Genetics of mouse behavior: interactions with laboratory environment - PubMed (original) (raw)

Comparative Study

. 1999 Jun 4;284(5420):1670-2.

doi: 10.1126/science.284.5420.1670.

Affiliations

• PMID: 10356397
• DOI: 10.1126/science.284.5420.1670

Comparative Study

Genetics of mouse behavior: interactions with laboratory environment

J C Crabbe et al. Science. 1999.

Abstract

Strains of mice that show characteristic patterns of behavior are critical for research in neurobehavioral genetics. Possible confounding influences of the laboratory environment were studied in several inbred strains and one null mutant by simultaneous testing in three laboratories on a battery of six behaviors. Apparatus, test protocols, and many environmental variables were rigorously equated. Strains differed markedly in all behaviors, and despite standardization, there were systematic differences in behavior across labs. For some tests, the magnitude of genetic differences depended upon the specific testing lab. Thus, experiments characterizing mutants may yield results that are idiosyncratic to a particular laboratory.

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Comment in

• Behavioral genetics. Fickle mice highlight test problems.
  Enserink M. Enserink M. Science. 1999 Jun 4;284(5420):1599-600. doi: 10.1126/science.284.5420.1599a. Science. 1999. PMID: 10383330 No abstract available.
• Testing the genetics of behavior in mice.
  Picciotto MR, Self DW. Picciotto MR, et al. Science. 1999 Sep 24;285(5436):2067; author reply 2069-70. doi: 10.1126/science.285.5436.2067d. Science. 1999. PMID: 10523199 No abstract available.
• Testing the genetics of behavior in mice.
  Pohorecky LA. Pohorecky LA. Science. 1999 Sep 24;285(5436):2067-8; author reply 2069-70. Science. 1999. PMID: 10523200 No abstract available.
• Testing the genetics of behavior in mice.
  Dawson GR, Flint J, Wilkinson LS. Dawson GR, et al. Science. 1999 Sep 24;285(5436):2068; author reply 2069-70. Science. 1999. PMID: 10523201 No abstract available.
• Testing the genetics of behavior in mice.
  Hen R. Hen R. Science. 1999 Sep 24;285(5436):2068-9; author reply 2069-70. Science. 1999. PMID: 10523202 No abstract available.
• Testing the genetics of behavior in mice.
  Tordoff MG, Bachmanov AA, Friedman MI, Beauchamp GK. Tordoff MG, et al. Science. 1999 Sep 24;285(5436):2069; author reply 2069-70. Science. 1999. PMID: 10523203 No abstract available.

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