The zebrafish detour gene is essential for cranial but not spinal motor neuron induction - PubMed (original) (raw)
The zebrafish detour gene is essential for cranial but not spinal motor neuron induction
A Chandrasekhar et al. Development. 1999 Jun.
Abstract
The zebrafish detour (dtr) mutation generates a novel neuronal phenotype. In dtr mutants, most cranial motor neurons, especially the branchiomotor, are missing. However, spinal motor neurons are generated normally. The loss of cranial motor neurons is not due to aberrant hindbrain patterning, failure of neurogenesis, increased cell death or absence of hh expression. Furthermore, activation of the Hh pathway, which normally induces branchiomotor neurons, fails to induce motor neurons in the dtr hindbrain. Despite this, not all Hh-mediated regulation of hindbrain development is abolished since the regulation of a neural gene by Hh is intact in the dtr hindbrain. Finally, dtr can function cell autonomously to induce branchiomotor neurons. These results suggest that detour encodes a component of the Hh signaling pathway that is essential for the induction of motor neurons in the hindbrain but not in the spinal cord and that dtr function is required for the induction of only a subset of Hh-mediated events in the hindbrain.
Similar articles
- Gli function is essential for motor neuron induction in zebrafish.
Vanderlaan G, Tyurina OV, Karlstrom RO, Chandrasekhar A. Vanderlaan G, et al. Dev Biol. 2005 Jun 15;282(2):550-70. doi: 10.1016/j.ydbio.2005.04.010. Dev Biol. 2005. PMID: 15890329 Free PMC article. - Role of sonic hedgehog in branchiomotor neuron induction in zebrafish.
Chandrasekhar A, Warren JT Jr, Takahashi K, Schauerte HE, van Eeden FJ, Haffter P, Kuwada JY. Chandrasekhar A, et al. Mech Dev. 1998 Aug;76(1-2):101-15. doi: 10.1016/s0925-4773(98)00101-4. Mech Dev. 1998. PMID: 9767138 - Development of branchiomotor neurons in zebrafish.
Chandrasekhar A, Moens CB, Warren JT Jr, Kimmel CB, Kuwada JY. Chandrasekhar A, et al. Development. 1997 Jul;124(13):2633-44. doi: 10.1242/dev.124.13.2633. Development. 1997. PMID: 9217005 - Neuronal patterning: Making stripes in the spinal cord.
Goulding M, Lamar E. Goulding M, et al. Curr Biol. 2000 Jul 27-Aug 10;10(15):R565-8. doi: 10.1016/s0960-9822(00)00615-1. Curr Biol. 2000. PMID: 10959831 Review. No abstract available. - Moving cell bodies: understanding the migratory mechanism of facial motor neurons.
Song MR. Song MR. Arch Pharm Res. 2007 Oct;30(10):1273-82. doi: 10.1007/BF02980268. Arch Pharm Res. 2007. PMID: 18038906 Review.
Cited by
- Increased Netrin downstream of overactive Hedgehog signaling disrupts optic fissure formation.
Lusk S, LaPotin S, Presnell JS, Kwan KM. Lusk S, et al. bioRxiv [Preprint]. 2024 Jun 22:2024.06.18.599642. doi: 10.1101/2024.06.18.599642. bioRxiv. 2024. PMID: 38948711 Free PMC article. Updated. Preprint. - The developmental hourglass model is applicable to the spinal cord based on single-cell transcriptomes and non-conserved cis-regulatory elements.
Mukaigasa K, Sakuma C, Yaginuma H. Mukaigasa K, et al. Dev Growth Differ. 2021 Sep;63(7):372-391. doi: 10.1111/dgd.12750. Dev Growth Differ. 2021. PMID: 34473348 Free PMC article. - Elongator Subunit 3 (Elp3) Is Required for Zebrafish Trunk Development.
Rojas-Benítez D, Allende ML. Rojas-Benítez D, et al. Int J Mol Sci. 2020 Jan 31;21(3):925. doi: 10.3390/ijms21030925. Int J Mol Sci. 2020. PMID: 32023806 Free PMC article. - Role of branchiomotor neurons in controlling food intake of zebrafish larvae.
Allen JR, Bhattacharyya KD, Asante E, Almadi B, Schafer K, Davis J, Cox J, Voigt M, Viator JA, Chandrasekhar A. Allen JR, et al. J Neurogenet. 2017 Sep;31(3):128-137. doi: 10.1080/01677063.2017.1358270. Epub 2017 Aug 16. J Neurogenet. 2017. PMID: 28812416 Free PMC article. - Targeted inactivation and identification of targets of the Gli2a transcription factor in the zebrafish.
Wang X, Zhao Z, Muller J, Iyu A, Khng AJ, Guccione E, Ruan Y, Ingham PW. Wang X, et al. Biol Open. 2013 Sep 9;2(11):1203-13. doi: 10.1242/bio.20136262. eCollection 2013. Biol Open. 2013. PMID: 24244857 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Molecular Biology Databases