A growing family of receptor genes for lysophosphatidic acid (LPA) and other lysophospholipids (LPs) - PubMed (original) (raw)

Review

A growing family of receptor genes for lysophosphatidic acid (LPA) and other lysophospholipids (LPs)

J Chun et al. Cell Biochem Biophys. 1999.

Abstract

A missing component in the experimental analysis of cell signaling by extracellular lysophospholipids such as lysophosphatidic acid (LPA) or sphingosine-1-phosphate (S1P) has been cloned receptors. Through studies on the developing brain, the first such receptor gene (referred to as vzg-1) was identified, representing a member of the G-protein coupled receptor (GPCR) super family (1). Here we review the neurobiological approach that led to both its cloning and identification as a receptor for LPA, along with related expression data. Summarized sequence and genomic structure analyses indicate that this first, functionally identified receptor is encoded by a member of a growing gene family that divides into at least two subgroups: genes most homologous to the high-affinity LPA receptor encoded by vzg-1, and those more homologous to an orphan receptor gene edg-1 that has recently been identified as a S1P receptor. A provisional nomenclature is proposed, based on published functional ligand actions, amino acid composition and genomic structure whereby the receptors encoded by these genes are referred to as lysophospholipid (LP) receptors, with subgroups distinguished by letter and number subscripts (e.g., LPA1 for Vzg-1, and LPB1 for Edg-1). Presented expression data support the recently published work indicating that members of the LPB1 subgroup are receptors for the structurally-related molecule, S1P. The availability of cloned LP receptors will enhance the analysis of the many documented LP effects, while their prominent expression in the nervous system indicates significant but as yet unknown roles in development, normal function, and neuropathology.

PubMed Disclaimer

Cited by

CB1 and LPA1 Receptors Relationship in the Mouse Central Nervous System.
González de San Román E, Manuel I, Ledent C, Chun J, Rodríguez de Fonseca F, Estivill-Torrús G, Santín LJ, Rodríguez Puertas R. González de San Román E, et al. Front Mol Neurosci. 2019 Sep 19;12:223. doi: 10.3389/fnmol.2019.00223. eCollection 2019. Front Mol Neurosci. 2019. PMID: 31607860 Free PMC article.
Role of the G-protein-coupled receptor GPR12 as high-affinity receptor for sphingosylphosphorylcholine and its expression and function in brain development.
Ignatov A, Lintzel J, Hermans-Borgmeyer I, Kreienkamp HJ, Joost P, Thomsen S, Methner A, Schaller HC. Ignatov A, et al. J Neurosci. 2003 Feb 1;23(3):907-14. doi: 10.1523/JNEUROSCI.23-03-00907.2003. J Neurosci. 2003. PMID: 12574419 Free PMC article.
Advancements in understanding the role of lysophospholipids and their receptors in lung disorders including bronchopulmonary dysplasia.
Sudhadevi T, Ha AW, Ebenezer DL, Fu P, Putherickal V, Natarajan V, Harijith A. Sudhadevi T, et al. Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Jul;1865(7):158685. doi: 10.1016/j.bbalip.2020.158685. Epub 2020 Mar 10. Biochim Biophys Acta Mol Cell Biol Lipids. 2020. PMID: 32169655 Free PMC article. Review.
Schwann cell survival mediated by the signaling phospholipid lysophosphatidic acid.
Weiner JA, Chun J. Weiner JA, et al. Proc Natl Acad Sci U S A. 1999 Apr 27;96(9):5233-8. doi: 10.1073/pnas.96.9.5233. Proc Natl Acad Sci U S A. 1999. PMID: 10220449 Free PMC article.
Neuron-astroglial interactions in cell-fate commitment and maturation in the central nervous system.
Stipursky J, Spohr TC, Sousa VO, Gomes FC. Stipursky J, et al. Neurochem Res. 2012 Nov;37(11):2402-18. doi: 10.1007/s11064-012-0798-x. Epub 2012 May 22. Neurochem Res. 2012. PMID: 22614925 Review.

A growing family of receptor genes for lysophosphatidic acid (LPA) and other lysophospholipids (LPs) - PubMed (original) (raw)