Overexpression of rck/p54, a DEAD box protein, in human colorectal tumours - PubMed (original) (raw)

. 1999 May;80(5-6):914-7.

doi: 10.1038/sj.bjc.6690441.

H Morikawa, I Hirata, M Shiozaki, A Matsumoto, K Maemura, T Nishikawa, M Niki, N Tanigawa, M Ikegami, K Katsu, Y Akao

Affiliations

• PMID: 10360675
• PMCID: PMC2362290
• DOI: 10.1038/sj.bjc.6690441

Free PMC article

Overexpression of rck/p54, a DEAD box protein, in human colorectal tumours

Y Nakagawa et al. Br J Cancer. 1999 May.

Free PMC article

Abstract

The RCK gene is a target of the t(11;14)(q23;q32) chromosomal translocation observed in human B-cell lymphoma, and the overexpression of its protein (rck/p54) by the translocation was shown to cause malignant transformation. The rck/p54 protein belongs to the DEAD box protein/RNA helicase family, which has a variety of functions such as translation initiation, pre-mRNA splicing and ribosome assembly. The expression of rck p54 in colorectal adenocarcinoma cells was examined by immunohistochemistry and Western blot analysis. The rck/p54 protein was found to be overexpressed in tumour tissues resected from 13 (50%) out of 26 cases of colorectal adenocarcinomas and two out of two (100%) cases of colonic severe dysplastic adenomas. In view of activities of rck/p54 determined in other tissue types, we suggest that rck/p54 may contribute to the cell proliferation and carcinogenesis at the translational level in the development of colorectal tumours.

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