RIP3, a novel apoptosis-inducing kinase - PubMed (original) (raw)

Comparative Study

. 1999 Jun 11;274(24):16871-5.

doi: 10.1074/jbc.274.24.16871.

Affiliations

• PMID: 10358032
• DOI: 10.1074/jbc.274.24.16871

Free article

Comparative Study

RIP3, a novel apoptosis-inducing kinase

X Sun et al. J Biol Chem. 1999.

Free article

Abstract

RIP3 is a novel gene product containing a N-terminal kinase domain that shares extensive homology with the corresponding domain in RIP (receptor-interacting protein) and RIP2. Unlike RIP, which has a C-terminal death domain, and RIP2, which has a C-terminal caspase activation and recruitment domain, RIP3 has a unique C terminus. RIP3 binds RIP through its unique C-terminal segment and by virtue of this interaction is recruited to the tumor necrosis factor (TNF) receptor-1 signaling complex. Previous studies have shown that RIP mediates TNF-induced activation of the anti-apoptotic NF-kappaB pathway. RIP3, however, attenuates both RIP and TNF receptor-1-induced NF-kappaB activation. Overexpression studies revealed RIP3 to be a potent inducer of apoptosis, capable of selectively binding to large prodomain initiator caspases.

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