Expression of matrix metalloproteinase-1, -2 and -3 in squamous cell carcinoma and actinic keratosis - PubMed (original) (raw)

Expression of matrix metalloproteinase-1, -2 and -3 in squamous cell carcinoma and actinic keratosis

R Tsukifuji et al. Br J Cancer. 1999 Jun.

Free PMC article

Abstract

Matrix metalloproteinase (MMP) plays an important role in extracellular matrix degradation associated with cancer invasion. An expression of MMP-1 (interstitial collagenase), MMP-2 (72-kDa type IV collagenase) and MMP-3 (stromelysin-1) was investigated in squamous cell carcinoma (SCC) and its precancerous condition, actinic keratosis (AK), using in situ hybridization techniques. MMP-1 mRNA was detected in tumour cells and/or in stromal cells in all cases of SCC, four of six AKs adjacent to SCC and four of 16 AKs. MMP-2 and MMP-3 mRNAs were detected in SCC but not in AK. The expression of MMP-3 correlated to that of MMP-1 (P = 0.03) localized at the tumour mass and stroma of the invasive area, while MMP-2 mRNA was detected widely throughout the stroma independent of MMP-1 expression. Our results indicated that the expression of MMP-1, -2 and -3 showed different localization patterns, suggesting a unique role of each MMP in tumour progression. Moreover, MMP-1 expression could be an early event in the development of SCC, and AK demonstrating MMP-1 mRNA, might be in a more advanced dysplastic state, progressing to SCC.

PubMed Disclaimer

Similar articles

Cited by

References

    1. J Cell Biochem. 1993 Dec;53(4):288-95 - PubMed
    1. Int J Cancer. 1993 Aug 19;55(1):10-8 - PubMed
    1. Int J Cancer. 1994 Jul 1;58(1):50-6 - PubMed
    1. Nature. 1994 Jul 7;370(6484):61-5 - PubMed
    1. Mol Carcinog. 1994 Sep;11(1):29-33 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources