Protein structural topology: Automated analysis and diagrammatic representation - PubMed (original) (raw)
Protein structural topology: Automated analysis and diagrammatic representation
D R Westhead et al. Protein Sci. 1999 Apr.
Abstract
The topology of a protein structure is a highly simplified description of its fold including only the sequence of secondary structure elements, and their relative spatial positions and approximate orientations. This information can be embodied in a two-dimensional diagram of protein topology, called a TOPS cartoon. These cartoons are useful for the understanding of particular folds and making comparisons between folds. Here we describe a new algorithm for the production of TOPS cartoons, which is more robust than those previously available, and has a much higher success rate. This algorithm has been used to produce a database of protein topology cartoons that covers most of the data bank of known protein structures.
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