DNA methylation and chromatin modification - PubMed (original) (raw)
Review
DNA methylation and chromatin modification
H H Ng et al. Curr Opin Genet Dev. 1999 Apr.
Abstract
DNA methylation and chromatin modification are two global mechanisms that regulate gene expression. Recent studies provide insight into the mechanism of transcriptional silencing by a methyl-CpG binding protein, MeCP2. MeCP2 is shown to interact with the Sin3/histone deacetylase co-repressor complex. Thus, this interaction can provide a mechanistic explanation for the long-known relationship between DNA methylation and chromatin structure. Moreover, several studies have shown that inhibition of histone deacetylases by specific inhibitors can reactivate endogenous genes or reporter constructs previously silenced by DNA methylation. Taken together, the data strongly suggest that DNA methylation can pattern chromatin modification.
Similar articles
- Heterogeneity in the modification and involvement of chromatin components of the CpG island of the silenced human CDH1 gene in cancer cells.
Koizume S, Tachibana K, Sekiya T, Hirohashi S, Shiraishi M. Koizume S, et al. Nucleic Acids Res. 2002 Nov 1;30(21):4770-80. doi: 10.1093/nar/gkf593. Nucleic Acids Res. 2002. PMID: 12409468 Free PMC article. - Altered chromatin structure associated with methylation-induced gene silencing in cancer cells: correlation of accessibility, methylation, MeCP2 binding and acetylation.
Nguyen CT, Gonzales FA, Jones PA. Nguyen CT, et al. Nucleic Acids Res. 2001 Nov 15;29(22):4598-606. doi: 10.1093/nar/29.22.4598. Nucleic Acids Res. 2001. PMID: 11713309 Free PMC article. - Transcriptional gene silencing promotes DNA hypermethylation through a sequential change in chromatin modifications in cancer cells.
Stirzaker C, Song JZ, Davidson B, Clark SJ. Stirzaker C, et al. Cancer Res. 2004 Jun 1;64(11):3871-7. doi: 10.1158/0008-5472.CAN-03-3690. Cancer Res. 2004. PMID: 15172996 - Co-repressor complexes and remodelling chromatin for repression.
Wolffe AP, Urnov FD, Guschin D. Wolffe AP, et al. Biochem Soc Trans. 2000;28(4):379-86. Biochem Soc Trans. 2000. PMID: 10961924 Review. - Emerging connections between DNA methylation and histone acetylation.
Dobosy JR, Selker EU. Dobosy JR, et al. Cell Mol Life Sci. 2001 May;58(5-6):721-7. doi: 10.1007/pl00000895. Cell Mol Life Sci. 2001. PMID: 11437233 Free PMC article. Review.
Cited by
- Genomic factors associated with substance use disorder relapse: A critical review.
Al-Marzooqi N, Al-Suhail H, AlRefai MO, Alhaj HA. Al-Marzooqi N, et al. Addict Behav Rep. 2024 Oct 30;20:100569. doi: 10.1016/j.abrep.2024.100569. eCollection 2024 Dec. Addict Behav Rep. 2024. PMID: 39553284 Free PMC article. Review. - Phenotypic plasticity for improved light harvesting, in tandem with methylome repatterning in reef-building corals.
Gomez-Campo K, Sanchez R, Martinez-Rugerio I, Yang X, Maher T, Osborne CC, Enriquez S, Baums IB, Mackenzie SA, Iglesias-Prieto R. Gomez-Campo K, et al. Mol Ecol. 2024 Feb;33(4):e17246. doi: 10.1111/mec.17246. Epub 2023 Dec 28. Mol Ecol. 2024. PMID: 38153177 - Editorial: New insights into mechanisms of epigenetic modifiers in plant growth and development, volume II.
Luo M, Sarnowski TJ, Libault M, Ríos G, Charron JB, Mantri N, Zhang S. Luo M, et al. Front Plant Sci. 2023 Jun 20;14:1213511. doi: 10.3389/fpls.2023.1213511. eCollection 2023. Front Plant Sci. 2023. PMID: 37409285 Free PMC article. No abstract available. - Methylation pattern and mRNA expression of synapse-relevant genes in the MAM model of schizophrenia in the time-course of adolescence.
Khan AQ, Thielen L, Le Pen G, Krebs MO, Kebir O, Groh A, Deest M, Bleich S, Frieling H, Jahn K. Khan AQ, et al. Schizophrenia (Heidelb). 2022 Dec 8;8(1):110. doi: 10.1038/s41537-022-00319-8. Schizophrenia (Heidelb). 2022. PMID: 36481661 Free PMC article. - Development of DNA methylation-based epigenetic age predictors in loblolly pine (Pinus taeda).
Gardner ST, Bertucci EM, Sutton R, Horcher A, Aubrey D, Parrott BB. Gardner ST, et al. Mol Ecol Resour. 2023 Jan;23(1):131-144. doi: 10.1111/1755-0998.13698. Epub 2022 Aug 24. Mol Ecol Resour. 2023. PMID: 35957540 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Other Literature Sources