In or out? Regulating nuclear transport - PubMed (original) (raw)

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In or out? Regulating nuclear transport

J K Hood et al. Curr Opin Cell Biol. 1999 Apr.

Abstract

The compartmentalization of proteins within the nucleus or cytoplasm of a eukaryotic cell offers opportunity for regulation of cell cycle progression and signalling pathways. Nuclear localization of proteins is determined by their ability to interact with specific nuclear import and export factors. In the past year, substrate phosphorylation has emerged as a common mechanism for controlling this interaction.

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