Tripartite synapses: glia, the unacknowledged partner - PubMed (original) (raw)
Review
Tripartite synapses: glia, the unacknowledged partner
A Araque et al. Trends Neurosci. 1999 May.
Abstract
According to the classical view of the nervous system, the numerically superior glial cells have inferior roles in that they provide an ideal environment for neuronal-cell function. However, there is a wave of new information suggesting that glia are intimately involved in the active control of neuronal activity and synaptic neurotransmission. Recent evidence shows that glia respond to neuronal activity with an elevation of their internal Ca2+ concentration, which triggers the release of chemical transmitters from glia themselves and, in turn, causes feedback regulation of neuronal activity and synaptic strength. In view of these new insights, this article suggests that perisynaptic Schwann cells and synaptically associated astrocytes should be viewed as integral modulatory elements of tripartite synapses.
Similar articles
- GLIA modulates synaptic transmission.
Perea G, Araque A. Perea G, et al. Brain Res Rev. 2010 May;63(1-2):93-102. doi: 10.1016/j.brainresrev.2009.10.005. Epub 2009 Nov 6. Brain Res Rev. 2010. PMID: 19896978 Review. - Imbalance of glial-neuronal interaction in synapses: a possible mechanism of the pathophysiology of bipolar disorder.
Mitterauer B. Mitterauer B. Neuroscientist. 2004 Jun;10(3):199-206. doi: 10.1177/107385403262248. Neuroscientist. 2004. PMID: 15155059 Review. - GLIA: listening and talking to the synapse.
Haydon PG. Haydon PG. Nat Rev Neurosci. 2001 Mar;2(3):185-93. doi: 10.1038/35058528. Nat Rev Neurosci. 2001. PMID: 11256079 Review. - Glial cells in synaptic plasticity.
Todd KJ, Serrano A, Lacaille JC, Robitaille R. Todd KJ, et al. J Physiol Paris. 2006 Mar-May;99(2-3):75-83. doi: 10.1016/j.jphysparis.2005.12.002. Epub 2006 Jan 30. J Physiol Paris. 2006. PMID: 16446078 Review. - Glial calcium signaling and neuron-glia communication.
Perea G, Araque A. Perea G, et al. Cell Calcium. 2005 Sep-Oct;38(3-4):375-82. doi: 10.1016/j.ceca.2005.06.015. Cell Calcium. 2005. PMID: 16105683 Review.
Cited by
- The endocannabinoid system in the amygdala and modulation of fear.
Gunduz-Cinar O. Gunduz-Cinar O. Prog Neuropsychopharmacol Biol Psychiatry. 2021 Mar 8;105:110116. doi: 10.1016/j.pnpbp.2020.110116. Epub 2020 Sep 23. Prog Neuropsychopharmacol Biol Psychiatry. 2021. PMID: 32976951 Free PMC article. Review. - Excitable Astrocytes: Ca(2+)- and cAMP-Regulated Exocytosis.
Vardjan N, Zorec R. Vardjan N, et al. Neurochem Res. 2015 Dec;40(12):2414-24. doi: 10.1007/s11064-015-1545-x. Epub 2015 Mar 3. Neurochem Res. 2015. PMID: 25732760 Review. - Serotonin Attenuates Feedback Excitation onto O-LM Interneurons.
Böhm C, Pangalos M, Schmitz D, Winterer J. Böhm C, et al. Cereb Cortex. 2015 Nov;25(11):4572-83. doi: 10.1093/cercor/bhv098. Epub 2015 May 28. Cereb Cortex. 2015. PMID: 26021702 Free PMC article. - Glial restricted precursor cells in central nervous system disorders: Current applications and future perspectives.
Martins-Macedo J, Lepore AC, Domingues HS, Salgado AJ, Gomes ED, Pinto L. Martins-Macedo J, et al. Glia. 2021 Mar;69(3):513-531. doi: 10.1002/glia.23922. Epub 2020 Oct 14. Glia. 2021. PMID: 33052610 Free PMC article. Review. - Role of hydrogen sulfide in brain synaptic remodeling.
Kamat PK, Kalani A, Tyagi N. Kamat PK, et al. Methods Enzymol. 2015;555:207-29. doi: 10.1016/bs.mie.2014.11.025. Epub 2015 Jan 13. Methods Enzymol. 2015. PMID: 25747482 Free PMC article. Review.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous