Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300 - PubMed (original) (raw)

Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300

K Nakashima et al. Science. 1999.

Abstract

The cytokines LIF (leukemia inhibitory factor) and BMP2 (bone morphogenetic protein-2) signal through different receptors and transcription factors, namely STATs (signal transducers and activators of transcription) and Smads. LIF and BMP2 were found to act in synergy on primary fetal neural progenitor cells to induce astrocytes. The transcriptional coactivator p300 interacts physically with STAT3 at its amino terminus in a cytokine stimulation-independent manner, and with Smad1 at its carboxyl terminus in a cytokine stimulation-dependent manner. The formation of a complex between STAT3 and Smad1, bridged by p300, is involved in the cooperative signaling of LIF and BMP2 and the subsequent induction of astrocytes from neural progenitors.

PubMed Disclaimer

Comment in

• Nuclear fusion of signaling pathways.
  Janknecht R, Hunter T. Janknecht R, et al. Science. 1999 Apr 16;284(5413):443-4. doi: 10.1126/science.284.5413.443. Science. 1999. PMID: 10232991 No abstract available.

Similar articles

• Nuclear fusion of signaling pathways.
  Janknecht R, Hunter T. Janknecht R, et al. Science. 1999 Apr 16;284(5413):443-4. doi: 10.1126/science.284.5413.443. Science. 1999. PMID: 10232991 No abstract available.
• Signaling crosstalk underlying synergistic induction of astrocyte differentiation by BMPs and IL-6 family of cytokines.
  Yanagisawa M, Nakashima K, Takizawa T, Ochiai W, Arakawa H, Taga T. Yanagisawa M, et al. FEBS Lett. 2001 Feb 2;489(2-3):139-43. doi: 10.1016/s0014-5793(01)02095-6. FEBS Lett. 2001. PMID: 11165238
• Epidermal growth factor receptors control competence to interpret leukemia inhibitory factor as an astrocyte inducer in developing cortex.
  Viti J, Feathers A, Phillips J, Lillien L. Viti J, et al. J Neurosci. 2003 Apr 15;23(8):3385-93. doi: 10.1523/JNEUROSCI.23-08-03385.2003. J Neurosci. 2003. PMID: 12716946 Free PMC article.
• TGF-beta signaling by Smad proteins.
  Miyazono K. Miyazono K. Cytokine Growth Factor Rev. 2000 Mar-Jun;11(1-2):15-22. doi: 10.1016/s1359-6101(99)00025-8. Cytokine Growth Factor Rev. 2000. PMID: 10708949 Review.
• Cell fate determination regulated by a transcriptional signal network in the developing mouse brain.
  Fukuda S, Taga T. Fukuda S, et al. Anat Sci Int. 2005 Mar;80(1):12-8. doi: 10.1111/j.1447-073x.2005.00097.x. Anat Sci Int. 2005. PMID: 15794126 Review.

Cited by

• The dynamic role of bone morphogenetic proteins in neural stem cell fate and maturation.
  Bond AM, Bhalala OG, Kessler JA. Bond AM, et al. Dev Neurobiol. 2012 Jul;72(7):1068-84. doi: 10.1002/dneu.22022. Dev Neurobiol. 2012. PMID: 22489086 Free PMC article. Review.
• The novel monoclonal antibody 9F5 reveals expression of a fragment of GPNMB/osteoactivin processed by furin-like protease(s) in a subpopulation of microglia in neonatal rat brain.
  Kawahara K, Hirata H, Ohbuchi K, Nishi K, Maeda A, Kuniyasu A, Yamada D, Maeda T, Tsuji A, Sawada M, Nakayama H. Kawahara K, et al. Glia. 2016 Nov;64(11):1938-61. doi: 10.1002/glia.23034. Epub 2016 Jul 27. Glia. 2016. PMID: 27464357 Free PMC article.
• Human stem cell-derived astrocytes and their application to studying Nrf2-mediated neuroprotective pathways and therapeutics in neurodegeneration.
  Gupta K, Chandran S, Hardingham GE. Gupta K, et al. Br J Clin Pharmacol. 2013 Apr;75(4):907-18. doi: 10.1111/bcp.12022. Br J Clin Pharmacol. 2013. PMID: 23126226 Free PMC article. Review.
• leptin-induced growth stimulation of breast cancer cells involves recruitment of histone acetyltransferases and mediator complex to CYCLIN D1 promoter via activation of Stat3.
  Saxena NK, Vertino PM, Anania FA, Sharma D. Saxena NK, et al. J Biol Chem. 2007 May 4;282(18):13316-25. doi: 10.1074/jbc.M609798200. Epub 2007 Mar 7. J Biol Chem. 2007. PMID: 17344214 Free PMC article.
• Genome-wide mapping and analysis of active promoters in mouse embryonic stem cells and adult organs.
  Barrera LO, Li Z, Smith AD, Arden KC, Cavenee WK, Zhang MQ, Green RD, Ren B. Barrera LO, et al. Genome Res. 2008 Jan;18(1):46-59. doi: 10.1101/gr.6654808. Epub 2007 Nov 27. Genome Res. 2008. PMID: 18042645 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Atypon
  • Ovid Technologies, Inc.

• Other Literature Sources

  • The Lens - Patent Citations Database

• Molecular Biology Databases

  • BioCyc
  • Gene Ontology
  • Mouse Genome Informatics (MGI)

• Miscellaneous

  • NCI CPTAC Assay Portal