Long-term treatment with eicosapentaenoic acid augments both nitric oxide-mediated and non-nitric oxide-mediated endothelium-dependent forearm vasodilatation in patients with coronary artery disease - PubMed (original) (raw)
Long-term treatment with eicosapentaenoic acid augments both nitric oxide-mediated and non-nitric oxide-mediated endothelium-dependent forearm vasodilatation in patients with coronary artery disease
H Tagawa et al. J Cardiovasc Pharmacol. 1999 Apr.
Abstract
Long-term treatment with eicosapentaenoic acid (EPA) is known to improve impaired endothelium-dependent relaxations of atherosclerotic blood vessels in animals and humans. However, it remains to be determined which mechanisms are involved in this beneficial effect of EPA. In this study, we investigated our hypothesis that EPA improves both nitric oxide (NO)-mediated and non-NO-mediated endothelium-dependent vasodilatation in patients with coronary artery disease. The study included eight patients with documented coronary artery disease. The forearm vascular responses to the endothelium-dependent vasodilator acetylcholine and substance P were examined before and after intraarterial infusion of NG-monomethyl-L-arginine (L-NMMA). Same measurements were repeated after the treatment with EPA (1,800 mg/day) for 6 weeks. The long-term treatment with EPA augmented forearm blood-flow response to both acetylcholine and substance P. Furthermore, acute administration of L-NMMA significantly inhibited the EPA-induced augmented response to acetylcholine but not that to substance P. The forearm vascular response to sodium nitroprusside was unchanged by the EPA treatment. These results indicate that long-term treatment with EPA augments both NO-dependent and non-NO-dependent endothelium-dependent forearm vasodilatation in patients with coronary artery disease. Thus the beneficial effects of EPA appear to extend to non-NO-dependent mechanism(s).
Similar articles
- Long-term treatment with eicosapentaenoic acid improves exercise-induced vasodilation in patients with coronary artery disease.
Tagawa T, Hirooka Y, Shimokawa H, Hironaga K, Sakai K, Oyama J, Takeshita A. Tagawa T, et al. Hypertens Res. 2002 Nov;25(6):823-9. doi: 10.1291/hypres.25.823. Hypertens Res. 2002. PMID: 12484504 - Short-term estrogen augments both nitric oxide-mediated and non-nitric oxide-mediated endothelium-dependent forearm vasodilation in postmenopausal women.
Tagawa H, Shimokawa H, Tagawa T, Kuroiwa-Matsumoto M, Hirooka Y, Takeshita A. Tagawa H, et al. J Cardiovasc Pharmacol. 1997 Oct;30(4):481-8. doi: 10.1097/00005344-199710000-00012. J Cardiovasc Pharmacol. 1997. PMID: 9335408 - Does lipoprotein(a) impair endothelial function?
Schlaich MP, John S, Langenfeld MR, Lackner KJ, Schmitz G, Schmieder RE. Schlaich MP, et al. J Am Coll Cardiol. 1998 Feb;31(2):359-65. doi: 10.1016/s0735-1097(97)00497-x. J Am Coll Cardiol. 1998. PMID: 9462580 - Beneficial effects of eicosapentaenoic acid on endothelial vasodilator functions in animals and humans.
Shimokawa H. Shimokawa H. World Rev Nutr Diet. 2001;88:100-8. doi: 10.1159/000059773. World Rev Nutr Diet. 2001. PMID: 11935942 Review. No abstract available. - Evaluation of endothelium-dependent vasodilation in humans.
Lind L. Lind L. Blood Press. 2001;10(3):124-30. doi: 10.1080/080370501753182325. Blood Press. 2001. PMID: 11688758 Review.
Cited by
- Characterisation of the vasodilation effects of DHA and EPA, n-3 PUFAs (fish oils), in rat aorta and mesenteric resistance arteries.
Limbu R, Cottrell GS, McNeish AJ. Limbu R, et al. PLoS One. 2018 Feb 2;13(2):e0192484. doi: 10.1371/journal.pone.0192484. eCollection 2018. PLoS One. 2018. PMID: 29394279 Free PMC article. - Role of omega-3 fatty acids in obesity, metabolic syndrome, and cardiovascular diseases: a review of the evidence.
Lorente-Cebrián S, Costa AG, Navas-Carretero S, Zabala M, Martínez JA, Moreno-Aliaga MJ. Lorente-Cebrián S, et al. J Physiol Biochem. 2013 Sep;69(3):633-51. doi: 10.1007/s13105-013-0265-4. Epub 2013 Jun 22. J Physiol Biochem. 2013. PMID: 23794360 Review. - Activity of Bradykinin B2 Receptor Is Regulated by Long-Chain Polyunsaturated Fatty Acids.
Candelario J, Chachisvilis M. Candelario J, et al. PLoS One. 2013 Jun 27;8(6):e68151. doi: 10.1371/journal.pone.0068151. Print 2013. PLoS One. 2013. PMID: 23826374 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials