotic scenarios in a remarkable tissue-, cell type- or death stimulus-specific manner. Caspase-3 is also required for some typical hallmarks of apoptosis, and is indispensable for apoptotic chromatin condensation and DNA fragmentation in all cell types examined. Thus, caspase-3 is essential for certain processes associated with the dismantling of the cell and the formation of apoptotic bodies, but it may also function before or at the stage when commitment to loss of cell viability is made.
Similar articles
- Caspase-3 is required for apoptosis-associated DNA fragmentation but not for cell death in neurons deprived of potassium.
D'Mello SR, Kuan CY, Flavell RA, Rakic P. D'Mello SR, et al. J Neurosci Res. 2000 Jan 1;59(1):24-31. J Neurosci Res. 2000. PMID: 10658182 - Apoptosis: mechanisms and relevance in cancer.
Vermeulen K, Van Bockstaele DR, Berneman ZN. Vermeulen K, et al. Ann Hematol. 2005 Oct;84(10):627-39. doi: 10.1007/s00277-005-1065-x. Epub 2005 Jul 22. Ann Hematol. 2005. PMID: 16041532 Review. - Caspase-8 in apoptosis: the beginning of "the end"?
Kruidering M, Evan GI. Kruidering M, et al. IUBMB Life. 2000 Aug;50(2):85-90. doi: 10.1080/713803693. IUBMB Life. 2000. PMID: 11185963 Review. - Manganese Superoxide Dismutase Affects Cytochrome c Release and Caspase-9 Activation After Transient Focal Cerebral Ischemia in Mice.
Noshita N, Sugawara T, Fujimura M, Morita-Fujimura Y, Chan PH. Noshita N, et al. J Cereb Blood Flow Metab. 2001 May;21(5):557-67. doi: 10.1097/00004647-200105000-00010. J Cereb Blood Flow Metab. 2001. PMID: 11333366
Cited by
- Mitochondrial rewiring with small-molecule drug-free nanoassemblies unleashes anticancer immunity.
Ren L, Wan J, Li X, Yao J, Ma Y, Meng F, Zheng S, Han W, Wang H. Ren L, et al. Nat Commun. 2024 Sep 3;15(1):7664. doi: 10.1038/s41467-024-51945-y. Nat Commun. 2024. PMID: 39227567 Free PMC article. - Heat-mediated reduction of apoptosis in UVB-damaged keratinocytes in vitro and in human skin ex vivo.
Calapre L, Gray ES, Kurdykowski S, David A, Hart P, Descargues P, Ziman M. Calapre L, et al. BMC Dermatol. 2016 May 26;16(1):6. doi: 10.1186/s12895-016-0043-4. BMC Dermatol. 2016. PMID: 27230291 Free PMC article. - Knock down of heat shock protein 27 (HspB1) induces degradation of several putative client proteins.
Gibert B, Eckel B, Fasquelle L, Moulin M, Bouhallier F, Gonin V, Mellier G, Simon S, Kretz-Remy C, Arrigo AP, Diaz-Latoud C. Gibert B, et al. PLoS One. 2012;7(1):e29719. doi: 10.1371/journal.pone.0029719. Epub 2012 Jan 4. PLoS One. 2012. PMID: 22238643 Free PMC article. - Cell-free hemoglobin-mediated human lung microvascular endothelial barrier dysfunction is not mediated by cell death.
Tomasek T, Ware LB, Bastarache JA, Meegan JE. Tomasek T, et al. Biochem Biophys Res Commun. 2021 Jun 4;556:199-206. doi: 10.1016/j.bbrc.2021.03.161. Epub 2021 Apr 10. Biochem Biophys Res Commun. 2021. PMID: 33848934 Free PMC article. - Cytotoxic CD8+ T cells may be drivers of tissue destruction in Sjögren's syndrome.
Kaneko N, Chen H, Perugino CA, Maehara T, Munemura R, Yokomizo S, Sameshima J, Diefenbach TJ, Premo KR, Chinju A, Miyahara Y, Sakamoto M, Moriyama M, Stone JH, Nakamura S, Pillai S. Kaneko N, et al. Sci Rep. 2022 Sep 14;12(1):15427. doi: 10.1038/s41598-022-19397-w. Sci Rep. 2022. PMID: 36104369 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials