Folate metabolism and requirements - PubMed (original) (raw)

Review

. 1999 Apr;129(4):779-82.

doi: 10.1093/jn/129.4.779.

Affiliations

• PMID: 10203550
• DOI: 10.1093/jn/129.4.779

Review

Folate metabolism and requirements

L B Bailey et al. J Nutr. 1999 Apr.

Abstract

Folate functions in multiple coenzyme forms in acceptance, redox processing and transfer of one-carbon units, including nucleotides and certain amino acids. Folate-requiring metabolic processes are influenced by folate intake, intake of other essential nutrients, including vitamins B-12 and B-6, and at least one common genetic polymorphism. Estimates of folate requirements have been based on intakes associated with maintenance of normal plasma and erythrocyte folate concentrations and functional tests that reflect abnormalities in folate-dependent reactions. Dietary Reference Intakes for folate that have been developed recently are based primarily on metabolic studies in which erythrocyte folate concentration was considered the major indicator of adequacy. For adults >/=19 y, the Recommended Dietary Allowance (RDA) is 400 microg/d of dietary folate equivalents (DFE); for lactating and pregnant women, the RDAs include an additional 100 and 200 microg of DFE/d, respectively.

PubMed Disclaimer

Similar articles

• New standard for dietary folate intake in pregnant women.
  Bailey LB. Bailey LB. Am J Clin Nutr. 2000 May;71(5 Suppl):1304S-7S. doi: 10.1093/ajcn/71.5.1304s. Am J Clin Nutr. 2000. PMID: 10799406 Review.
• Methylenetetrahydrofolate reductase 677C-->T variant modulates folate status response to controlled folate intakes in young women.
  Guinotte CL, Burns MG, Axume JA, Hata H, Urrutia TF, Alamilla A, McCabe D, Singgih A, Cogger EA, Caudill MA. Guinotte CL, et al. J Nutr. 2003 May;133(5):1272-80. doi: 10.1093/jn/133.5.1272. J Nutr. 2003. PMID: 12730409
• Folate status response to controlled folate intake in pregnant women.
  Caudill MA, Cruz AC, Gregory JF 3rd, Hutson AD, Bailey LB. Caudill MA, et al. J Nutr. 1997 Dec;127(12):2363-70. doi: 10.1093/jn/127.12.2363. J Nutr. 1997. PMID: 9405587 Clinical Trial.
• Dietary reference intakes for folate: the debut of dietary folate equivalents.
  Bailey LB. Bailey LB. Nutr Rev. 1998 Oct;56(10):294-9. doi: 10.1111/j.1753-4887.1998.tb01662.x. Nutr Rev. 1998. PMID: 9810807 Review.
• Folate requirements for health in different population groups.
  McNulty H. McNulty H. Br J Biomed Sci. 1995 Jun;52(2):110-9. Br J Biomed Sci. 1995. PMID: 8520248 Review.

Cited by

• Supplementation with Folic Acid or 5-Methyltetrahydrofolate and Prevention of Neural Tube Defects: An Evidence-Based Narrative Review.
  Samaniego-Vaesken ML, Morais-Moreno C, Carretero-Krug A, Puga AM, Montero-Bravo AM, Partearroyo T, Gregorio VM. Samaniego-Vaesken ML, et al. Nutrients. 2024 Sep 18;16(18):3154. doi: 10.3390/nu16183154. Nutrients. 2024. PMID: 39339754 Free PMC article. Review.
• Treatment with Epigallocatechin Gallate, Folic Acid, Vitamin B12, and Hyaluronic Acid Decreases HPV Positivity in Women Attending Regional Screening in Puglia.
  Tinelli A, Gustapane S, Licchelli M, Coluccia AC, Panese G, Proietti S, Gambioli R. Tinelli A, et al. Microorganisms. 2024 Sep 14;12(9):1897. doi: 10.3390/microorganisms12091897. Microorganisms. 2024. PMID: 39338571 Free PMC article.
• [Maternal MTR gene polymorphisms and their interactions with periconceptional folic acid supplementation in relation to offspring ventricular septal defects].
  Ruan XR, Sun MT, Wei JH, Luo MJ, Liu HJ, Tang JP, Li LX, Qin JB. Ruan XR, et al. Zhongguo Dang Dai Er Ke Za Zhi. 2024 Sept 15;26(9):899-906. doi: 10.7499/j.issn.1008-8830.2403067. Zhongguo Dang Dai Er Ke Za Zhi. 2024. PMID: 39267503 Free PMC article. Chinese.
• Micronutrients Importance in Cancer Prevention-Vitamins.
  Saeed RF, Naz S, Awan UA, Gul S, Subhan F, Saeed S. Saeed RF, et al. Cancer Treat Res. 2024;191:119-144. doi: 10.1007/978-3-031-55622-7_5. Cancer Treat Res. 2024. PMID: 39133406 Review.
• Geographical distribution of MTHFR C677T gene polymorphisms among the reproductive-age women in Chinese Han populations: based on migration.
  Shen Y, Gu Y, Tang Y, Shen H, Liu C. Shen Y, et al. BMC Womens Health. 2024 Jul 18;24(1):407. doi: 10.1186/s12905-024-03244-3. BMC Womens Health. 2024. PMID: 39026333 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Ovid Technologies, Inc.
  • Silverchair Information Systems

• Other Literature Sources

  • The Lens - Patent Citations

• Medical

  • MedlinePlus Health Information