Thermoregulatory cold-defense deficits in rats with preoptic/anterior hypothalamic lesions - PubMed (original) (raw)
Thermoregulatory cold-defense deficits in rats with preoptic/anterior hypothalamic lesions
E Satinoff et al. Brain Res Bull. 1976 Nov-Dec.
Abstract
This paper discusses the course of recovery from the thermoregulatory deficits produced in rats by electrolytic lesions in the preoptic/anterior hypothalamic area. Severe damage rendered rats ectothermic, that is unable to maintain their body temperatures at normal levels unless they were incubated at an ambient temperature of 30 degrees C. Less severe damage produced rats that maintained subnormal but stable body temperatures at 23 degrees C, but that did not increase metabolic rate or shiver and whose body temperatures dropped drastically in the cold (5 degrees C). As the animals recovered, nonshivering thermogenesis returned. Eventually the rats became excessively hyperthermic in normal room temperatures, due to very high metabolic rates. They were still unable to shiver or increase metabolic rate further in the cold and were therefore still unable to prevent a large drop in body temperature. Muscle tonus and shivering recovered gradually, and oxygen consumption returned to near normal levels. The data are described in terms of levels of integration of the nervous control of thermoregulation.
Similar articles
- Shivering and nonshivering thermogenic responses of cold-exposed rats to hypothalamic warming.
Fuller CA, Horwitz BA, Horowitz JM. Fuller CA, et al. Am J Physiol. 1975 May;228(5):1519-24. doi: 10.1152/ajplegacy.1975.228.5.1519. Am J Physiol. 1975. PMID: 1130555 - Lateral distribution of hypothalamic signals controlling thermoregulatory vasomotor activity and shivering in rats.
Kanosue K, Niwa K, Andrew PD, Yasuda H, Yanase M, Tanaka H, Matsumura K. Kanosue K, et al. Am J Physiol. 1991 Mar;260(3 Pt 2):R486-93. doi: 10.1152/ajpregu.1991.260.3.R486. Am J Physiol. 1991. PMID: 2000997 - Thermal homeostasis in rats after intrahypothalamic injections of 6-hyroxydopamine.
Van Zoeren JG, Stricker EM. Van Zoeren JG, et al. Am J Physiol. 1976 Apr;230(4):932-9. doi: 10.1152/ajplegacy.1976.230.4.932. Am J Physiol. 1976. PMID: 1267027 - Role of the preoptic-anterior hypothalamus in thermoregulation and fever.
Boulant JA. Boulant JA. Clin Infect Dis. 2000 Oct;31 Suppl 5:S157-61. doi: 10.1086/317521. Clin Infect Dis. 2000. PMID: 11113018 Review. - Determinants of hypothalamic neuronal thermosensitivity.
Boulant JA, Chow AR, Griffin JD. Boulant JA, et al. Ann N Y Acad Sci. 1997 Mar 15;813:133-8. doi: 10.1111/j.1749-6632.1997.tb51684.x. Ann N Y Acad Sci. 1997. PMID: 9100874 Review. No abstract available.
Cited by
- The Role of Thermosensitive Ion Channels in Mammalian Thermoregulation.
Chen Y, Song K. Chen Y, et al. Adv Exp Med Biol. 2021;1349:355-370. doi: 10.1007/978-981-16-4254-8_16. Adv Exp Med Biol. 2021. PMID: 35138622 - Role of the Preoptic Area in Sleep and Thermoregulation.
Rothhaas R, Chung S. Rothhaas R, et al. Front Neurosci. 2021 Jul 1;15:664781. doi: 10.3389/fnins.2021.664781. eCollection 2021. Front Neurosci. 2021. PMID: 34276287 Free PMC article. Review. - Parabrachial opioidergic projections to preoptic hypothalamus mediate behavioral and physiological thermal defenses.
Norris AJ, Shaker JR, Cone AL, Ndiokho IB, Bruchas MR. Norris AJ, et al. Elife. 2021 Mar 5;10:e60779. doi: 10.7554/eLife.60779. Elife. 2021. PMID: 33667158 Free PMC article. - Regulation of Body Temperature by the Nervous System.
Tan CL, Knight ZA. Tan CL, et al. Neuron. 2018 Apr 4;98(1):31-48. doi: 10.1016/j.neuron.2018.02.022. Neuron. 2018. PMID: 29621489 Free PMC article. Review. - Hypothalamic-autonomic control of energy homeostasis.
Seoane-Collazo P, Fernø J, Gonzalez F, Diéguez C, Leis R, Nogueiras R, López M. Seoane-Collazo P, et al. Endocrine. 2015 Nov;50(2):276-91. doi: 10.1007/s12020-015-0658-y. Epub 2015 Jun 19. Endocrine. 2015. PMID: 26089260 Review.
MeSH terms
LinkOut - more resources
Full Text Sources
Research Materials