HOX11 interacts with CTF1 and mediates hematopoietic precursor cell immortalization - PubMed (original) (raw)
Comparative Study
. 1999 Apr 1;18(13):2273-9.
doi: 10.1038/sj.onc.1202545.
Affiliations
- PMID: 10327073
- DOI: 10.1038/sj.onc.1202545
Comparative Study
HOX11 interacts with CTF1 and mediates hematopoietic precursor cell immortalization
N Zhang et al. Oncogene. 1999.
Abstract
HOX11 is a homeodomain-containing oncogenic transcription factor that immortalizes hematopoietic precursor cells. The mechanism by which HOX11 facilitates this initial step of leukemogenesis is, however, not well understood. We have used a DNA binding site selection assay to investigate cooperative DNA binding by HOX11 with other transcription factors. A consensus sequence was derived and identified as the binding site for the CCAAT-box-binding transcription factors (CTF). HOX11 was shown to interact in vitro and in vivo with CTF1. Retrovirus-mediated transduction of an antisense CTF1 cDNA dramatically reduced the proliferative capacity of HOX11-immortalized hematopoietic precursor cells. CTF1 is, therefore, the first HOX11 protein partner identified that plays an important role in hematopoietic precursor cell immortalization.
Similar articles
- A complex containing PBX2 contributes to activation of the proto-oncogene HOX11.
Brake RL, Kees UR, Watt PM. Brake RL, et al. Biochem Biophys Res Commun. 2002 May 31;294(1):23-34. doi: 10.1016/S0006-291X(02)00426-6. Biochem Biophys Res Commun. 2002. PMID: 12054735 - HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint.
Kawabe T, Muslin AJ, Korsmeyer SJ. Kawabe T, et al. Nature. 1997 Jan 30;385(6615):454-8. doi: 10.1038/385454a0. Nature. 1997. PMID: 9009195 - The HOX11 homeobox-containing gene of human leukemia immortalizes murine hematopoietic precursors.
Hawley RG, Fong AZ, Lu M, Hawley TS. Hawley RG, et al. Oncogene. 1994 Jan;9(1):1-12. Oncogene. 1994. PMID: 7905617 - TALE homeoproteins as HOX11-interacting partners in T-cell leukemia.
Allen TD, Zhu YX, Hawley TS, Hawley RG. Allen TD, et al. Leuk Lymphoma. 2000 Oct;39(3-4):241-56. doi: 10.3109/10428190009065824. Leuk Lymphoma. 2000. PMID: 11342305 Review. - Insertional mutagenesis and the transformation of hematopoietic stem cells.
Askew DS, Bartholomew C, Ihle JN. Askew DS, et al. Hematol Pathol. 1993;7(1):1-22. Hematol Pathol. 1993. PMID: 8385659 Review. No abstract available.
Cited by
- Three Biomarkers Predict Gastric Cancer Patients' Susceptibility To Fluorouracil-based Chemotherapy.
Pan J, Dai Q, Xiang Z, Liu B, Li C. Pan J, et al. J Cancer. 2019 Jun 2;10(13):2953-2960. doi: 10.7150/jca.31120. eCollection 2019. J Cancer. 2019. PMID: 31281472 Free PMC article. - The DN2 Myeloid-T (DN2mt) Progenitor is a Target Cell for Leukemic Transformation by the TLX1 Oncogene.
Zweier-Renn LA, Riz I, Hawley TS, Hawley RG. Zweier-Renn LA, et al. J Bone Marrow Res. 2013 Feb 20;1:105. doi: 10.4172/2329-8820.1000105. J Bone Marrow Res. 2013. PMID: 25309961 Free PMC article. - Lentiviral fluorescent protein expression vectors for biotinylation proteomics.
Riz I, Hawley TS, Hawley RG. Riz I, et al. Methods Mol Biol. 2011;699:431-47. doi: 10.1007/978-1-61737-950-5_21. Methods Mol Biol. 2011. PMID: 21116996 Free PMC article. - High-resolution genome-wide in vivo footprinting of diverse transcription factors in human cells.
Boyle AP, Song L, Lee BK, London D, Keefe D, Birney E, Iyer VR, Crawford GE, Furey TS. Boyle AP, et al. Genome Res. 2011 Mar;21(3):456-64. doi: 10.1101/gr.112656.110. Epub 2010 Nov 24. Genome Res. 2011. PMID: 21106903 Free PMC article. - Phosphorylation of HOX11/TLX1 on Threonine-247 during mitosis modulates expression of cyclin B1.
Chen E, Huang X, Zheng Y, Li YJ, Chesney A, Ben-David Y, Yang E, Hough MR. Chen E, et al. Mol Cancer. 2010 Sep 16;9:246. doi: 10.1186/1476-4598-9-246. Mol Cancer. 2010. PMID: 20846384 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical