Cutting edge: HLA-B27 can form a novel beta 2-microglobulin-free heavy chain homodimer structure - PubMed (original) (raw)
. 1999 May 1;162(9):5045-8.
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- PMID: 10227970
Cutting edge: HLA-B27 can form a novel beta 2-microglobulin-free heavy chain homodimer structure
R L Allen et al. J Immunol. 1999.
Abstract
HLA-B27 has a striking association with inflammatory arthritis. We show that free HLA-B27 heavy chains can form a disulfide-bonded homodimer, dependent on residue Cys67 in their extracellular alpha 1 domain. Despite the absence of beta 2-microglobulin, HLA-B27 heavy chain homodimers (termed HC-B27) were stabilized by a known peptide epitope. HC-B27 complexes were recognized by the conformation-specific Ab W6/32, but not the ME1 Ab. Surface labeling and immunoprecipitation demonstrated the presence of similar W6/32-reactive free heavy chains at the surface of HLA-B27-transfected T2 cells. HC-B27 homodimer formation might explain the ability of HLA-B27 to induce spondyloarthropathy in beta 2-microglobulin-deficient mice.
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