The intravenous model of murine tuberculosis is less pathogenic than the aerogenic model owing to a more rapid induction of systemic immunity - PubMed (original) (raw)

Comparative Study

The intravenous model of murine tuberculosis is less pathogenic than the aerogenic model owing to a more rapid induction of systemic immunity

P J Cardona et al. Scand J Immunol. 1999 Apr.

Free article

Abstract

The detection of mRNA in the murine model of tuberculosis for key cytokines involved in protective immunity in the lung tissues revealed a much faster emergence of the interferon (IFN)-gamma response in the intravenous route than in the aerosol route of inoculation. This slower response in the lungs was associated with a stronger inflammatory response, resulting in large granulomatous structures and eventual tissue damage.

PubMed Disclaimer

Cited by

Mouse Models for Mycobacterium tuberculosis Pathogenesis: Show and Do Not Tell.
Soldevilla P, Vilaplana C, Cardona PJ. Soldevilla P, et al. Pathogens. 2022 Dec 28;12(1):49. doi: 10.3390/pathogens12010049. Pathogens. 2022. PMID: 36678397 Free PMC article. Review.
Cording Mycobacterium tuberculosis Bacilli Have a Key Role in the Progression towards Active Tuberculosis, Which is Stopped by Previous Immune Response.
Arias L, Cardona P, Català M, Campo-Pérez V, Prats C, Vilaplana C, Julián E, Cardona PJ. Arias L, et al. Microorganisms. 2020 Feb 8;8(2):228. doi: 10.3390/microorganisms8020228. Microorganisms. 2020. PMID: 32046344 Free PMC article.
Enhanced Delivery of 4-Thioureidoiminomethylpyridinium Perchlorate in Tuberculosis Models with IgG Functionalized Poly(Lactic Acid)-Based Particles.
Churilov L, Korzhikov-Vlakh V, Sinitsyna E, Polyakov D, Darashkevich O, Poida M, Platonova G, Vinogradova T, Utekhin V, Zabolotnykh N, Zinserling V, Yablonsky P, Urtti A, Tennikova T. Churilov L, et al. Pharmaceutics. 2018 Dec 21;11(1):2. doi: 10.3390/pharmaceutics11010002. Pharmaceutics. 2018. PMID: 30577686 Free PMC article.
Specific T cell induction using iron oxide based nanoparticles as subunit vaccine adjuvant.
Neto LMM, Zufelato N, de Sousa-Júnior AA, Trentini MM, da Costa AC, Bakuzis AF, Kipnis A, Junqueira-Kipnis AP. Neto LMM, et al. Hum Vaccin Immunother. 2018;14(11):2786-2801. doi: 10.1080/21645515.2018.1489192. Epub 2018 Jul 12. Hum Vaccin Immunother. 2018. PMID: 29913109 Free PMC article.
What We Have Learned and What We Have Missed in Tuberculosis Pathophysiology for a New Vaccine Design: Searching for the "Pink Swan".
Cardona PJ. Cardona PJ. Front Immunol. 2017 May 15;8:556. doi: 10.3389/fimmu.2017.00556. eCollection 2017. Front Immunol. 2017. PMID: 28555137 Free PMC article. Review.

The intravenous model of murine tuberculosis is less pathogenic than the aerogenic model owing to a more rapid induction of systemic immunity - PubMed (original) (raw)