Striatal A2A adenosine receptors differentially regulate spontaneous and K+-evoked glutamate release in vivo in young and aged rats - PubMed (original) (raw)
Striatal A2A adenosine receptors differentially regulate spontaneous and K+-evoked glutamate release in vivo in young and aged rats
C Corsi et al. Neuroreport. 1999.
Abstract
The effect of the adenosine A2A receptor agonist CGS 21680 on glutamate and aspartate release was investigated in the striatum of young and old rats by microdialysis experiments. CGS 21680 (10 microM) significantly increased glutamate and aspartate spontaneous outflow in young but not in old rats. On the contrary, CGS 21680 induced the same decrease in K+-evoked glutamate outflow in both young and aged rats. A lower dose of CGS 21680 (1 microM) failed to modify either spontaneous or K+-evoked outflow. It is suggested that the opposite effects of the A2A agonist on excitatory amino acid outflow may be respectively mediated by striatal A2A adenosine receptors located on glutamatergic terminals and on the striatal indirect output pathway.
Similar articles
- Striatal A2A adenosine receptor antagonism differentially modifies striatal glutamate outflow in vivo in young and aged rats.
Corsi C, Melani A, Bianchi L, Pedata F. Corsi C, et al. Neuroreport. 2000 Aug 3;11(11):2591-5. doi: 10.1097/00001756-200008030-00048. Neuroreport. 2000. PMID: 10943728 - Adenosine A2A receptor stimulation enhances striatal extracellular glutamate levels in rats.
Popoli P, Betto P, Reggio R, Ricciarello G. Popoli P, et al. Eur J Pharmacol. 1995 Dec 12;287(2):215-7. doi: 10.1016/0014-2999(95)00679-6. Eur J Pharmacol. 1995. PMID: 8749040 - Effect of adenosine A2A receptor stimulation on GABA release from the striatum of young and aged rats in vivo.
Corsi C, Melani A, Bianchi L, Pepeu G, Pedata F. Corsi C, et al. Neuroreport. 1999 Dec 16;10(18):3933-7. doi: 10.1097/00001756-199912160-00038. Neuroreport. 1999. PMID: 10716236 - Adenosine extracellular brain concentrations and role of A2A receptors in ischemia.
Pedata F, Corsi C, Melani A, Bordoni F, Latini S. Pedata F, et al. Ann N Y Acad Sci. 2001 Jun;939:74-84. doi: 10.1111/j.1749-6632.2001.tb03614.x. Ann N Y Acad Sci. 2001. PMID: 11462806 Review. - Distribution, biochemistry and function of striatal adenosine A2A receptors.
Svenningsson P, Le Moine C, Fisone G, Fredholm BB. Svenningsson P, et al. Prog Neurobiol. 1999 Nov;59(4):355-96. doi: 10.1016/s0301-0082(99)00011-8. Prog Neurobiol. 1999. PMID: 10501634 Review.
Cited by
- Aging disrupts the coordination between mRNA and protein expression in mouse and human midbrain.
Buck SA, Mabry SJ, Glausier JR, Banks-Tibbs T, Ward C, Kozel JG, Fu C, Fish KN, Lewis DA, Logan RW, Freyberg Z. Buck SA, et al. bioRxiv [Preprint]. 2024 Jun 1:2024.06.01.596950. doi: 10.1101/2024.06.01.596950. bioRxiv. 2024. PMID: 38854057 Free PMC article. Preprint. - Stimulation of adenosine receptors in the nucleus accumbens reverses the expression of cocaine sensitization and cross-sensitization to dopamine D2 receptors in rats.
Hobson BD, Merritt KE, Bachtell RK. Hobson BD, et al. Neuropharmacology. 2012 Nov;63(6):1172-81. doi: 10.1016/j.neuropharm.2012.06.038. Epub 2012 Jun 28. Neuropharmacology. 2012. PMID: 22749927 Free PMC article. - Adenosine A2A receptors in the nucleus accumbens bi-directionally alter cocaine seeking in rats.
O'Neill CE, LeTendre ML, Bachtell RK. O'Neill CE, et al. Neuropsychopharmacology. 2012 Apr;37(5):1245-56. doi: 10.1038/npp.2011.312. Epub 2011 Dec 14. Neuropsychopharmacology. 2012. PMID: 22169945 Free PMC article. - Effects of adenosine A2A receptor stimulation on cocaine-seeking behavior in rats.
Bachtell RK, Self DW. Bachtell RK, et al. Psychopharmacology (Berl). 2009 Oct;206(3):469-78. doi: 10.1007/s00213-009-1624-2. Epub 2009 Jul 30. Psychopharmacology (Berl). 2009. PMID: 19641899 Free PMC article. - Adenosine transiently modulates stimulated dopamine release in the caudate-putamen via A1 receptors.
Ross AE, Venton BJ. Ross AE, et al. J Neurochem. 2015 Jan;132(1):51-60. doi: 10.1111/jnc.12946. Epub 2014 Oct 4. J Neurochem. 2015. PMID: 25219576 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Molecular Biology Databases