GABA(A) and GABA(B) antagonists differentially affect the firing pattern of substantia nigra dopaminergic neurons in vivo - PubMed (original) (raw)
Comparative Study
GABA(A) and GABA(B) antagonists differentially affect the firing pattern of substantia nigra dopaminergic neurons in vivo
C A Paladini et al. Synapse. 1999.
Abstract
The effects of local pressure application of the selective GABA(A) antagonists, bicuculline, gabazine, and picrotoxin, and the selective GABA(B) antagonists, 2-OH-saclofen and CGP-55845A, on the spontaneous activity of electrophysiologically identified substantia nigra dopaminergic neurons were recorded in vivo in urethane anesthetized rats. Blockade of GABA(A) inputs by bicuculline powerfully and reversibly induced burst firing in dopaminergic neurons along with a modest (25%) increase in firing rate, but the increase in burst firing was not correlated with the increase in firing rate. Picrotoxin and gabazine also produced an increase in burst firing without an increase in firing rate. In contrast, local application of GABA(B) antagonists did not produce bursting but rather caused a modest shift to a more regular firing pattern in 50% of the cases. These data demonstrate that dopaminergic neurons in vivo are under tonic GABAergic inhibition mediated by GABA(A) receptors and suggest that GABAergic afferents to substantia nigra comprise a major pathway by which the firing pattern of dopaminergic neurons is controlled in vivo.
Similar articles
- Striatal, pallidal, and pars reticulata evoked inhibition of nigrostriatal dopaminergic neurons is mediated by GABA(A) receptors in vivo.
Paladini CA, Celada P, Tepper JM. Paladini CA, et al. Neuroscience. 1999 Mar;89(3):799-812. doi: 10.1016/s0306-4522(98)00355-8. Neuroscience. 1999. PMID: 10199614 - GABAergic control of rat substantia nigra dopaminergic neurons: role of globus pallidus and substantia nigra pars reticulata.
Celada P, Paladini CA, Tepper JM. Celada P, et al. Neuroscience. 1999 Mar;89(3):813-25. doi: 10.1016/s0306-4522(98)00356-x. Neuroscience. 1999. PMID: 10199615 - GABA(B) receptor-mediated modulation of the firing pattern of ventral tegmental area dopamine neurons in vivo.
Erhardt S, Mathé JM, Chergui K, Engberg G, Svensson TH. Erhardt S, et al. Naunyn Schmiedebergs Arch Pharmacol. 2002 Mar;365(3):173-80. doi: 10.1007/s00210-001-0519-5. Epub 2002 Feb 6. Naunyn Schmiedebergs Arch Pharmacol. 2002. PMID: 11882912 - GABAergic control of substantia nigra dopaminergic neurons.
Tepper JM, Lee CR. Tepper JM, et al. Prog Brain Res. 2007;160:189-208. doi: 10.1016/S0079-6123(06)60011-3. Prog Brain Res. 2007. PMID: 17499115 Review. - Afferent modulation of dopamine neuron firing patterns.
Kitai ST, Shepard PD, Callaway JC, Scroggs R. Kitai ST, et al. Curr Opin Neurobiol. 1999 Dec;9(6):690-7. doi: 10.1016/s0959-4388(99)00040-9. Curr Opin Neurobiol. 1999. PMID: 10607649 Review.
Cited by
- LH-Nts Neurons Regulate VTA Calcium Dynamics Via Releasing GABA and Nts.
Chen D, Yuan Y, Huang Z, Wang Y. Chen D, et al. Neurosci Bull. 2024 Apr;40(4):550-552. doi: 10.1007/s12264-024-01181-7. Epub 2024 Feb 28. Neurosci Bull. 2024. PMID: 38416271 No abstract available. - Developmental exposure to the Parkinson's disease-associated organochlorine pesticide dieldrin alters dopamine neurotransmission in α-synuclein pre-formed fibril (PFF)-injected mice.
Boyd SL, Kuhn NC, Patterson JR, Stoll AC, Zimmerman SA, Kolanowski MR, Neubecker JJ, Luk KC, Ramsson ES, Sortwell CE, Bernstein AI. Boyd SL, et al. Toxicol Sci. 2023 Oct 30;196(1):99-111. doi: 10.1093/toxsci/kfad086. Toxicol Sci. 2023. PMID: 37607008 Free PMC article. - Netrin-1 regulates the balance of synaptic glutamate signaling in the adult ventral tegmental area.
Cline MM, Juarez B, Hunker A, Regiarto EG, Hariadi B, Soden ME, Zweifel LS. Cline MM, et al. Elife. 2023 Mar 17;12:e83760. doi: 10.7554/eLife.83760. Elife. 2023. PMID: 36927614 Free PMC article. - Dendritic involvement in inhibition and disinhibition of vulnerable dopaminergic neurons in healthy and pathological conditions.
Evans RC. Evans RC. Neurobiol Dis. 2022 Oct 1;172:105815. doi: 10.1016/j.nbd.2022.105815. Epub 2022 Jul 9. Neurobiol Dis. 2022. PMID: 35820645 Free PMC article. Review. - Axonal Modulation of Striatal Dopamine Release by Local γ-Aminobutyric Acid (GABA) Signalling.
Roberts BM, Lopes EF, Cragg SJ. Roberts BM, et al. Cells. 2021 Mar 23;10(3):709. doi: 10.3390/cells10030709. Cells. 2021. PMID: 33806845 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources