Dosage compensation proteins targeted to X chromosomes by a determinant of hermaphrodite fate - PubMed (original) (raw)
Comment
Dosage compensation proteins targeted to X chromosomes by a determinant of hermaphrodite fate
H E Dawes et al. Science. 1999.
Abstract
In many organisms, master control genes coordinately regulate sex-specific aspects of development. SDC-2 was shown to induce hermaphrodite sexual differentiation and activate X chromosome dosage compensation in Caenorhabditis elegans. To control these distinct processes, SDC-2 acts as a strong gene-specific repressor and a weaker chromosome-wide repressor. To initiate hermaphrodite development, SDC-2 associates with the promoter of the male sex-determining gene her-1 to repress its transcription. To activate dosage compensation, SDC-2 triggers assembly of a specialized protein complex exclusively on hermaphrodite X chromosomes to reduce gene expression by half. SDC-2 can localize to X chromosomes without other components of the dosage compensation complex, suggesting that SDC-2 targets dosage compensation machinery to X chromosomes.
Comment on
- Sex and repression.
Kuroda MI, Kelley RL. Kuroda MI, et al. Science. 1999 Jun 11;284(5421):1787-8. doi: 10.1126/science.284.5421.1787. Science. 1999. PMID: 10391797 No abstract available.
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