The PIK-related kinases intercept conventional signaling pathways - PubMed (original) (raw)

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The PIK-related kinases intercept conventional signaling pathways

F G Kuruvilla et al. Chem Biol. 1999 May.

Abstract

Early efforts to place the first cloned mammalian PIK-related kinase, FRAP, into a conventional membrane to nuclear pathway met with little success. More recent data suggest that members of the family of PIK-related kinases act as intracellular sensors that govern radial and horizontal pathways. These pathways can impinge upon classical membrane to nuclear pathways, as well as components of the cell-cycle machinery.

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