p38 mitogen-activated protein kinase activation is required for fibroblast growth factor-2-stimulated cell proliferation but not differentiation - PubMed (original) (raw)
Comparative Study
. 1999 Jun 18;274(25):17491-8.
doi: 10.1074/jbc.274.25.17491.
Affiliations
- PMID: 10364180
- DOI: 10.1074/jbc.274.25.17491
Free article
Comparative Study
p38 mitogen-activated protein kinase activation is required for fibroblast growth factor-2-stimulated cell proliferation but not differentiation
P Maher. J Biol Chem. 1999.
Free article
Abstract
Basic fibroblast growth factor (FGF-2) is a member of a family of polypeptides that have roles in a wide range of biological processes. To determine why different cell types show distinct responses to treatment with FGF-2, the array of FGF receptors present on the surface of a cell which differentiates in response to FGF-2 (PC12 cells) was compared with that present on the surface of a cell that proliferates in response to FGF-2 (Swiss 3T3 fibroblasts). Both cell types express exclusively FGFR1, suggesting that there are cell type-specific FGFR1 signaling pathways. Since mitogen-activated protein kinases function as mediators of cellular responses to a variety of stimuli, the roles of these proteins in FGF-mediated responses were examined. FGF-2 activates extracellular signal-regulated kinases with similar kinetics in both fibroblasts and PC12 cells, and a specific inhibitor of extracellular signal-regulated kinase activation blocks differentiation but has little effect on proliferation. In contrast, while p38 mitogen-activated protein kinase is activated weakly and transiently in PC12 cells treated with FGF-2, a much stronger and sustained activation of this kinase is seen in FGF-2-treated fibroblasts. Furthermore, specific inhibitors of this kinase block proliferation but have no effect on differentiation. This effect on proliferation is specific for FGF-2 since the same concentrations of inhibitors have little or no effect on proliferation induced by serum.
Similar articles
- Fibroblast growth factor receptor signaling activates the human interstitial collagenase promoter via the bipartite Ets-AP1 element.
Newberry EP, Willis D, Latifi T, Boudreaux JM, Towler DA. Newberry EP, et al. Mol Endocrinol. 1997 Jul;11(8):1129-44. doi: 10.1210/mend.11.8.9958. Mol Endocrinol. 1997. PMID: 9212060 - Differential activation of mitogen-activated protein kinase in response to basic fibroblast growth factor in skeletal muscle cells.
Campbell JS, Wenderoth MP, Hauschka SD, Krebs EG. Campbell JS, et al. Proc Natl Acad Sci U S A. 1995 Jan 31;92(3):870-4. doi: 10.1073/pnas.92.3.870. Proc Natl Acad Sci U S A. 1995. PMID: 7846069 Free PMC article. - Growth factor regulation of cell growth and proliferation in the nervous system. A new intracrine nuclear mechanism.
Stachowiak MK, Moffett J, Maher P, Tucholski J, Stachowiak EK. Stachowiak MK, et al. Mol Neurobiol. 1997 Dec;15(3):257-83. doi: 10.1007/BF02740663. Mol Neurobiol. 1997. PMID: 9457702 Review. - The role of fibroblast growth factor 8 in cartilage development and disease.
Chen H, Cui Y, Zhang D, Xie J, Zhou X. Chen H, et al. J Cell Mol Med. 2022 Feb;26(4):990-999. doi: 10.1111/jcmm.17174. Epub 2022 Jan 9. J Cell Mol Med. 2022. PMID: 35001536 Free PMC article. Review.
Cited by
- Scaffolding proteins DLG1 and CASK cooperate to maintain the nephron progenitor population during kidney development.
Ahn SY, Kim Y, Kim ST, Swat W, Miner JH. Ahn SY, et al. J Am Soc Nephrol. 2013 Jun;24(7):1127-38. doi: 10.1681/ASN.2012111074. Epub 2013 May 9. J Am Soc Nephrol. 2013. PMID: 23661808 Free PMC article. - Contribution of the p38MAPK signalling pathway to proliferation in human cultured airway smooth muscle cells is mitogen-specific.
Fernandes DJ, Ravenhall CE, Harris T, Tran T, Vlahos R, Stewart AG. Fernandes DJ, et al. Br J Pharmacol. 2004 Aug;142(7):1182-90. doi: 10.1038/sj.bjp.0705809. Epub 2004 Jul 12. Br J Pharmacol. 2004. PMID: 15249425 Free PMC article. - Differential p38-dependent signalling in response to cellular stress and mitogenic stimulation in fibroblasts.
Faust D, Schmitt C, Oesch F, Oesch-Bartlomowicz B, Schreck I, Weiss C, Dietrich C. Faust D, et al. Cell Commun Signal. 2012 Mar 9;10:6. doi: 10.1186/1478-811X-10-6. Cell Commun Signal. 2012. PMID: 22404972 Free PMC article. - Divergence in signaling pathways involved in promotion of cell viability mediated by bFGF, NGF, and EGF in PC12 cells.
Kawamata T, Yamaguchi T, Shin-ya K, Hori T. Kawamata T, et al. Neurochem Res. 2003 Aug;28(8):1221-5. doi: 10.1023/a:1024284529945. Neurochem Res. 2003. PMID: 12834262 - FGF2, an Immunomodulatory Factor in Asthma and Chronic Obstructive Pulmonary Disease (COPD).
Tan Y, Qiao Y, Chen Z, Liu J, Guo Y, Tran T, Tan KS, Wang DY, Yan Y. Tan Y, et al. Front Cell Dev Biol. 2020 Apr 2;8:223. doi: 10.3389/fcell.2020.00223. eCollection 2020. Front Cell Dev Biol. 2020. PMID: 32300593 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous